Oncoprotein Induced Transcript 3 (OIT3)
[Edit]LZP; Liver-specific zona pellucida domain-containing protein
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OIT3 contains one EGF-like domain and one ZP domain. It may be involved in hepatocellular function and development. OIT3 is liver-specific and is expressed only in the hepatocytes; down-regulated in hepatocellular carcinoma (HCC) and HCC cell lines. LZP contains an N-terminal signal peptide, followed by 3 epidermal growth factor (EGF)-like domains and a zona pellucida (ZP) domain in its C-terminal region. LZP also contains several N-glycosylation sites.
The 546-amino acid mouse Lzp protein shares 89% identity with human LZP. Northern blot analysis of several human tissues detected a 2.4-kb transcript only in liver. Northern blot analysis of whole mouse embryos detected 2 Lzp variants that differed in the length of the UTR and the poly(A) signal used.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPB729Hu01 | Recombinant Oncoprotein Induced Transcript 3 (OIT3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAB729Hu01 | Polyclonal Antibody to Oncoprotein Induced Transcript 3 (OIT3) | WB,IHC |
| MAB729Hu22 | Monoclonal Antibody to Oncoprotein Induced Transcript 3 (OIT3) | WB; IHC; ICC; IP. | |
| Assay Kits | SEB729Hu | ELISA Kit for Oncoprotein Induced Transcript 3 (OIT3) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPB729Mu01 | Recombinant Oncoprotein Induced Transcript 3 (OIT3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | n/a | Monoclonal Antibody to Oncoprotein Induced Transcript 3 (OIT3) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Oncoprotein Induced Transcript 3 (OIT3) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Oncoprotein Induced Transcript 3 (OIT3) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Oncoprotein Induced Transcript 3 (OIT3) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPB729Ra01 | Recombinant Oncoprotein Induced Transcript 3 (OIT3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAB729Ra01 | Polyclonal Antibody to Oncoprotein Induced Transcript 3 (OIT3) | WB,IHC |
| Assay Kits | n/a | CLIA Kit for Oncoprotein Induced Transcript 3 (OIT3) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Oncoprotein Induced Transcript 3 (OIT3) | ELISA Kit Customized Service Offer |
- "A novel liver-specific zona pellucida domain containing protein that is expressed rarely in hepatocellular carcinoma."Hepatology 38:735-744(2003) [PubMed] [Europe PMC] [Abstract]
- "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]