p53 Upregulated Modulator Of Apoptosis (PUMA)

[Edit]

JFY1; BBC3; BCL2 Binding Component 3

p53 Upregulated Modulator Of Apoptosis (PUMA)

The p53 upregulated modulator of apoptosis, or PUMA, is a pro-apoptotic member of the Bcl-2 protein family.Bcl-2 family members can form hetero- or homodimers, and they act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The expression of PUMA is regulated by the tumor suppressor p53, and PUMA has been shown to be involved in p53-mediated apoptosis.Genomic sequence analysis revealed that the PUMA transcript is contained within 4 exons, with the presumptive initiation codon in exon 2. The predicted 193-amino acid PUMA protein shares 91% amino acid identity with the murine sequence. PUMA protein is exclusively mitochondrial and binds to BCL2 and BCLXL through a BH3 domain.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB909Hu01 Recombinant p53 Upregulated Modulator Of Apoptosis (PUMA) Positive Control; Immunogen; SDS-PAGE; WB.
CPB909Hu21 OVA Conjugated p53 Upregulated Modulator Of Apoptosis (PUMA) Immunogen; SDS-PAGE; WB.
Antibodies PAB909Hu01 Polyclonal Antibody to p53 Upregulated Modulator Of Apoptosis (PUMA) WB; IHC; ICC; IP.
MAB909Hu22 Monoclonal Antibody to p53 Upregulated Modulator Of Apoptosis (PUMA) WB; IHC; ICC; IP.
Assay Kits SEB909Hu ELISA Kit for p53 Upregulated Modulator Of Apoptosis (PUMA) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant p53 Upregulated Modulator Of Apoptosis (PUMA) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to p53 Upregulated Modulator Of Apoptosis (PUMA) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to p53 Upregulated Modulator Of Apoptosis (PUMA) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for p53 Upregulated Modulator Of Apoptosis (PUMA) CLIA Kit Customized Service Offer
n/a ELISA Kit for p53 Upregulated Modulator Of Apoptosis (PUMA) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB909Ra01 Recombinant p53 Upregulated Modulator Of Apoptosis (PUMA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB909Ra01 Polyclonal Antibody to p53 Upregulated Modulator Of Apoptosis (PUMA) WB; IHC; ICC; IP.
MAB909Ra21 Monoclonal Antibody to p53 Upregulated Modulator Of Apoptosis (PUMA) WB; IHC; ICC; IP.
Assay Kits SEB909Ra ELISA Kit for p53 Upregulated Modulator Of Apoptosis (PUMA) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "PUMA induces the rapid apoptosis of colorectal cancer cells."Mol. Cell 7:673-682(2001) [PubMed] [Europe PMC] [Abstract]
  2. "PUMA, a novel proapoptotic gene, is induced by p53."Mol. Cell 7:683-694(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Expression of bbc3, a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals."Proc. Natl. Acad. Sci. U.S.A. 98:11318-11323(2001) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  6. "CHOP potentially co-operates with FOXO3a in neuronal cells to regulate PUMA and BIM expression in response to ER stress."PLoS ONE 7:E39586-E39586(2012) [PubMed] [Europe PMC] [Abstract]
  7. "PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosis."Nat. Chem. Biol. 9:163-168(2013) [PubMed] [Europe PMC] [Abstract]