≡

Cluster Of Differentiation 2 (CD2)

[Edit]

LFA2; SRBC; T11; T-Cell Surface Antigen T11/Leu-5; LFA-3 Receptor; Lymphocyte Function Associated Antigen 2; Erythrocyte Receptor; Rosette Receptor; Sheep Red Blood Cell Receptor

Cluster Of Differentiation 2 (CD2)
CCC B576
HGNC 1639
MGI 88320
PubMed 11739187
RGD 2297
UniProt P06729
Wiki CD2

CD2 (cluster of differentiation 2) is a cell adhesion molecule found on the surface of T cells and natural killer (NK) cells. It has also been called T-cell surface antigen T11/Leu-5, LFA-2, LFA-3 receptor, erythrocyte receptor and rosette receptor.

It interacts with other adhesion molecules, such as lymphocyte function-associated antigen-3 (LFA-3/CD58) in humans, or CD48 in rodents, which are expressed on the surfaces of other cells. In addition to its adhesive properties, CD2 also acts as a co-stimulatory molecule on T and NK cells.

Due to its structural characteristics, CD2 is a member of the immunoglobulin superfamily; it possesses two immunoglobulin-like domains in its extracellular portion.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins EPB576Hu61 Eukaryotic Cluster Of Differentiation 2 (CD2) Positive Control; Immunogen; SDS-PAGE; WB.
RPB576Hu01 Recombinant Cluster Of Differentiation 2 (CD2) Positive Control; Immunogen; SDS-PAGE; WB.
APB576Hu61 Active Cluster Of Differentiation 2 (CD2) Cell culture; Activity Assays.
Antibodies n/a Monoclonal Antibody to Cluster Of Differentiation 2 (CD2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cluster Of Differentiation 2 (CD2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cluster Of Differentiation 2 (CD2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cluster Of Differentiation 2 (CD2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB576Mu01 Recombinant Cluster Of Differentiation 2 (CD2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB576Mu01 Polyclonal Antibody to Cluster Of Differentiation 2 (CD2) WB; IHC; ICC; IP.
LAB576Mu71 Biotin-Linked Polyclonal Antibody to Cluster Of Differentiation 2 (CD2) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Cluster Of Differentiation 2 (CD2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cluster Of Differentiation 2 (CD2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB576Ra01 Recombinant Cluster Of Differentiation 2 (CD2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB576Ra01 Polyclonal Antibody to Cluster Of Differentiation 2 (CD2) WB; IHC; ICC; IP.
LAB576Ra71 Biotin-Linked Polyclonal Antibody to Cluster Of Differentiation 2 (CD2) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Cluster Of Differentiation 2 (CD2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cluster Of Differentiation 2 (CD2) ELISA Kit Customized Service Offer
  1. "Exon-intron organization and sequence comparison of human and murine T11 (CD2) genes."Proc. Natl. Acad. Sci. U.S.A. 85:1615-1619(1988) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular cloning of the CD2 antigen, the T-cell erythrocyte receptor, by a rapid immunoselection procedure."Proc. Natl. Acad. Sci. U.S.A. 84:3365-3369(1987) [PubMed] [Europe PMC] [Abstract]
  3. "Molecular cloning of the human T-lymphocyte surface CD2 (T11) antigen."Proc. Natl. Acad. Sci. U.S.A. 83:8718-8722(1986) [PubMed] [Europe PMC] [Abstract]
  4. ErratumProc. Natl. Acad. Sci. U.S.A. 84:7256-7256(1987)
  5. "Molecular cloning and expression of T11 cDNAs reveal a receptor-like structure on human T lymphocytes."Proc. Natl. Acad. Sci. U.S.A. 84:2941-2945(1987) [PubMed] [Europe PMC] [Abstract]
  6. "The structure of the human CD2 gene and its expression in transgenic mice."EMBO J. 7:1675-1682(1988) [PubMed] [Europe PMC] [Abstract]
  7. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Monoclonal antibody and ligand binding sites of the T cell erythrocyte receptor (CD2)."Nature 329:842-846(1987) [PubMed] [Europe PMC] [Abstract]
  10. "Overlapping but nonidentical binding sites on CD2 for CD58 and a second ligand CD59."Science 256:1805-1807(1992) [PubMed] [Europe PMC] [Abstract]
  11. "A cdc15-like adaptor protein (CD2BP1) interacts with the CD2 cytoplasmic domain and regulates CD2-triggered adhesion."EMBO J. 17:7320-7336(1998) [PubMed] [Europe PMC] [Abstract]
  12. "Crystal structure of the extracellular region of the human cell adhesion molecule CD2 at 2.5-A resolution."Structure 2:755-766(1994) [PubMed] [Europe PMC] [Abstract]
  13. "Structure of the glycosylated adhesion domain of human T lymphocyte glycoprotein CD2."Structure 1:69-81(1993) [PubMed] [Europe PMC] [Abstract]
  14. "Conformation and function of the N-linked glycan in the adhesion domain of human CD2."Science 269:1273-1278(1995) [PubMed] [Europe PMC] [Abstract]
  15. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]