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Cluster Of Differentiation 146 (CD146)

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MCAM; MUC18; Melanoma Cell Adhesion Molecule; Cell surface glycoprotein P1H12; Melanoma-associated antigen A32; S-endo 1 endothelial-associated antigen

Cluster Of Differentiation 146 (CD146)
CCC B670
HGNC 6934
MGI 1933966
PubMed 9187135
RGD 620463
UniProt P43121
Wiki MCAM

CD146 (cluster of differentiation 146) is a 113kDa cell adhesion molecule currently used as a marker for endothelial cell lineage. In humans, the CD146 protein is encoded by the MCAM gene.
Its function is still poorly understood, but evidence points to it being part of the endothelial junction associated with the actin cytoskeleton. A member of the Immunoglobulin superfamily, it consists of five Ig domains, a transmembrane domain, and a cytoplasmic region. It is expressed on chicken embryonic spleen and thymus, activated human T cells, endothelial progenitors such as angioblasts and mesenchymal stem cells, and strongly expressed on blood vessel endothelium and smooth muscle.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB670Hu01 Recombinant Cluster Of Differentiation 146 (CD146) Positive Control; Immunogen; SDS-PAGE; WB.
APB670Hu01 Active Cluster Of Differentiation 146 (CD146) Cell culture; Activity Assays.
Antibodies PAB670Hu01 Polyclonal Antibody to Cluster Of Differentiation 146 (CD146) WB
MAB670Hu22 Monoclonal Antibody to Cluster Of Differentiation 146 (CD146) WB; IHC; ICC; IP.
Assay Kits SEB670Hu ELISA Kit for Cluster Of Differentiation 146 (CD146) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB670Mu01 Recombinant Cluster Of Differentiation 146 (CD146) Positive Control; Immunogen; SDS-PAGE; WB.
RPB670Mu02 Recombinant Cluster Of Differentiation 146 (CD146) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB670Mu01 Polyclonal Antibody to Cluster Of Differentiation 146 (CD146) WB; IHC; ICC; IP.
LAB670Mu81 FITC-Linked Polyclonal Antibody to Cluster Of Differentiation 146 (CD146) WB; IHC; ICC; IF.
LAB670Mu71 Biotin-Linked Polyclonal Antibody to Cluster Of Differentiation 146 (CD146) WB; IHC; ICC.
PAB670Mu02 Polyclonal Antibody to Cluster Of Differentiation 146 (CD146) WB; IHC; ICC; IP.
Assay Kits SEB670Mu ELISA Kit for Cluster Of Differentiation 146 (CD146) Enzyme-linked immunosorbent assay for Antigen Detection.
SCB670Mu CLIA Kit for Cluster Of Differentiation 146 (CD146) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB670Ra01 Recombinant Cluster Of Differentiation 146 (CD146) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB670Ra01 Polyclonal Antibody to Cluster Of Differentiation 146 (CD146) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Cluster Of Differentiation 146 (CD146) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cluster Of Differentiation 146 (CD146) ELISA Kit Customized Service Offer
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  11. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]