Allopregnanolone (AP)

[Edit]

THP; 3a,5a-Tetrahydro Progesterone

CCC	B963
CAS	516-54-1
Wiki	THP

Allopregnanolone, also known as 3α,5α-tetrahydroprogesterone or THP, is an important neurosteroid in the human brain. It is a metabolite of progesterone and a barbiturate-like modulator of central gamma-aminobutyric acid (GABA) receptors that modify a range of behaviors, including the stress response.

The 5β epimer of this compound is known as pregnanolone, and has very similar properties to allopregnanolone. Both compounds are found endogenously and have similar hypnotic and anxiolytic effects.

The production of allopregnanolone starts with 5-alpha-reductase converting progesterone into pregnanolone. After that, 3beta-hydroxy-5alpha-steroid dehydrogenase converts the former into allopregnanolone.

Organism species: Pan-species (General)

	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	CPB963Ge11	BSA Conjugated Allopregnanolone (AP)	Immunogen; SDS-PAGE; WB.
Proteins	CPB963Ge21	OVA Conjugated Allopregnanolone (AP)	Immunogen; SDS-PAGE; WB.
Antibodies	PAB963Ge01	Polyclonal Antibody to Allopregnanolone (AP)	WB; IHC; ICC; IP.
	MAB963Ge21	Monoclonal Antibody to Allopregnanolone (AP)	ELISA, CLIA. / IHC-Fr, ICC, IP (predicted).
	MAB963Ge22	Monoclonal Antibody to Allopregnanolone (AP)	ELISA, CLIA. / IHC-Fr, ICC, IP (predicted).
	MAB963Ge24	Monoclonal Antibody to Allopregnanolone (AP)	ELISA, CLIA. / IHC-Fr, ICC, IP (predicted).
Assay Kits	CEB963Ge	ELISA Kit for Allopregnanolone (AP)	Enzyme-linked immunosorbent assay for Antigen Detection.