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S100 Calcium Binding Protein A8 (S100A8)

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MRP8; MIF; 60B8AG; CAGA; CFAG; CGLA; CP-10; L1Ag; NIF; P8; Calgranulin A; Cystic fibrosis antigen; Leukocyte L1 complex light chain; Migration inhibitory factor-related protein 8

S100 Calcium Binding Protein A8 (S100A8)
CCC B792
HGNC 10498
MGI 88244
PubMed 16931866
RGD 620265
UniProt P05109
Wiki S100A8

S100A8, a protein associated with a wide variety of inflammatory conditions, is heavily over-expressed in association with inflammation. Human S100A8 possesses neutrophil-repelling properties that result in an anti-inflammatory effect in vivo. The chemotactic activity of S100A8 on neutrophils was tested in Transwell chemotaxis assays. Analysis of the data indicates that S100A8 causes a repulsion of peripheral neutrophils, an activity that S100A8 loses upon its oxidation. S100A8 causes a strong anti-inflammatory effect in the rat air-pouch model of inflammation in vivo. These data highlight a naturally occurring novel anti-inflammatory pathway and provide potential molecular targets for the development of novel anti-inflammatory therapeutics.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB792Hu01 Recombinant S100 Calcium Binding Protein A8 (S100A8) Positive Control; Immunogen; SDS-PAGE; WB.
RPB792Hu02 Recombinant S100 Calcium Binding Protein A8 (S100A8) Positive Control; Immunogen; SDS-PAGE; WB.
APB792Hu01 Active S100 Calcium Binding Protein A8 (S100A8) Cell culture; Activity Assays.
Antibodies PAB792Hu01 Polyclonal Antibody to S100 Calcium Binding Protein A8 (S100A8) WB; IHC; ICC; IP.
LAB792Hu71 Biotin-Linked Polyclonal Antibody to S100 Calcium Binding Protein A8 (S100A8) WB; IHC; ICC.
LAB792Hu81 FITC-Linked Polyclonal Antibody to S100 Calcium Binding Protein A8 (S100A8) WB; IHC; ICC; IF.
MAB792Hu21 Monoclonal Antibody to S100 Calcium Binding Protein A8 (S100A8) WB; IHC.
PAB792Hu02 Polyclonal Antibody to S100 Calcium Binding Protein A8 (S100A8) WB; IHC; ICC; IP.
MAB792Hu24 Monoclonal Antibody to S100 Calcium Binding Protein A8 (S100A8) WB; ICC/IF
MAB792Hu22 Monoclonal Antibody to S100 Calcium Binding Protein A8 (S100A8) WB; IHC; ICC; IP.
MAB792Hu23 Monoclonal Antibody to S100 Calcium Binding Protein A8 (S100A8) WB; IHC; ICC; IP.
MAB792Hu25 Monoclonal Antibody to S100 Calcium Binding Protein A8 (S100A8) WB; IHC; ICC; IP.
MAB792Hu26 Monoclonal Antibody to S100 Calcium Binding Protein A8 (S100A8) WB; IHC; ICC; IP.
MAB792Hu28 Monoclonal Antibody to S100 Calcium Binding Protein A8 (S100A8) WB; IHC; ICC; IP.
MAB792Hu27 Monoclonal Antibody to S100 Calcium Binding Protein A8 (S100A8) WB; IHC; ICC; IP.
MAB792Hu29 Monoclonal Antibody to S100 Calcium Binding Protein A8 (S100A8) WB; IHC; ICC; IP.
Assay Kits SEB792Hu ELISA Kit for S100 Calcium Binding Protein A8 (S100A8) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB792Mu01 Recombinant S100 Calcium Binding Protein A8 (S100A8) Positive Control; Immunogen; SDS-PAGE; WB.
RPB792Mu02 Recombinant S100 Calcium Binding Protein A8 (S100A8) Positive Control; Immunogen; SDS-PAGE; WB.
EPB792Mu61 Eukaryotic S100 Calcium Binding Protein A8 (S100A8) Positive Control; Immunogen; SDS-PAGE; WB.
APB792Mu61 Active S100 Calcium Binding Protein A8 (S100A8) Cell culture; Activity Assays.
Antibodies PAB792Mu01 Polyclonal Antibody to S100 Calcium Binding Protein A8 (S100A8) WB; IHC; ICC; IP.
LAB792Mu71 Biotin-Linked Polyclonal Antibody to S100 Calcium Binding Protein A8 (S100A8) WB; IHC; ICC.
LAB792Mu81 FITC-Linked Polyclonal Antibody to S100 Calcium Binding Protein A8 (S100A8) WB; IHC; ICC; IF.
PAB792Mu02 Polyclonal Antibody to S100 Calcium Binding Protein A8 (S100A8) WB; IHC; ICC; IP.
MAB792Mu21 Monoclonal Antibody to S100 Calcium Binding Protein A8 (S100A8) WB; IHC; ICC; IP.
Assay Kits SEB792Mu ELISA Kit for S100 Calcium Binding Protein A8 (S100A8) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB792Ra01 Recombinant S100 Calcium Binding Protein A8 (S100A8) Positive Control; Immunogen; SDS-PAGE; WB.
APB792Ra01 Active S100 Calcium Binding Protein A8 (S100A8) Cell culture; Activity Assays.
Antibodies PAB792Ra01 Polyclonal Antibody to S100 Calcium Binding Protein A8 (S100A8) WB; IHC; ICC; IP.
LAB792Ra71 Biotin-Linked Polyclonal Antibody to S100 Calcium Binding Protein A8 (S100A8) WB; IHC; ICC.
LAB792Ra81 FITC-Linked Polyclonal Antibody to S100 Calcium Binding Protein A8 (S100A8) WB; IHC; ICC; IF.
MAB792Ra21 Monoclonal Antibody to S100 Calcium Binding Protein A8 (S100A8) WB; IHC; ICC; IP.
Assay Kits SEB792Ra ELISA Kit for S100 Calcium Binding Protein A8 (S100A8) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB792Rb01 Recombinant S100 Calcium Binding Protein A8 (S100A8) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB792Rb51 Polyclonal Antibody to S100 Calcium Binding Protein A8 (S100A8) WB; IHC; ICC; IP.
PAB792Rb01 Polyclonal Antibody to S100 Calcium Binding Protein A8 (S100A8) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for S100 Calcium Binding Protein A8 (S100A8) CLIA Kit Customized Service Offer
n/a ELISA Kit for S100 Calcium Binding Protein A8 (S100A8) ELISA Kit Customized Service Offer

