Arylalkylamine-N-Acetyltransferase (AANAT)
[Edit]AA-NAT; SNAT; Aralkylamine N-Acetyltransferase; Serotonin Acetyltransferase; Serotonin Acetylase; Serotonin N-Acetyltransferase; Melatonin Rhythm Enzyme
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Serotonin N-acetyl transferase is an enzyme involved in the conversion of serotonin to melatonin in pinealocytes. It is an acetyl-CoA dependent enzyme of the GCN5-related family of N-acetyltransferases (GNATs). Arylalkylamine N-acetyltransferase is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for seasonal reproduction, modulates the function of the circadian clock in the suprachiasmatic nucleus, and influences activity and sleep. This enzyme is rapidly inactivated when animals are exposed to light at night. This protein is 80% identical to sheep and rat AA-NAT. Arylalkylamine N-acetyltransferase may contribute a multifactorial genetic diseases such as altered behavior in sleep/wake cycle.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPB937Hu01 | Recombinant Arylalkylamine-N-Acetyltransferase (AANAT) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAB937Hu01 | Polyclonal Antibody to Arylalkylamine-N-Acetyltransferase (AANAT) | WB; IHC; ICC; IP. |
| MAB937Hu22 | Monoclonal Antibody to Arylalkylamine-N-Acetyltransferase (AANAT) | WB; IHC; ICC; IP. | |
| Assay Kits | SEB937Hu | ELISA Kit for Arylalkylamine-N-Acetyltransferase (AANAT) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPB937Mu01 | Recombinant Arylalkylamine-N-Acetyltransferase (AANAT) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAB937Mu01 | Polyclonal Antibody to Arylalkylamine-N-Acetyltransferase (AANAT) | WB; IHC; ICC; IP. |
| Assay Kits | n/a | CLIA Kit for Arylalkylamine-N-Acetyltransferase (AANAT) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Arylalkylamine-N-Acetyltransferase (AANAT) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPB937Ra01 | Recombinant Arylalkylamine-N-Acetyltransferase (AANAT) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAB937Ra01 | Polyclonal Antibody to Arylalkylamine-N-Acetyltransferase (AANAT) | WB; IHC; ICC; IP. |
| Assay Kits | n/a | CLIA Kit for Arylalkylamine-N-Acetyltransferase (AANAT) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Arylalkylamine-N-Acetyltransferase (AANAT) | ELISA Kit Customized Service Offer |
- "The human serotonin N-acetyltransferase (EC 2.3.1.87) gene (AANAT): structure, chromosomal localization, and tissue expression."Genomics 34:76-84(1996) [PubMed] [Europe PMC] [Abstract]
- "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "cAMP regulation of arylalkylamine N-acetyltransferase (AANAT, EC 2.3.1.87): a new cell line (1E7) provides evidence of intracellular AANAT activation."J. Biol. Chem. 276:24097-24107(2001) [PubMed] [Europe PMC] [Abstract]
- "Role of a pineal cAMP-operated arylalkylamine N-acetyltransferase/14-3-3-binding switch in melatonin synthesis."Proc. Natl. Acad. Sci. U.S.A. 98:8083-8088(2001) [PubMed] [Europe PMC] [Abstract]
- "Role of melatonin in upper gastrointestinal tract."J. Physiol. Pharmacol. 58:23-52(2007) [PubMed] [Europe PMC] [Abstract]
- "Significant association of the arylalkylamine N-acetyltransferase (AA-NAT) gene with delayed sleep phase syndrome."Neurogenetics 4:151-153(2003) [PubMed] [Europe PMC] [Abstract]