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Phospholipase B (PLB)

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PLB; PL-B1; PLB1; PLB/LIP; Phospholipase B1, membrane-associated; Phospholipase B/lipase; Lysophospholipase; Phospholipase A2

Phospholipase B (PLB)
CCC C048
HGNC 30041
MGI 1922406
PubMed 15888468
UniProt Q6P1J6
Wiki PLB

By Western blot analysis using an antibody against guinea pig phospholipase B (PLB), Maury et al. (2002) detected a 97-kD polypeptide in the soluble and membrane fractions of human epidermis that was enriched in the soluble fraction. Consistent with these results, they found that PLB activity was greatest in the soluble fraction.

Trypsin had no effect on the molecular mass or enzymatic activity, suggesting that the protein they detected was already in an active form.

Immunolocalization experiments revealed that PLB is expressed in the entire human epidermis with an accumulation in the dermoepidermis junction. In situ hybridization also indicated expression in the entire epidermis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC048Hu01 Recombinant Phospholipase B (PLB) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC048Hu01 Polyclonal Antibody to Phospholipase B (PLB) WB,IHC
MAC048Hu22 Monoclonal Antibody to Phospholipase B (PLB) WB; IHC; ICC; IP.
MAC048Hu21 Monoclonal Antibody to Phospholipase B (PLB) WB; IHC; ICC; IP.
Assay Kits SEC048Hu ELISA Kit for Phospholipase B (PLB) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phospholipase B (PLB) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phospholipase B (PLB) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phospholipase B (PLB) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phospholipase B (PLB) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phospholipase B (PLB) ELISA Kit Customized Service Offer
  1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Human epidermis is a novel site of phospholipase B expression."Biochem. Biophys. Res. Commun. 295:362-369(2002) [PubMed] [Europe PMC] [Abstract]