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Pigment Epithelium Derived Factor (PEDF)

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SERPINF1; EPC1; PIG35; SDF3; Serpin F1; Cell proliferation-inducing gene 35; Serpin Peptidase Inhibitor,Clade F Member 1(Alpha-2 Antiplasmin); Stromal Cell Derived Factor 3

Pigment Epithelium Derived Factor (PEDF)
CCC B972
HGNC 8824
MGI 108080
PubMed 12957143
RGD 631369
UniProt P36955
Wiki PEDF

The PEDF gene is a member of the serpin gene family. Serpins are a group of serine protease inhibitors, some of which have also been reported to exhibit neurotrophic activity.By the analysis of 3 independent somatic cell hybrid panels, Tombran-Tink et al. (1994) assigned the PEDF gene to chromosome 17. Fluorescence in situ hybridization showed localization at the terminal portion of 17p. PCR analysis of somatic cell hybrids containing specific regions of 17 were subsequently used to sublocalize PEDF to 17pter-p13.1. Greenberg et al. (1997) used linkage analysis to narrow the localization of the PEDF gene to 17p13.3, the same region as that carrying the autosomal dominant retinitis pigmentosa locus (RP13) identified in a South African family.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB972Hu01 Recombinant Pigment Epithelium Derived Factor (PEDF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB972Hu01 Polyclonal Antibody to Pigment Epithelium Derived Factor (PEDF) WB; IHC; ICC; IP.
MAB972Hu22 Monoclonal Antibody to Pigment Epithelium Derived Factor (PEDF) WB; IHC; ICC; IP.
Assay Kits SEB972Hu ELISA Kit for Pigment Epithelium Derived Factor (PEDF) Enzyme-linked immunosorbent assay for Antigen Detection.
SCB972Hu CLIA Kit for Pigment Epithelium Derived Factor (PEDF) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB972Mu01 Recombinant Pigment Epithelium Derived Factor (PEDF) Positive Control; Immunogen; SDS-PAGE; WB.
RPB972Mu02 Recombinant Pigment Epithelium Derived Factor (PEDF) Positive Control; Immunogen; SDS-PAGE; WB.
RPB972Mu03 Recombinant Pigment Epithelium Derived Factor (PEDF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB972Mu01 Polyclonal Antibody to Pigment Epithelium Derived Factor (PEDF) WB; IHC; ICC; IP.
PAB972Mu02 Polyclonal Antibody to Pigment Epithelium Derived Factor (PEDF) WB; IHC; ICC; IP.
PAB972Mu03 Polyclonal Antibody to Pigment Epithelium Derived Factor (PEDF) WB; IHC; ICC; IP.
LAB972Mu71 Biotin-Linked Polyclonal Antibody to Pigment Epithelium Derived Factor (PEDF) WB; IHC; ICC.
LAB972Mu81 FITC-Linked Polyclonal Antibody to Pigment Epithelium Derived Factor (PEDF) WB; IHC; ICC; IF.
MAB972Mu21 Monoclonal Antibody to Pigment Epithelium Derived Factor (PEDF) WB,IHC
MAB972Mu22 Monoclonal Antibody to Pigment Epithelium Derived Factor (PEDF) WB; IHC; ICC; IP.
Assay Kits SEB972Mu ELISA Kit for Pigment Epithelium Derived Factor (PEDF) Enzyme-linked immunosorbent assay for Antigen Detection.
SCB972Mu CLIA Kit for Pigment Epithelium Derived Factor (PEDF) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB972Ra01 Recombinant Pigment Epithelium Derived Factor (PEDF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB972Ra01 Polyclonal Antibody to Pigment Epithelium Derived Factor (PEDF) WB; IHC; ICC; IP.
MAB972Ra21 Monoclonal Antibody to Pigment Epithelium Derived Factor (PEDF) WB; IHC; ICC; IP.
Assay Kits SEB972Ra ELISA Kit for Pigment Epithelium Derived Factor (PEDF) Enzyme-linked immunosorbent assay for Antigen Detection.
SCB972Ra CLIA Kit for Pigment Epithelium Derived Factor (PEDF) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB972Rb01 Recombinant Pigment Epithelium Derived Factor (PEDF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Pigment Epithelium Derived Factor (PEDF) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Pigment Epithelium Derived Factor (PEDF) Polyclonal Antibody Customized Service Offer
