Interleukin 22 (IL22)

[Edit]

ILTIF; Zcyto18; IL-TIF; IL-D110; TIFa; TIFIL-23; IL-22; Cytokine Zcyto18; IL-10-Related T-Cell-Derived Inducible Factor

Interleukin 22 (IL22)

IL-22, a class of potent mediators of cellular inflammatory responses. It shares us of IL-10R2 in cell signaling with other members of this family, IL-10, IL-26, IL-28, IL-29. IL-22 is produced by activated DC and T cells and initiates innate immune responses against bacterial pathogens especially in epithelial cells such as respiratory and gut epithelial cells.

IL-22 along with IL-17 is rapidly produced by splenic LTi-like cells  and can be also produced by Th17 cells and likely plays a role in the coordinated response of both adaptive and innate immune systems.IL-22 biological activity is initiated by binding to a cell-surface complex composed of IL-22R1 and IL-10R2 receptor chains and further regulated by interactions with a soluble binding protein, IL-22BP, which shares sequence similarity with an extracellular region of IL-22R1.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC032Hu01 Recombinant Interleukin 22 (IL22) Positive Control; Immunogen; SDS-PAGE; WB.
EPC032Hu61 Eukaryotic Interleukin 22 (IL22) Positive Control; Immunogen; SDS-PAGE; WB.
APC032Hu61 Active Interleukin 22 (IL22) Cell culture; Activity Assays.
APC032Hu01 Active Interleukin 22 (IL22) Cell culture; Activity Assays.
Antibodies PAC032Hu01 Polyclonal Antibody to Interleukin 22 (IL22) WB; IHC; ICC; IP.
MAC032Hu22 Monoclonal Antibody to Interleukin 22 (IL22) WB
MAC032Hu21 Monoclonal Antibody to Interleukin 22 (IL22) WB; IHC; ICC; IP.
MAC032Hu23 Monoclonal Antibody to Interleukin 22 (IL22) WB; IHC; ICC; IP.
Assay Kits SEC032Hu ELISA Kit for Interleukin 22 (IL22) Enzyme-linked immunosorbent assay for Antigen Detection.
SCC032Hu CLIA Kit for Interleukin 22 (IL22) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC032Mu01 Recombinant Interleukin 22 (IL22) Positive Control; Immunogen; SDS-PAGE; WB.
RPC032Mu02 Recombinant Interleukin 22 (IL22) Positive Control; Immunogen; SDS-PAGE; WB.
APC032Mu61 Active Interleukin 22 (IL22) Cell culture; Activity Assays.
Antibodies PAC032Mu01 Polyclonal Antibody to Interleukin 22 (IL22) WB; IHC; ICC; IP.
PAC032Mu02 Polyclonal Antibody to Interleukin 22 (IL22) WB; IHC; ICC; IP.
Assay Kits SEC032Mu ELISA Kit for Interleukin 22 (IL22) Enzyme-linked immunosorbent assay for Antigen Detection.
SCC032Mu CLIA Kit for Interleukin 22 (IL22) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC032Ra01 Recombinant Interleukin 22 (IL22) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Interleukin 22 (IL22) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Interleukin 22 (IL22) Polyclonal Antibody Customized Service Offer
Assay Kits SEC032Ra ELISA Kit for Interleukin 22 (IL22) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC032Bo01 Recombinant Interleukin 22 (IL22) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC032Bo01 Polyclonal Antibody to Interleukin 22 (IL22) WB; IHC; ICC; IP.
MAC032Bo21 Monoclonal Antibody to Interleukin 22 (IL22) WB; IHC; ICC; IP.
Assay Kits SEC032Bo ELISA Kit for Interleukin 22 (IL22) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Human interleukin-10-related T cell-derived inducible factor: molecular cloning and functional characterization as an hepatocyte-stimulating factor."Proc. Natl. Acad. Sci. U.S.A. 97:10144-10149(2000) [PubMed] [Europe PMC] [Abstract]
  2. "IL-TIF/IL-22: genomic organization and mapping of the human and mouse genes."Genes Immun. 1:488-494(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R."J. Biol. Chem. 275:31335-31339(2000) [PubMed] [Europe PMC] [Abstract]
  4. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Crystallization and synchrotron X-ray diffraction studies of human interleukin-22."Acta Crystallogr. D 58:529-530(2002) [PubMed] [Europe PMC] [Abstract]
  8. "Structure of insect-cell-derived IL-22."Acta Crystallogr. D 61:942-950(2005) [PubMed] [Europe PMC] [Abstract]
  9. "Structure of IL-22 bound to its high-affinity IL-22R1 chain."Structure 16:1333-1344(2008) [PubMed] [Europe PMC] [Abstract]