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B-Cell Linker Protein (BLNK)

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BASH; BLNK-s; Ly57; SLP65; B-Cell Adapter Containing A SH2 Domain Protein; Cytoplasmic adapter protein; Src homology 2 domain-containing leukocyte protein of 65 kDa

B-Cell Linker Protein (BLNK)
CCC B600
HGNC 14211
MGI 96878
PubMed 9697839
RGD 1561933
UniProt Q8WV28
Wiki BLNK

Fu et al. (1998) identified a novel BLNK encodes a 456-amino acid polypeptide with basic, acidic, proline-rich, and SH2 domains. An alternatively spliced product called BLNK-S lacks basepairs 760 to 828 within the proline-rich domain.

The murine Blnk protein shares 82% identity with human BLNK. There appeared to be no alternatively spliced form of mouse BLNK. BLNK shows greatest homology to the SLP76 (601603) linker protein. BLNK mRNA is predominantly expressed in the spleen, although some level of expression can be seen in liver, kidney, and pancreas. Expression of BLNK proteins was detected only in B-cell lines.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB600Hu01 Recombinant B-Cell Linker Protein (BLNK) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB600Hu01 Polyclonal Antibody to B-Cell Linker Protein (BLNK) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for B-Cell Linker Protein (BLNK) CLIA Kit Customized Service Offer
n/a ELISA Kit for B-Cell Linker Protein (BLNK) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant B-Cell Linker Protein (BLNK) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to B-Cell Linker Protein (BLNK) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to B-Cell Linker Protein (BLNK) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for B-Cell Linker Protein (BLNK) CLIA Kit Customized Service Offer
n/a ELISA Kit for B-Cell Linker Protein (BLNK) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant B-Cell Linker Protein (BLNK) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to B-Cell Linker Protein (BLNK) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to B-Cell Linker Protein (BLNK) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for B-Cell Linker Protein (BLNK) CLIA Kit Customized Service Offer
n/a ELISA Kit for B-Cell Linker Protein (BLNK) ELISA Kit Customized Service Offer
  1. "BLNK: a central linker protein in B cell activation."Immunity 9:93-103(1998) [PubMed] [Europe PMC] [Abstract]
  2. "An essential role for BLNK in human B cell development."Science 286:1954-1957(1999) [PubMed] [Europe PMC] [Abstract]
  3. "SLP65 deficiency results in perpetual V(D)J recombinase activity in pre-B-lymphoblastic leukemia and B-cell lymphoma cells."Oncogene 25:5180-5186(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Identification of two tyrosine phosphoproteins, pp70 and pp68, which interact with phospholipase Cgamma, Grb2, and Vav after B cell antigen receptor activation."J. Biol. Chem. 272:27362-27368(1997) [PubMed] [Europe PMC] [Abstract]
  7. "BLNK: molecular scaffolding through 'cis'-mediated organization of signaling proteins."EMBO J. 21:6461-6472(2002) [PubMed] [Europe PMC] [Abstract]
  8. "Deficiency of BLNK hampers PLC-gamma2 phosphorylation and Ca2+ influx induced by the pre-B-cell receptor in human pre-B cells."Immunology 112:575-582(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Human SLP-65 isoforms contribute differently to activation and apoptosis of B lymphocytes."Blood 108:3761-3768(2006) [PubMed] [Europe PMC] [Abstract]
  10. "The kinase Syk as an adaptor controlling sustained calcium signalling and B-cell development."EMBO J. 27:1333-1344(2008) [PubMed] [Europe PMC] [Abstract]
  11. "SCIMP, a transmembrane adapter protein involved in major histocompatibility complex class II signaling."Mol. Cell. Biol. 31:4550-4562(2011) [PubMed] [Europe PMC] [Abstract]