Assay Kits SEB972Rb ELISA Kit for Pigment Epithelium Derived Factor (PEDF) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB972Bo01 Recombinant Pigment Epithelium Derived Factor (PEDF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB972Bo01 Polyclonal Antibody to Pigment Epithelium Derived Factor (PEDF) WB; IHC; ICC; IP.
MAB972Bo21 Monoclonal Antibody to Pigment Epithelium Derived Factor (PEDF) WB; IHC; ICC; IP.
Assay Kits SEB972Bo ELISA Kit for Pigment Epithelium Derived Factor (PEDF) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Pigment epithelium-derived factor: neurotrophic activity and identification as a member of the serine protease inhibitor gene family."Proc. Natl. Acad. Sci. U.S.A. 90:1526-1530(1993) [PubMed] [Europe PMC] [Abstract]
  2. "Organization, evolutionary conservation, expression and unusual Alu density of the human gene for pigment epithelium-derived factor, a unique neurotrophic serpin."Mol. Vis. 2:11-11(1996) [PubMed] [Europe PMC] [Abstract]
  3. "Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method."Invest. Ophthalmol. Vis. Sci. 52:6662-6670(2011) [PubMed] [Europe PMC] [Abstract]
  4. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. Thesis (1996), Medical College of Pennsylvania, United States
  7. "Pigment-epithelium-derived factor (PEDF) occurs at a physiologically relevant concentration in human blood: purification and characterization."Biochem. J. 374:199-206(2003) [PubMed] [Europe PMC] [Abstract]
  8. "Senescent WI-38 cells fail to express EPC-1, a gene induced in young cells upon entry into the G0 state."J. Biol. Chem. 268:8949-8957(1993) [PubMed] [Europe PMC] [Abstract]
  9. "Overexpression of fetal human pigment epithelium-derived factor in Escherichia coli. A functionally active neurotrophic factor."J. Biol. Chem. 268:23148-23156(1993) [PubMed] [Europe PMC] [Abstract]
  10. "Pigment epithelium-derived factor behaves like a noninhibitory serpin. Neurotrophic activity does not require the serpin reactive loop."J. Biol. Chem. 270:25992-25999(1995) [PubMed] [Europe PMC] [Abstract]
  11. "Extracellular phosphorylation converts pigment epithelium-derived factor from a neurotrophic to an antiangiogenic factor."Blood 105:670-678(2005) [PubMed] [Europe PMC] [Abstract]
  12. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
  13. "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes."J. Proteome Res. 5:3135-3144(2006) [PubMed] [Europe PMC] [Abstract]
  14. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  15. "A strategy for precise and large scale identification of core fucosylated glycoproteins."Mol. Cell. Proteomics 8:913-923(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Enrichment of glycopeptides for glycan structure and attachment site identification."Nat. Methods 6:809-811(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Exome sequencing identifies truncating mutations in human SERPINF1 in autosomal-recessive osteogenesis imperfecta."Am. J. Hum. Genet. 88:362-371(2011) [PubMed] [Europe PMC] [Abstract]
  18. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  19. "Resveratrol-induced changes of the human adipocyte secretion profile."J. Proteome Res. 11:4733-4743(2012) [PubMed] [Europe PMC] [Abstract]
  20. "Crystal structure of human PEDF, a potent anti-angiogenic and neurite growth-promoting factor."Proc. Natl. Acad. Sci. U.S.A. 98:11131-11135(2001) [PubMed] [Europe PMC] [Abstract]
  21. "Four polymorphic variations in the PEDF gene identified during the mutation screening of patients with Leber congenital amaurosis."Mol. Vis. 5:10-10(1999) [PubMed] [Europe PMC] [Abstract]
  22. "Quantitative detection of single amino acid polymorphisms by targeted proteomics."J. Mol. Cell Biol. 3:309-315(2011) [PubMed] [Europe PMC] [Abstract]