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Glycophorin B (GYPB)

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CD235b; GYP-B; SS; PAS-3; MNS; GPB; GYPA; GPB.NY; GYPHe.NY; Sialoglycoprotein Delta And SS-active Sialoglycoprotein

Glycophorin B (GYPB)
CCC B713
HGNC 4703
PubMed 8078523
UniProt P06028
Wiki GYPB

  • Glycophorins A (GYPA) and B (GYPB) are major sialoglycoproteins of the human erythrocyte membrane which bear the antigenic determinants for the MN and Ss blood groups.

  • GYPB gene consists of 5 exons and has 97% sequence homology with GYPA from the 5' UTR to the coding sequence encoding the first 45 amino acids. In addition to the M or N and S or s antigens, that commonly occur in all populations, about 40 related variant phenotypes have been identified.

  • These variants include all the variants of the Miltenberger complex and several isoforms of Sta; also, Dantu, Sat, He, Mg, and deletion variants Ena, S-s-U- and Mk. Most of the variants are the result of gene recombinations between GYPA and GYPB.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Glycophorin B (GYPB) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Glycophorin B (GYPB) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Glycophorin B (GYPB) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Glycophorin B (GYPB) CLIA Kit Customized Service Offer
n/a ELISA Kit for Glycophorin B (GYPB) ELISA Kit Customized Service Offer
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  2. "Isolation of cDNA clones for human erythrocyte membrane sialoglycoproteins alpha and delta."Biochem. J. 254:743-750(1988) [PubMed] [Europe PMC] [Abstract]
  3. "Structural organization of glycophorin A and B genes: glycophorin B gene evolved by homologous recombination at Alu repeat sequences."Proc. Natl. Acad. Sci. U.S.A. 86:4619-4623(1989) [PubMed] [Europe PMC] [Abstract]
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  5. "The low-incidence MNS antigens M(v), s(D), and Mit arise from single amino acid substitutions on GPB."Transfusion 41:269-275(2001) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Molecular genetics of human erythrocyte MiIII and MiVI glycophorins. Use of a pseudoexon in construction of two delta-alpha-delta hybrid genes resulting in antigenic diversification."J. Biol. Chem. 266:7248-7255(1991) [PubMed] [Europe PMC] [Abstract]
  8. "Hybrid glycophorins from human erythrocyte membranes. I. Isolation and complete structural analysis of the hybrid sialoglycoprotein from Dantu-positive red cells of the N.E. variety."Eur. J. Biochem. 166:31-36(1987) [PubMed] [Europe PMC] [Abstract]
  9. "Glycophorins B and C from human erythrocyte membranes. Purification and sequence analysis."J. Biol. Chem. 262:5808-5811(1987) [PubMed] [Europe PMC] [Abstract]
  10. "Molecular basis for the human erythrocyte glycophorin specifying the Miltenberger class I (MiI) phenotype."Blood 80:257-263(1992) [PubMed] [Europe PMC] [Abstract]
  11. "Epitopic structure of Tn glycophorin A for an anti-Tn antibody (MLS 128)."Proc. Natl. Acad. Sci. U.S.A. 90:2495-2499(1993) [PubMed] [Europe PMC] [Abstract]