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Macrophage Scavenger Receptor 1 (MSR1)

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CD204; MSR1; SCARA1; SR-A; PhSR1; PhSR2; Macrophage acetylated LDL receptor I and II; Scavenger receptor class A member 1

Macrophage Scavenger Receptor 1 (MSR1)
CCC B591
HGNC 7376
MGI 98257
PubMed 16287155
RGD 1564316
UniProt P21757
Wiki MSR1

Macrophage scavenger receptor 1, also known as MSR1, is a protein which in humans is encoded by the MSR1 gene.MSR1 has also recently been designated CD204. This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene.

These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs).

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB591Hu01 Recombinant Macrophage Scavenger Receptor 1 (MSR1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB591Hu01 Polyclonal Antibody to Macrophage Scavenger Receptor 1 (MSR1) WB; IHC; ICC; IP.
MAB591Hu22 Monoclonal Antibody to Macrophage Scavenger Receptor 1 (MSR1) WB; IHC; ICC; IP.
Assay Kits SEB591Hu ELISA Kit for Macrophage Scavenger Receptor 1 (MSR1) Enzyme-linked immunosorbent assay for Antigen Detection.
SCB591Hu CLIA Kit for Macrophage Scavenger Receptor 1 (MSR1) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Macrophage Scavenger Receptor 1 (MSR1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Macrophage Scavenger Receptor 1 (MSR1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Macrophage Scavenger Receptor 1 (MSR1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Macrophage Scavenger Receptor 1 (MSR1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Macrophage Scavenger Receptor 1 (MSR1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Macrophage Scavenger Receptor 1 (MSR1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Macrophage Scavenger Receptor 1 (MSR1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Macrophage Scavenger Receptor 1 (MSR1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Macrophage Scavenger Receptor 1 (MSR1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Macrophage Scavenger Receptor 1 (MSR1) ELISA Kit Customized Service Offer
  1. "Human macrophage scavenger receptors: primary structure, expression, and localization in atherosclerotic lesions."Proc. Natl. Acad. Sci. U.S.A. 87:9133-9137(1990) [PubMed] [Europe PMC] [Abstract]
  2. "A naturally occurring isoform of the human macrophage scavenger receptor (SR-A) gene generated by alternative splicing blocks modified LDL uptake."J. Lipid Res. 39:531-543(1998) [PubMed] [Europe PMC] [Abstract]
  3. "DNA sequence and analysis of human chromosome 8." Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Structure, organization, and chromosomal mapping of the human macrophage scavenger receptor gene."J. Biol. Chem. 268:2120-2125(1993) [PubMed] [Europe PMC] [Abstract]
  6. "Structures of class A macrophage scavenger receptors. Electron microscopic study of flexible, multidomain, fibrous proteins and determination of the disulfide bond pattern of the scavenger receptor cysteine-rich domain."J. Biol. Chem. 271:26924-26930(1996) [PubMed] [Europe PMC] [Abstract]
  7. "Germline mutations and sequence variants of the macrophage scavenger receptor 1 gene are associated with prostate cancer risk." Nat. Genet. 32:321-325(2002) [PubMed] [Europe PMC] [Abstract]
  8. "An unappreciated role for RNA surveillance."Genome Biol. 5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Germline mutations in MSR1, ASCC1, and CTHRC1 in patients with Barrett esophagus and esophageal adenocarcinoma."JAMA 306:410-419(2011) [PubMed] [Europe PMC] [Abstract]