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Integrin Beta 2 (CD18)

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ITGb2; ITG-B2; LAD; LFA1; MAC1; LCAMB; MF17; LFAb; Complement Component 3 Receptor 3 And 4 Subunit; Lymphocyte Function-Associated Antigen 1; Macrophage Antigen 1

Integrin Beta 2 (CD18)
CCC B586
HGNC 6155
MGI 96611
PubMed 10438935
RGD 1305581
UniProt P05107
Wiki CD18

The ITGB2 is a protein belongs to the integrin beta chain family of proteins. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. This gene encodes the integrin beta chain beta 2. A given chain may combine with multiple partners resulting in different integrins. For example, beta 2 combines with the alpha L chain to form the integrin LFA-1, and combines with the alpha M chain to form the integrin Mac-1.

Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Defects in this gene are the cause of leukocyte adhesion deficiency type I (LAD1). Two transcript variants encoding the same protein have been identified for this gene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB586Hu01 Recombinant Integrin Beta 2 (CD18) Positive Control; Immunogen; SDS-PAGE; WB.
RPB586Hu02 Recombinant Integrin Beta 2 (CD18) Positive Control; Immunogen; SDS-PAGE; WB.
RPB586Hu03 Recombinant Integrin Beta 2 (CD18) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB586Hu01 Polyclonal Antibody to Integrin Beta 2 (CD18) WB; IHC; ICC; IP.
MAB586Hu21 Monoclonal Antibody to Integrin Beta 2 (CD18) WB; IHC; ICC; IP.
PAB586Hu02 Polyclonal Antibody to Integrin Beta 2 (CD18) WB; IHC; ICC; IP.
Assay Kits SEB586Hu ELISA Kit for Integrin Beta 2 (CD18) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB586Mu01 Recombinant Integrin Beta 2 (CD18) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB586Mu01 Polyclonal Antibody to Integrin Beta 2 (CD18) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Integrin Beta 2 (CD18) CLIA Kit Customized Service Offer
n/a ELISA Kit for Integrin Beta 2 (CD18) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB586Ra01 Recombinant Integrin Beta 2 (CD18) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB586Ra01 Polyclonal Antibody to Integrin Beta 2 (CD18) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Integrin Beta 2 (CD18) CLIA Kit Customized Service Offer
n/a ELISA Kit for Integrin Beta 2 (CD18) ELISA Kit Customized Service Offer
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  25. "Characterization of 11 new cases of leukocyte adhesion deficiency type 1 with seven novel mutations in the ITGB2 gene."J. Clin. Immunol. 30:756-760(2010) [PubMed] [Europe PMC] [Abstract]