Cluster Of Differentiation 7 (CD7)
[Edit]GP40; LEU9; TP41; Tp40; p41 Protein; T-cell Antigen CD7; T-cell Leukemia Antigen; T-cell surface antigen Leu-9
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CD7 is a member of the immunoglobulin superfamily. This protein is found on thymocytes and mature T cells. It plays an essential role in T-cell interactions and also in T-cell/B-cell interaction during early lymphoid development.
The CD7 antigen is a cell surface glycoprotein found on thymocytes and mature T cells. It is one of the earliest antigens to appear on cells of the T-lymphocyte lineage and the most reliable clinical marker of T-cell acute lymphocytic leukemia. Aruffo and Seed (1987) isolated and sequenced a full-length CD7 cDNA as well as a cDNA for an unusual intron-bearing precursor. They found that COS cells expressing CD7 do not bind IgM. Schanberg et al. (1991) isolated and characterized the human CD7 gene and its 5-prime flanking region; the gene comprises 4 exons that span 3.5 kb.
Organism species: Homo sapiens (Human)
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPB784Mu01 | Recombinant Cluster Of Differentiation 7 (CD7) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAB784Mu01 | Polyclonal Antibody to Cluster Of Differentiation 7 (CD7) | WB; IHC; ICC; IP. |
| Assay Kits | n/a | CLIA Kit for Cluster Of Differentiation 7 (CD7) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Cluster Of Differentiation 7 (CD7) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPB784Ra01 | Recombinant Cluster Of Differentiation 7 (CD7) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAB784Ra01 | Polyclonal Antibody to Cluster Of Differentiation 7 (CD7) | WB; IHC; ICC; IP. |
| Assay Kits | n/a | CLIA Kit for Cluster Of Differentiation 7 (CD7) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Cluster Of Differentiation 7 (CD7) | ELISA Kit Customized Service Offer |
- "Molecular cloning of two CD7 (T-cell leukemia antigen) cDNAs by a COS cell expression system."EMBO J. 6:3313-3316(1987) [PubMed] [Europe PMC] [Abstract]
- "Isolation and characterization of the genomic human CD7 gene: structural similarity with the murine Thy-1 gene."Proc. Natl. Acad. Sci. U.S.A. 88:603-607(1991) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Molecular cloning of the gene coding for the human T cell differentiation antigen CD7."Immunogenetics 33:352-360(1991) [PubMed] [Europe PMC] [Abstract]
- "Characterization of the surface topography and putative tertiary structure of the human CD7 molecule."J. Immunol. 143:3632-3640(1989) [PubMed] [Europe PMC] [Abstract]
- "Identification of CD7 as a cognate of the human K12 (SECTM1) protein."J. Biol. Chem. 275:3431-3437(2000) [PubMed] [Europe PMC] [Abstract]
- "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
- "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
- "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]