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Apolipoprotein C2 (APOC2)

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APC2; Apo-C2; ProapoC-II; Apolipoprotein C-II; Proapolipoprotein C-II

Apolipoprotein C2 (APOC2)
CCC B996
HGNC 609
MGI 88054
PubMed 2892779
RGD 2135
UniProt P02655
Wiki APOC2

Apolipoprotein C2 is secreted in plasma where it is a component of very low density lipoprotein. This protein activates the enzyme lipoprotein lipase, which hydrolyzes triglycerides and thus provides free fatty acids for cells. Mutations in this gene cause hyperlipoproteinemia type IB, characterized by hypertriglyceridemia, xanthomas, and increased risk of pancreatitis and early atherosclerosis. Apolipoprotein C-II (apoC-II) is a necessary cofactor for the activation of lipoprotein lipase (LPL), the enzyme that hydrolyzes triglycerides in plasma and transfers the fatty acids to tissues.The APOC2 cDNA sequence encodes a deduced 79-amino acid protein. Using synthetic oligonucleotides as probes, Sakaguchi et al. (1984) isolated APOC2 from a human cDNA library.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB996Hu01 Recombinant Apolipoprotein C2 (APOC2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB996Hu01 Polyclonal Antibody to Apolipoprotein C2 (APOC2) WB; IHC; ICC; IP.
MAB996Hu22 Monoclonal Antibody to Apolipoprotein C2 (APOC2) WB; IHC; ICC; IP.
Assay Kits SEB996Hu ELISA Kit for Apolipoprotein C2 (APOC2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB996Mu01 Recombinant Apolipoprotein C2 (APOC2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB996Mu01 Polyclonal Antibody to Apolipoprotein C2 (APOC2) WB; IHC; ICC; IP.
LAB996Mu71 Biotin-Linked Polyclonal Antibody to Apolipoprotein C2 (APOC2) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Apolipoprotein C2 (APOC2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Apolipoprotein C2 (APOC2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB996Ra01 Recombinant Apolipoprotein C2 (APOC2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB996Ra01 Polyclonal Antibody to Apolipoprotein C2 (APOC2) WB; IHC; ICC; IP.
MAB996Ra21 Monoclonal Antibody to Apolipoprotein C2 (APOC2) WB; IHC; ICC; IP.
Assay Kits SEB996Ra ELISA Kit for Apolipoprotein C2 (APOC2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Cavia (Guinea pig )

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB996Gu01 Recombinant Apolipoprotein C2 (APOC2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB996Gu01 Polyclonal Antibody to Apolipoprotein C2 (APOC2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Apolipoprotein C2 (APOC2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Apolipoprotein C2 (APOC2) ELISA Kit Customized Service Offer

Organism species: Equus caballus; Equine (Horse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB996Eq01 Recombinant Apolipoprotein C2 (APOC2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB996Eq01 Polyclonal Antibody to Apolipoprotein C2 (APOC2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Apolipoprotein C2 (APOC2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Apolipoprotein C2 (APOC2) ELISA Kit Customized Service Offer
  1. "The human preproapolipoprotein C-II gene. Complete nucleic acid sequence and genomic organization."FEBS Lett. 213:221-226(1987) [PubMed] [Europe PMC] [Abstract]
  2. "Human apolipoprotein C-II: complete nucleic acid sequence of preapolipoprotein C-II."Proc. Natl. Acad. Sci. U.S.A. 81:6354-6357(1984) [PubMed] [Europe PMC] [Abstract]
  3. "Human apolipoproteins AI, AII, CII and CIII. cDNA sequences and mRNA abundance."Nucleic Acids Res. 12:3917-3932(1984) [PubMed] [Europe PMC] [Abstract]
  4. "The human apolipoprotein C-II gene sequence contains a novel chromosome 19-specific minisatellite in its third intron."J. Biol. Chem. 262:4787-4793(1987) [PubMed] [Europe PMC] [Abstract]
  5. "The structure of the human apolipoprotein C-II gene. Electron microscopic analysis of RNA:DNA hybrids, complete nucleotide sequence, and identification of 5' homologous sequences among apolipoprotein genes."J. Biol. Chem. 260:15211-15221(1985) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The isolation and characterization of cDNA clones for human apolipoprotein CII."J. Biol. Chem. 259:4401-4404(1984) [PubMed] [Europe PMC] [Abstract]
  8. "Isolation of cDNA and genomic clones for apolipoprotein C-II."Methods Enzymol. 128:788-800(1986) [PubMed] [Europe PMC] [Abstract]
  9. "Amino acid sequence of human plasma apolipoprotein C-II from normal and hyperlipoproteinemic subjects."J. Biol. Chem. 259:318-322(1984) [PubMed] [Europe PMC] [Abstract]
  10. "Primary structure of very low density apolipoprotein C-II of human plasma."Proc. Natl. Acad. Sci. U.S.A. 74:1942-1945(1977) [PubMed] [Europe PMC] [Abstract]
  11. "Human preproapolipoprotein C-II. Analysis of major plasma isoforms."J. Biol. Chem. 261:9591-9594(1986) [PubMed] [Europe PMC] [Abstract]
  12. "Expression of the apolipoprotein C-II gene during myelomonocytic differentiation of human leukemic cells."J. Leukoc. Biol. 69:645-650(2001) [PubMed] [Europe PMC] [Abstract]
  13. "Primary structure of the bovine analogues to human apolipoproteins CII and CIII. Studies on isoforms and evidence for proteolytic processing."Eur. J. Biochem. 192:515-521(1990) [PubMed] [Europe PMC] [Abstract]
  14. "A review of the role of apolipoprotein C-II in lipoprotein metabolism and cardiovascular disease."Metabolism 61:906-921(2012) [PubMed] [Europe PMC] [Abstract]
  15. "LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins."J. Proteome Res. 12:573-584(2013) [PubMed] [Europe PMC] [Abstract]
  16. "Sequence specific 1H-NMR assignments and secondary structure of a carboxy-terminal functional fragment of apolipoprotein CII."Eur. J. Biochem. 205:223-231(1992) [PubMed] [Europe PMC] [Abstract]
  17. "A refined three-dimensional solution structure of a carboxy terminal fragment of apolipoprotein CII."Eur. Biophys. J. 22:351-357(1993) [PubMed] [Europe PMC] [Abstract]
  18. "A variant primary structure of apolipoprotein C-II in individuals of African descent."J. Clin. Invest. 77:595-601(1986) [PubMed] [Europe PMC] [Abstract]
  19. "Molecular cloning and characteristics of a new apolipoprotein C-II mutant identified in three unrelated individuals with hypercholesterolemia and hypertriglyceridemia."Hum. Mol. Genet. 2:69-74(1993) [PubMed] [Europe PMC] [Abstract]
  20. "An apolipoprotein CII mutation, CII Lys-19-->Thr identified in patients with hyperlipidemia."Dis. Markers 9:73-80(1991) [PubMed] [Europe PMC] [Abstract]
  21. "The apolipoprotein C-II variant apoC-II Lys-19-->Thr is not associated with dyslipidemia in an affected kindred."Clin. Genet. 45:292-297(1994) [PubMed] [Europe PMC] [Abstract]
  22. "A missense mutation (Trp 26-->Arg) in exon 3 of the apolipoprotein CII gene in a patient with apolipoprotein CII deficiency (apo CII-Wakayama)."Biochem. Biophys. Res. Commun. 193:1174-1183(1993) [PubMed] [Europe PMC] [Abstract]
  23. "Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis."Nat. Genet. 22:239-247(1999) [PubMed] [Europe PMC] [Abstract]