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Cluster Of Differentiation 226 (CD226)

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DNAM1; PTA1; TLiSA1; DNAX accessory molecule 1

Cluster Of Differentiation 226 (CD226)
CCC B669
HGNC 16961
MGI 3039602
PubMed 16987076
RGD 1311513
UniProt Q15762
Wiki CD226

CD226 is a ~65 kDa glycoprotein expressed on the surface of NK cells, platelets, monocytes and a subset of T cells. It is a member of the Ig-superfamily containing 2 Ig-like domains of the V-set and is encoded by a gene on human chromosome 18q22.3. CD226 mediates cellular adhesion to other cells bearing an unidentified ligand and cross-linking CD226 with antibodies causes cellular activation.

CD226 belongs to the immunoglobulin (Ig) superfamily and is expressed on the majority of natural killer (NK) cells, T cells, monocytes, and platelets. Through its interaction with various ligands, including LFA1, CD155 (PVR), and CD112 (PVRL2), CD226 plays an important role in T cell- and NK cell-mediated recognition and lysis of tumor cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB669Hu01 Recombinant Cluster Of Differentiation 226 (CD226) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB669Hu01 Polyclonal Antibody to Cluster Of Differentiation 226 (CD226) WB; IHC; ICC; IP.
MAB669Hu22 Monoclonal Antibody to Cluster Of Differentiation 226 (CD226) WB
MAB669Hu23 Monoclonal Antibody to Cluster Of Differentiation 226 (CD226) WB; IHC; ICC; IP.
MAB669Hu21 Monoclonal Antibody to Cluster Of Differentiation 226 (CD226) WB
MAB669Hu24 Monoclonal Antibody to Cluster Of Differentiation 226 (CD226) WB; IHC; ICC; IP.
Assay Kits SEB669Hu ELISA Kit for Cluster Of Differentiation 226 (CD226) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cluster Of Differentiation 226 (CD226) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cluster Of Differentiation 226 (CD226) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cluster Of Differentiation 226 (CD226) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cluster Of Differentiation 226 (CD226) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cluster Of Differentiation 226 (CD226) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cluster Of Differentiation 226 (CD226) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cluster Of Differentiation 226 (CD226) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cluster Of Differentiation 226 (CD226) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cluster Of Differentiation 226 (CD226) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cluster Of Differentiation 226 (CD226) ELISA Kit Customized Service Offer
  1. "DNAM-1, a novel adhesion molecule involved in the cytolytic function of T lymphocytes."Immunity 4:573-581(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "DNA sequence and analysis of human chromosome 18." Nature 437:551-555(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Functional characterization of DNAM-1 (CD226) interaction with its ligands PVR (CD155) and nectin-2 (PRR-2/CD112)."Int. Immunol. 16:533-538(2004) [PubMed] [Europe PMC] [Abstract]
  6. "PVR (CD155) and Nectin-2 (CD112) as ligands of the human DNAM-1 (CD226) activating receptor: involvement in tumor cell lysis."Mol. Immunol. 42:463-469(2005) [PubMed] [Europe PMC] [Abstract]
  7. "Phosphoproteome of resting human platelets."J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]