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Chromodomain Helicase DNA Binding Protein 5 (CHD5)

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ATP-dependent helicase CHD5

Chromodomain Helicase DNA Binding Protein 5 (CHD5)
CCC C211
HGNC 16816
MGI 3036258
PubMed 22186629
RGD 1582725
UniProt Q8TDI0
Wiki CHD5
Changes in gene expression are associated with changes in chromatin structure, which can result from modification of histones by acetylation and methylation. In addition, SWI/SNF proteins can effect chromatin structure and gene expression by causing ATP-dependent disruption of the nucleosome and by enhancing binding of transcription factors.
CHD5 belongs to a group of SWI/SNF proteins called CHD proteins, which contain a SWI/SNF-like helicase/ATPase domain, as well as a DNA-binding domain and a chromodomain that directly modifies chromatin structure. CHD5 May play a role in the development of the nervous system and the pathogenesis of neural tumors. Preferentially expressed in total brain, fetal brain, and cerebellum. It is also moderately expressed in the adrenal gland.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC211Hu01 Recombinant Chromodomain Helicase DNA Binding Protein 5 (CHD5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC211Hu01 Polyclonal Antibody to Chromodomain Helicase DNA Binding Protein 5 (CHD5) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Chromodomain Helicase DNA Binding Protein 5 (CHD5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Chromodomain Helicase DNA Binding Protein 5 (CHD5) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Chromodomain Helicase DNA Binding Protein 5 (CHD5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Chromodomain Helicase DNA Binding Protein 5 (CHD5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Chromodomain Helicase DNA Binding Protein 5 (CHD5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Chromodomain Helicase DNA Binding Protein 5 (CHD5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Chromodomain Helicase DNA Binding Protein 5 (CHD5) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Chromodomain Helicase DNA Binding Protein 5 (CHD5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Chromodomain Helicase DNA Binding Protein 5 (CHD5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Chromodomain Helicase DNA Binding Protein 5 (CHD5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Chromodomain Helicase DNA Binding Protein 5 (CHD5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Chromodomain Helicase DNA Binding Protein 5 (CHD5) ELISA Kit Customized Service Offer
  1. "CHD5, a new member of the chromodomain gene family, is preferentially expressed in the nervous system."Oncogene 22:1002-1011(2003) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  4. "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain."DNA Res. 4:345-349(1997) [PubMed] [Europe PMC] [Abstract]
  5. "CHD5 is a tumor suppressor at human 1p36."Cell 128:459-475(2007) [PubMed] [Europe PMC] [Abstract]
  6. "CHD5, a brain-specific paralog of Mi2 chromatin remodeling enzymes, regulates expression of neuronal genes."PLoS ONE 6:E24515-E24515(2011) [PubMed] [Europe PMC] [Abstract]
  7. "CHD5 is required for neurogenesis and has a dual role in facilitating gene expression and polycomb gene repression."Dev. Cell 26:223-236(2013) [PubMed] [Europe PMC] [Abstract]
  8. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]