≡

Activin A Receptor Type I B (ACVR1B)

[Edit]

ACVR1-B; ACTRIB; ACVRLK4; ALK4; SKR2; Activin receptor-like kinase 4; Serine/threonine-protein kinase receptor R2

Activin A Receptor Type I B (ACVR1B)
CCC C115
HGNC 172
MGI 1338944
PubMed 11248065
RGD 735207
UniProt P36896
Wiki ACVR1B

ACVR1B acts as a transducer of Activin or activin like ligands signals. Activin binds to either ACVR2A or ACVR2B and then forms a complex with ACVR1B. These go on to recruit the R-SMADs SMAD2 or SMAD3.ACVR1B also transduces signals of nodal, GDF-1, and Vg1; however, unlike activin, they require other coreceptor molecules such as the protein Cripto.Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I and two type II receptors. several truncated ACVR1B receptor isoforms are exclusively expressed in human pituitary tumors, and that the majority of such tumors did not exhibit activin-induced growth arrest in culture.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC115Hu01 Recombinant Activin A Receptor Type I B (ACVR1B) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC115Hu01 Polyclonal Antibody to Activin A Receptor Type I B (ACVR1B) WB; IHC; ICC; IP.
LAC115Hu71 Biotin-Linked Polyclonal Antibody to Activin A Receptor Type I B (ACVR1B) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Activin A Receptor Type I B (ACVR1B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Activin A Receptor Type I B (ACVR1B) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC115Mu01 Recombinant Activin A Receptor Type I B (ACVR1B) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC115Mu01 Polyclonal Antibody to Activin A Receptor Type I B (ACVR1B) WB; IHC; ICC; IP.
LAC115Mu71 Biotin-Linked Polyclonal Antibody to Activin A Receptor Type I B (ACVR1B) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Activin A Receptor Type I B (ACVR1B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Activin A Receptor Type I B (ACVR1B) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Activin A Receptor Type I B (ACVR1B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Activin A Receptor Type I B (ACVR1B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Activin A Receptor Type I B (ACVR1B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Activin A Receptor Type I B (ACVR1B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Activin A Receptor Type I B (ACVR1B) ELISA Kit Customized Service Offer
  1. "Activin receptor-like kinases: a novel subclass of cell-surface receptors with predicted serine/threonine kinase activity."Oncogene 8:2879-2887(1993) [PubMed] [Europe PMC] [Abstract]
  2. "Type I receptors specify growth-inhibitory and transcriptional responses to transforming growth factor beta and activin."Mol. Cell. Biol. 14:3810-3821(1994) [PubMed] [Europe PMC] [Abstract]
  3. "Genomic structure and cloned cDNAs predict that four variants in the kinase domain of serine/threonine kinase receptors arise by alternative splicing and poly(A) addition."Proc. Natl. Acad. Sci. U.S.A. 91:7957-7961(1994) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Activation of signalling by the activin receptor complex."Mol. Cell. Biol. 16:1066-1073(1996) [PubMed] [Europe PMC] [Abstract]
  8. "Activin and inhibin have antagonistic effects on ligand-dependent heteromerization of the type I and type II activin receptors and human erythroid differentiation."Mol. Cell. Biol. 17:1682-1691(1997) [PubMed] [Europe PMC] [Abstract]
  9. "Roles of pathway-specific and inhibitory Smads in activin receptor signaling."Mol. Endocrinol. 13:15-23(1999) [PubMed] [Europe PMC] [Abstract]
  10. "Modulation of activin signal transduction by inhibin B and inhibin-binding protein (INhBP)."Mol. Endocrinol. 15:668-679(2001) [PubMed] [Europe PMC] [Abstract]
  11. "Phosphorylation regulation of the interaction between Smad7 and activin type I receptor."FEBS Lett. 519:93-98(2002) [PubMed] [Europe PMC] [Abstract]
  12. "Overexpression of wild-type activin receptor alk4-1 restores activin antiproliferative effects in human pituitary tumor cells."J. Clin. Endocrinol. Metab. 87:4741-4746(2002) [PubMed] [Europe PMC] [Abstract]
  13. "Cripto-1 activates nodal- and ALK4-dependent and -independent signaling pathways in mammary epithelial Cells."Mol. Cell. Biol. 22:2586-2597(2002) [PubMed] [Europe PMC] [Abstract]
  14. "Identification of the phosphotyrosine proteome from thrombin activated platelets."Proteomics 2:642-648(2002) [PubMed] [Europe PMC] [Abstract]
  15. "Activin signaling through type IB activin receptor stimulates aromatase activity in the ovarian granulosa cell-like human granulosa (KGN) cells."Endocrinology 144:1603-1611(2003) [PubMed] [Europe PMC] [Abstract]
  16. "Identification of a functional binding site for activin on the type I receptor ALK4."J. Biol. Chem. 278:21129-21135(2003) [PubMed] [Europe PMC] [Abstract]
  17. "FKBP12 functions as an adaptor of the Smad7-Smurf1 complex on activin type I receptor."J. Mol. Endocrinol. 36:569-579(2006) [PubMed] [Europe PMC] [Abstract]
  18. "Ttrap is an essential modulator of Smad3-dependent Nodal signaling during zebrafish gastrulation and left-right axis determination."Development 134:4381-4393(2007) [PubMed] [Europe PMC] [Abstract]
  19. "Activin A induces neuronal differentiation and survival via ALK4 in a SMAD-independent manner in a subpopulation of human neuroblastomas."Biochem. Biophys. Res. Commun. 394:639-645(2010) [PubMed] [Europe PMC] [Abstract]
  20. "Development and validation of a method for profiling post-translational modification activities using protein microarrays."PLoS ONE 5:E11332-E11332(2010) [PubMed] [Europe PMC] [Abstract]
  21. "Activation of the activin A-ALK-Smad pathway in systemic sclerosis."J. Autoimmun. 36:181-188(2011) [PubMed] [Europe PMC] [Abstract]
  22. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]