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Prekallikrein (PK)

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KLKB1; KLK3; Fletcher Factor; Kallikrein B,Plasma; Kininogenin; Plasma prekallikrein

Prekallikrein (PK)
CCC B801
HGNC 6371
MGI 102849
PubMed 21091145
RGD 67382
UniProt P03952
Wiki Prekallikrein

Prekallikrein (PK), also known as Fletcher factor, is a 85,000 Mr serine protease that complexes with HK. Plasma prekallikrein is a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. It is synthesized in the liver and secreted into the blood as a single polypeptide chain.

Plasma prekallikrein is converted to plasma kallikrein by factor XIIa by the cleavage of an internal Arg-Ile bond. Plasma kallikrein therefore is composed of a heavy chain and a light chain held together by a disulfide bond. The heavy chain originates from the amino-terminal end of the zymogen and contains 4 tandem repeats of 90 or 91 amino acids. Each repeat harbors a novel structure called the apple domain.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB801Hu01 Recombinant Prekallikrein (PK) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB801Hu01 Polyclonal Antibody to Prekallikrein (PK) WB; IHC; ICC; IP.
MAB801Hu22 Monoclonal Antibody to Prekallikrein (PK) WB; IHC; ICC; IP.
Assay Kits SEB801Hu ELISA Kit for Prekallikrein (PK) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Prekallikrein (PK) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Prekallikrein (PK) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Prekallikrein (PK) Polyclonal Antibody Customized Service Offer
Assay Kits SEB801Mu ELISA Kit for Prekallikrein (PK) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins EPB801Ra61 Eukaryotic Prekallikrein (PK) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Prekallikrein (PK) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Prekallikrein (PK) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Prekallikrein (PK) CLIA Kit Customized Service Offer
n/a ELISA Kit for Prekallikrein (PK) ELISA Kit Customized Service Offer
  1. "Human plasma prekallikrein, a zymogen to a serine protease that contains four tandem repeats."Biochemistry 25:2410-2417(1986) [PubMed] [Europe PMC] [Abstract]
  2. "Genomic structure of the human plasma prekallikrein gene, identification of allelic variants, and analysis in end-stage renal disease."Genomics 69:225-234(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
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  6. "Location of the disulfide bonds in human plasma prekallikrein: the presence of four novel apple domains in the amino-terminal portion of the molecule."Biochemistry 30:2050-2056(1991) [PubMed] [Europe PMC] [Abstract]
  7. "Inactivation of human plasma kallikrein and factor XIa by protein C inhibitor."Biochemistry 27:4231-4237(1988) [PubMed] [Europe PMC] [Abstract]
  8. "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry."Nat. Biotechnol. 21:660-666(2003) [PubMed] [Europe PMC] [Abstract]
  9. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Severe prekallikrein (Fletcher factor) deficiency due to a compound heterozygosis (383Trp stop codon and Cys529Tyr)."Thromb. Haemost. 90:1040-1045(2003) [PubMed] [Europe PMC] [Abstract]
  12. "A new type of plasma prekallikrein deficiency associated with homozygosity for Gly104Arg and Asn124Ser in apple domain 2 of the heavy-chain region."Eur. J. Haematol. 79:59-68(2007) [PubMed] [Europe PMC] [Abstract]