Signaling Lymphocytic Activation Molecule Family, Member 1 (SLAMF1)

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CD150; SLAMF1; CDw150; SLAM; Signaling lymphocytic activation molecule

Signaling Lymphocytic Activation Molecule Family, Member 1 (SLAMF1)
  • Tatsuo et al. (2000) found that in MV-resistant cell lines infection with clinical MV and expression of SLAM, but not CD46, caused cytopathic effects (CPE). Likewise, anti-SLAM antibody protected cells from CPE when challenged with MV. Lymphoid cell lines expressing SLAM, but not lymphoid and myelomonocytic cell lines devoid of SLAM, were shown to be susceptible to MV. Tatsuo et al. (2000) noted that the expression of SLAM on activated B and T lymphocytes correlates with the pathology of MV infection in humans and monkeys, in which lymphoid organs are the chief sites of MV replication. They proposed that binding of MV to SLAM may impair the signaling functions of SLAM in lymphocyte activation and inhibit Th0/Th1 cytokine production, thereby promoting Th2 cytokine production.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB546Hu01 Recombinant Signaling Lymphocytic Activation Molecule Family, Member 1 (SLAMF1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB546Hu01 Polyclonal Antibody to Signaling Lymphocytic Activation Molecule Family, Member 1 (SLAMF1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Signaling Lymphocytic Activation Molecule Family, Member 1 (SLAMF1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Signaling Lymphocytic Activation Molecule Family, Member 1 (SLAMF1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Signaling Lymphocytic Activation Molecule Family, Member 1 (SLAMF1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Signaling Lymphocytic Activation Molecule Family, Member 1 (SLAMF1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Signaling Lymphocytic Activation Molecule Family, Member 1 (SLAMF1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Signaling Lymphocytic Activation Molecule Family, Member 1 (SLAMF1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Signaling Lymphocytic Activation Molecule Family, Member 1 (SLAMF1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB546Ra01 Recombinant Signaling Lymphocytic Activation Molecule Family, Member 1 (SLAMF1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB546Ra01 Polyclonal Antibody to Signaling Lymphocytic Activation Molecule Family, Member 1 (SLAMF1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Signaling Lymphocytic Activation Molecule Family, Member 1 (SLAMF1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Signaling Lymphocytic Activation Molecule Family, Member 1 (SLAMF1) ELISA Kit Customized Service Offer
  1. "A novel receptor involved in T-cell activation."Nature 376:260-263(1995) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Absence of SLAM mutations in EBV-associated lymphoproliferative disease patients."J. Med. Virol. 70:131-136(2003) [PubMed] [Europe PMC] [Abstract]
  5. "CDw150 associates with src-homology 2-containing inositol phosphatase and modulates CD95-mediated apoptosis."J. Immunol. 162:5719-5727(1999) [PubMed] [Europe PMC] [Abstract]
  6. "SLAM (CDw150) is a cellular receptor for measles virus."Nature 406:893-897(2000) [PubMed] [Europe PMC] [Abstract]
  7. "The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM."Nature 395:462-469(1998) [PubMed] [Europe PMC] [Abstract]
  8. "Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells."EMBO J. 20:5840-5852(2001) [PubMed] [Europe PMC] [Abstract]
  9. "A 'three-pronged' binding mechanism for the SAP/SH2D1A SH2 domain: structural basis and relevance to the XLP syndrome."EMBO J. 21:314-323(2002) [PubMed] [Europe PMC] [Abstract]
  10. "SAP couples Fyn to SLAM immune receptors."Nat. Cell Biol. 5:155-160(2003) [PubMed] [Europe PMC] [Abstract]
  11. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]