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ACVR2A is an activin type 2 receptor. This gene encodes activin A type II receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors.
These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPC117Hu01 | Recombinant Activin A Receptor Type II A (ACVR2A) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAC117Hu01 | Polyclonal Antibody to Activin A Receptor Type II A (ACVR2A) | WB; IHC; ICC; IP. |
| MAC117Hu21 | Monoclonal Antibody to Activin A Receptor Type II A (ACVR2A) | WB,IHC | |
| MAC117Hu22 | Monoclonal Antibody to Activin A Receptor Type II A (ACVR2A) | WB; IHC; ICC; IP. | |
| MAC117Hu24 | Monoclonal Antibody to Activin A Receptor Type II A (ACVR2A) | WB | |
| MAC117Hu27 | Monoclonal Antibody to Activin A Receptor Type II A (ACVR2A) | WB; IHC; ICC; IP. | |
| MAC117Hu23 | Monoclonal Antibody to Activin A Receptor Type II A (ACVR2A) | IHC | |
| MAC117Hu25 | Monoclonal Antibody to Activin A Receptor Type II A (ACVR2A) | WB; IHC; ICC; IP. | |
| Assay Kits | SEC117Hu | ELISA Kit for Activin A Receptor Type II A (ACVR2A) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPC117Mu01 | Recombinant Activin A Receptor Type II A (ACVR2A) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPC117Mu02 | Recombinant Activin A Receptor Type II A (ACVR2A) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAC117Mu01 | Polyclonal Antibody to Activin A Receptor Type II A (ACVR2A) | WB; IHC; ICC; IP. |
| PAC117Mu02 | Polyclonal Antibody to Activin A Receptor Type II A (ACVR2A) | WB; IHC; ICC; IP. | |
| LAC117Mu71 | Biotin-Linked Polyclonal Antibody to Activin A Receptor Type II A (ACVR2A) | WB; IHC; ICC. | |
| Assay Kits | n/a | CLIA Kit for Activin A Receptor Type II A (ACVR2A) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Activin A Receptor Type II A (ACVR2A) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Activin A Receptor Type II A (ACVR2A) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Activin A Receptor Type II A (ACVR2A) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Activin A Receptor Type II A (ACVR2A) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Activin A Receptor Type II A (ACVR2A) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Activin A Receptor Type II A (ACVR2A) | ELISA Kit Customized Service Offer |
Organism species: Bos taurus; Bovine (Cattle)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPC117Bo01 | Recombinant Activin A Receptor Type II A (ACVR2A) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPC117Bo02 | Recombinant Activin A Receptor Type II A (ACVR2A) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAC117Bo01 | Polyclonal Antibody to Activin A Receptor Type II A (ACVR2A) | WB; IHC; ICC; IP. |
| PAC117Bo02 | Polyclonal Antibody to Activin A Receptor Type II A (ACVR2A) | WB; IHC; ICC; IP. | |
| Assay Kits | n/a | CLIA Kit for Activin A Receptor Type II A (ACVR2A) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Activin A Receptor Type II A (ACVR2A) | ELISA Kit Customized Service Offer |
- "Cloning of the human activin receptor cDNA reveals high evolutionary conservation."Biochim. Biophys. Acta 1130:105-108(1992) [PubMed] [Europe PMC] [Abstract]
- "Molecular cloning and binding properties of the human type II activin receptor."Biochem. Biophys. Res. Commun. 184:310-316(1992) [PubMed] [Europe PMC] [Abstract]
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Crystal structure of activin receptor type-IIa (ACVR2A) kinase domain in complex with dorsomorphin."Submitted (FEB-2011) to the PDB data bank
- "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
- "Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma." Nature 469:539-542(2011) [PubMed] [Europe PMC] [Abstract]