Organism species: Canis familiaris; Canine (Dog)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB792Ca01 Recombinant S100 Calcium Binding Protein A8 (S100A8) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB792Ca01 Polyclonal Antibody to S100 Calcium Binding Protein A8 (S100A8) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for S100 Calcium Binding Protein A8 (S100A8) CLIA Kit Customized Service Offer
n/a ELISA Kit for S100 Calcium Binding Protein A8 (S100A8) ELISA Kit Customized Service Offer

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB792Po01 Recombinant S100 Calcium Binding Protein A8 (S100A8) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB792Po01 Polyclonal Antibody to S100 Calcium Binding Protein A8 (S100A8) WB; IHC; ICC; IP.
Assay Kits SEB792Po ELISA Kit for S100 Calcium Binding Protein A8 (S100A8) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB792Bo01 Recombinant S100 Calcium Binding Protein A8 (S100A8) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB792Bo01 Polyclonal Antibody to S100 Calcium Binding Protein A8 (S100A8) WB; IHC; ICC; IP.
LAB792Bo71 Biotin-Linked Polyclonal Antibody to S100 Calcium Binding Protein A8 (S100A8) WB; IHC; ICC.
LAB792Bo81 FITC-Linked Polyclonal Antibody to S100 Calcium Binding Protein A8 (S100A8) WB; IHC; ICC; IF.
MAB792Bo21 Monoclonal Antibody to S100 Calcium Binding Protein A8 (S100A8) WB; IHC; ICC; IP.
Assay Kits SEB792Bo ELISA Kit for S100 Calcium Binding Protein A8 (S100A8) Enzyme-linked immunosorbent assay for Antigen Detection.
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  20. "Regulation of S100A8/A9 (calprotectin) binding to tumor cells by zinc ion and its implication for apoptosis-inducing activity."Mediators Inflamm. 2005:280-292(2005) [PubMed] [Europe PMC] [Abstract]
  21. "Interaction between S100A8/A9 and annexin A6 is involved in the calcium-induced cell surface exposition of S100A8/A9."J. Biol. Chem. 283:31776-31784(2008) [PubMed] [Europe PMC] [Abstract]
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  23. "Anti-infective protective properties of S100 calgranulins."Antiinflamm. Antiallergy Agents Med. Chem. 8:290-305(2009) [PubMed] [Europe PMC] [Abstract]
  24. "S100A8/A9: a Janus-faced molecule in cancer therapy and tumorgenesis."Eur. J. Pharmacol. 625:73-83(2009) [PubMed] [Europe PMC] [Abstract]
  25. "Substitution of methionine 63 or 83 in S100A9 and cysteine 42 in S100A8 abrogate the antifungal activities of S100A8/A9: potential role for oxidative regulation."FEMS Immunol. Med. Microbiol. 55:55-61(2009) [PubMed] [Europe PMC] [Abstract]
  26. "Calprotectin S100A9 calcium-binding loops I and II are essential for keratinocyte resistance to bacterial invasion."J. Biol. Chem. 284:7078-7090(2009) [PubMed] [Europe PMC] [Abstract]
  27. "The endogenous Toll-like receptor 4 agonist S100A8/S100A9 (calprotectin) as innate amplifier of infection, autoimmunity, and cancer."J. Leukoc. Biol. 86:557-566(2009) [PubMed] [Europe PMC] [Abstract]
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  41. "The crystal structure of the human (S100A8/S100A9)2 heterotetramer, calprotectin, illustrates how conformational changes of interacting alpha-helices can determine specific association of two EF-hand proteins."J. Mol. Biol. 370:887-898(2007) [PubMed] [Europe PMC] [Abstract]