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Tenascin X (TNX)

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TN-X; TNXB; TNX-B; TNXA; TNX-A; TNXB1; TNXB2; HXBL; Hexabrachion-like protein

Tenascin X (TNX)
CCC B935
HGNC 11976
MGI 1932137
PubMed 16278880
UniProt P22105
Wiki Tenascin_X

Tenascin X is a member of the tenascin family of extracellular matrix glycoproteins. The tenascins have anti-adhesive effects, as opposed to fibronectin which is adhesive. This protein is thought to function in matrix maturation during wound healing, and its deficiency has been associated with the connective tissue disorder Ehlers-Danlos syndrome. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. It is one of four genes in this cluster which have been duplicated. The duplicated copy of this gene is incomplete and is a pseudogene which is transcribed but does not encode a protein. The structure of this gene is unusual in that it overlaps the CREBL1 and CYP21A2 genes at its 5' and 3' ends, respectively. Multiple transcript variants encoding different isoforms have been found for this gene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB935Hu01 Recombinant Tenascin X (TNX) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB935Hu01 Polyclonal Antibody to Tenascin X (TNX) WB; IHC
MAB935Hu22 Monoclonal Antibody to Tenascin X (TNX) WB; IHC; ICC; IP.
Assay Kits SEB935Hu ELISA Kit for Tenascin X (TNX) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB935Mu01 Recombinant Tenascin X (TNX) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB935Mu01 Polyclonal Antibody to Tenascin X (TNX) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Tenascin X (TNX) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tenascin X (TNX) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB935Ra01 Recombinant Tenascin X (TNX) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Tenascin X (TNX) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tenascin X (TNX) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tenascin X (TNX) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tenascin X (TNX) ELISA Kit Customized Service Offer
  1. "Sequences promoting the transcription of the human XA gene overlapping P450c21A correctly predict the presence of a novel, adrenal-specific, truncated form of tenascin-X."Genomics 28:171-178(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse."Genome Res. 13:2621-2636(2003) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Tenascin-X: a novel extracellular matrix protein encoded by the human XB gene overlapping P450c21B."J. Cell Biol. 122:265-278(1993) [PubMed] [Europe PMC] [Abstract]
  6. "Alternate promoters and alternate splicing of human tenascin-X, a gene with 5' and 3' ends buried in other genes."Hum. Mol. Genet. 5:1749-1758(1996) [PubMed] [Europe PMC] [Abstract]
  7. "Cluster of fibronectin type III repeats found in the human major histocompatibility complex class III region shows the highest homology with the repeats in an extracellular matrix protein, tenascin."Genomics 12:485-491(1992) [PubMed] [Europe PMC] [Abstract]
  8. "Identification and characterization of multiple species of tenascin-X in human serum."FEBS J. 274:1280-1289(2007) [PubMed] [Europe PMC] [Abstract]
  9. "Transcript encoded on the opposite strand of the human steroid 21-hydroxylase/complement component C4 gene locus."Proc. Natl. Acad. Sci. U.S.A. 86:6582-6586(1989) [PubMed] [Europe PMC] [Abstract]
  10. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
  11. "Interactions of human tenascin-X domains with dermal extracellular matrix molecules."Arch. Dermatol. Res. 298:389-396(2007) [PubMed] [Europe PMC] [Abstract]
  12. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  14. "Solution structure of the 29th, 31st and 33rd fibronectin type-III domains of the human tenascin-X."Submitted (NOV-2005) to the PDB data bank
  15. "A recessive form of the Ehlers-Danlos syndrome caused by tenascin-X deficiency."N. Engl. J. Med. 345:1167-1175(2001) [PubMed] [Europe PMC] [Abstract]
  16. "Elastic fiber abnormalities in hypermobility type Ehlers-Danlos syndrome patients with tenascin-X mutations."Clin. Genet. 67:330-334(2005) [PubMed] [Europe PMC] [Abstract]
  17. "Compound heterozygous mutations of the TNXB gene cause primary myopathy."Neuromuscul. Disord. 23:664-669(2013) [PubMed] [Europe PMC] [Abstract]
  18. "TNXB mutations can cause vesicoureteral reflux." J. Am. Soc. Nephrol. 24:1313-1322(2013) [PubMed] [Europe PMC] [Abstract]