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Protein Disulfide Isomerase (PDI)

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PDI-A2; PDA2, PDIA2, PDIR; PDIP; Protein Disulfide Isomerase,Pancreatic; Protein Disulfide Isomerase-Associated 2; Pancreas-specific protein disulfide isomerase

Protein Disulfide Isomerase (PDI)
CCC B498
HGNC 14180
MGI 1916441
PubMed 23167757
RGD 1305164
UniProt Q13087

Protein disulfide isomerase or PDI is an enzyme in the endoplasmic reticulum in eukaryotes that catalyzes the formation and breakage of disulfide bonds between cysteine residues within proteins as they fold. Protein disulfide isomerases (EC 5.3.4.1), such as PDIP, are endoplasmic reticulum (ER) resident proteins that catalyze protein folding and thiol-disulfide interchange reactions. Desilva et al. (1996) cloned PDIP from an insulinoma subtraction cDNA library. The deduced 511-amino acid protein has a calculated molecular mass of about 56.6 kD and contains 2 thioredoxin-like catalytic sites, a C-terminal ER retention sequence (KEEL), and 3 potential N-glycosylation sites. PDIP shares about 46% identity with bovine, mouse, rabbit, and human PDIs . Northern blot analysis detected a 2.0-kb transcript expressed exclusively in pancreas.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB498Hu01 Recombinant Protein Disulfide Isomerase (PDI) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB498Hu01 Polyclonal Antibody to Protein Disulfide Isomerase (PDI) WB; IHC; ICC; IP.
MAB498Hu22 Monoclonal Antibody to Protein Disulfide Isomerase (PDI) WB; IHC; ICC; IP.
PAB498Hu02 Polyclonal Antibody to Protein Disulfide Isomerase (PDI) WB; IHC; ICC; IP.
Assay Kits SEB498Hu ELISA Kit for Protein Disulfide Isomerase (PDI) Enzyme-linked immunosorbent assay for Antigen Detection.
SCB498Hu CLIA Kit for Protein Disulfide Isomerase (PDI) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB498Mu01 Recombinant Protein Disulfide Isomerase (PDI) Positive Control; Immunogen; SDS-PAGE; WB.
RPB498Mu02 Recombinant Protein Disulfide Isomerase (PDI) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB498Mu01 Polyclonal Antibody to Protein Disulfide Isomerase (PDI) WB; IHC; ICC; IP.
PAB498Mu02 Polyclonal Antibody to Protein Disulfide Isomerase (PDI) WB; IHC; ICC; IP.
Assay Kits SEB498Mu ELISA Kit for Protein Disulfide Isomerase (PDI) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Disulfide Isomerase (PDI) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Disulfide Isomerase (PDI) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Disulfide Isomerase (PDI) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Disulfide Isomerase (PDI) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Disulfide Isomerase (PDI) ELISA Kit Customized Service Offer
  1. "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16."Hum. Mol. Genet. 10:339-352(2001) [PubMed] [Europe PMC] [Abstract]
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  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Characterization and chromosomal localization of a new protein disulfide isomerase, PDIp, highly expressed in human pancreas."DNA Cell Biol. 15:9-16(1996) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Molecular characterization of a pancreas-specific protein disulfide isomerase, PDIp."DNA Cell Biol. 16:269-274(1997) [PubMed] [Europe PMC] [Abstract]
  7. "A subset of chaperones and folding enzymes form multiprotein complexes in endoplasmic reticulum to bind nascent proteins."Mol. Biol. Cell 13:4456-4469(2002) [PubMed] [Europe PMC] [Abstract]
  8. "Human pancreas-specific protein disulfide isomerase homolog (PDIp) is redox-regulated through formation of an inter-subunit disulfide bond."Arch. Biochem. Biophys. 485:1-9(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Human pancreas-specific protein disulfide isomerase homolog (PDIp) is an intracellular estrogen-binding protein that modulates estrogen levels and actions in target cells."J. Steroid Biochem. Mol. Biol. 115:20-29(2009) [PubMed] [Europe PMC] [Abstract]
  10. "N-linked glycosylation modulates dimerization of protein disulfide isomerase family A member 2 (PDIA2)."FEBS J. 280:233-243(2013) [PubMed] [Europe PMC] [Abstract]