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Endothelin Receptor A (ETRA)

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EDNRA; ETA; ETR-A; Endothelin A receptor; Endothelin-1 receptor

Endothelin Receptor A (ETRA)
CCC B981
HGNC 3179
MGI 105923
PubMed 21801590
RGD 2535
UniProt P25101
Wiki ETRA

, is a human G protein-coupled receptor.The endothelin receptor with highest affinity for ET1 has been called ETA. Cyr et al. (1991) isolated a cDNA clone of a human endothelin receptor from a placental cDNA library. The deduced amino acid sequence was 94% identical to the bovine endothelin ETA receptor and was judged to represent the human homolog.

Hosoda et al. (1992) isolated and characterized the gene for the human endothelin-A receptor. Southern blot analyses demonstrated that it is present in single copy. Northern blot analyses demonstrated a 4.3-kb mRNA in a wide variety of human tissues with the highest level in the aorta and a substantial level in cultured human mesangial cells.

 

 

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Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB981Hu01 Recombinant Endothelin Receptor A (ETRA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB981Hu01 Polyclonal Antibody to Endothelin Receptor A (ETRA) WB; IHC; ICC; IP.
MAB981Hu22 Monoclonal Antibody to Endothelin Receptor A (ETRA) WB; IHC; ICC; IP.
Assay Kits SEB981Hu ELISA Kit for Endothelin Receptor A (ETRA) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Endothelin Receptor A (ETRA) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Endothelin Receptor A (ETRA) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Endothelin Receptor A (ETRA) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Endothelin Receptor A (ETRA) CLIA Kit Customized Service Offer
n/a ELISA Kit for Endothelin Receptor A (ETRA) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Endothelin Receptor A (ETRA) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Endothelin Receptor A (ETRA) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Endothelin Receptor A (ETRA) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Endothelin Receptor A (ETRA) CLIA Kit Customized Service Offer
n/a ELISA Kit for Endothelin Receptor A (ETRA) ELISA Kit Customized Service Offer
  1. "Cloning and characterization of cDNA encoding human A-type endothelin receptor."Biochem. Biophys. Res. Commun. 180:1265-1272(1991) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning and chromosomal localization of a human endothelin ETA receptor."Biochem. Biophys. Res. Commun. 181:184-190(1991) [PubMed] [Europe PMC] [Abstract]
  3. "Cloning and expression of human endothelin-1 receptor cDNA."FEBS Lett. 287:23-26(1991) [PubMed] [Europe PMC] [Abstract]
  4. "Molecular cloning of human endothelin receptors and their expression in vascular endothelial cells and smooth muscle cells."Jpn. Circ. J. 56:1303-1307(1992) [PubMed] [Europe PMC] [Abstract]
  5. "Molecular characterization and regulation of the human endothelin receptors."J. Biol. Chem. 268:3873-3879(1993) [PubMed] [Europe PMC] [Abstract]
  6. "Organization, structure, chromosomal assignment, and expression of the gene encoding the human endothelin-A receptor."J. Biol. Chem. 267:18797-18804(1992) [PubMed] [Europe PMC] [Abstract]
  7. "Cloning and expression of a human endothelin receptor: subtype A."Am. J. Med. Sci. 304:231-238(1992) [PubMed] [Europe PMC] [Abstract]
  8. "Alternative RNA splicing of the human endothelin-A receptor generates multiple transcripts."Biochem. J. 313:795-801(1996) [PubMed] [Europe PMC] [Abstract]
  9. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  11. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  12. "Molecular characterization of the 5'-flanking region of human genomic ETA gene."Biochem. Biophys. Res. Commun. 190:332-339(1993) [PubMed] [Europe PMC] [Abstract]
  13. "Endothelin-1 and ETA receptor expression in vascular smooth muscle cells from human placenta: a new ETA receptor messenger ribonucleic acid is generated by alternative splicing of exon 3."J. Clin. Endocrinol. Metab. 82:3116-3123(1997) [PubMed] [Europe PMC] [Abstract]
  14. "Tip60 and HDAC7 interact with the endothelin receptor a and may be involved in downstream signaling."J. Biol. Chem. 276:16597-16600(2001) [PubMed] [Europe PMC] [Abstract]
  15. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]