N-cadherin (NCAD)

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CDw325; CD325; CDHN; CDH2; Cadherin 2 Type 1; N-Cadherin

N-cadherin (NCAD)

Cadherin 2, type 1, N-cadherin (neuronal),  is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprising five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. The protein functions during gastrulation and is required for establishment of left-right asymmetry. At certain central nervous system synapses, presynaptic to postsynaptic adhesion is mediated at least in part by this gene product. Reid and Hemperly (1990) obtained a full-length NCAD clone from a Kelly neuroblastoma library. The NCAD gene encodes a 907-amino acid protein that includes a 159-amino acid signal sequence. Human and mouse nucleotide sequences are 96% identical.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB481Hu01 Recombinant N-cadherin (NCAD) Positive Control; Immunogen; SDS-PAGE; WB.
RPB481Hu02 Recombinant N-cadherin (NCAD) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB481Hu01 Polyclonal Antibody to N-cadherin (NCAD) WB; IHC; ICC; IP.
MAB481Hu22 Monoclonal Antibody to N-cadherin (NCAD) WB; IHC; ICC; IP.
PAB481Hu02 Polyclonal Antibody to N-cadherin (NCAD) WB; IHC; ICC; IP.
LAB481Hu71 Biotin-Linked Polyclonal Antibody to N-cadherin (NCAD) WB; IHC; ICC.
Assay Kits SEB481Hu ELISA Kit for N-cadherin (NCAD) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB481Mu01 Recombinant N-cadherin (NCAD) Positive Control; Immunogen; SDS-PAGE; WB.
RPB481Mu02 Recombinant N-cadherin (NCAD) Positive Control; Immunogen; SDS-PAGE; WB.
RPB481Mu03 Recombinant N-cadherin (NCAD) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB481Mu01 Polyclonal Antibody to N-cadherin (NCAD) WB; IHC; ICC; IP.
PAB481Mu02 Polyclonal Antibody to N-cadherin (NCAD) WB; IHC; ICC; IP.
PAB481Mu03 Polyclonal Antibody to N-cadherin (NCAD) WB; IHC; ICC; IP.
LAB481Mu71 Biotin-Linked Polyclonal Antibody to N-cadherin (NCAD) WB; IHC; ICC.
Assay Kits SEB481Mu ELISA Kit for N-cadherin (NCAD) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB481Ra01 Recombinant N-cadherin (NCAD) Positive Control; Immunogen; SDS-PAGE; WB.
RPB481Ra02 Recombinant N-cadherin (NCAD) Positive Control; Immunogen; SDS-PAGE; WB.
RPB481Ra03 Recombinant N-cadherin (NCAD) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB481Ra01 Polyclonal Antibody to N-cadherin (NCAD) WB; IHC; ICC; IP.
PAB481Ra02 Polyclonal Antibody to N-cadherin (NCAD) WB; IHC; ICC; IP.
PAB481Ra03 Polyclonal Antibody to N-cadherin (NCAD) WB; IHC; ICC; IP.
LAB481Ra71 Biotin-Linked Polyclonal Antibody to N-cadherin (NCAD) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for N-cadherin (NCAD) CLIA Kit Customized Service Offer
n/a ELISA Kit for N-cadherin (NCAD) ELISA Kit Customized Service Offer
  1. "Human N-cadherin: nucleotide and deduced amino acid sequence."Nucleic Acids Res. 18:5896-5896(1990) [PubMed] [Europe PMC] [Abstract]
  2. "Extrajunctional distribution of N-cadherin in cultured human endothelial cells."J. Cell Sci. 102:7-17(1992) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "DNA sequence and analysis of human chromosome 18." Nature 437:551-555(2005) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "N-cadherin gene maps to human chromosome 18 and is not linked to the E-cadherin gene."J. Neurochem. 55:805-812(1990) [PubMed] [Europe PMC] [Abstract]
  7. "Structure of the human N-cadherin gene: YAC analysis and fine chromosomal mapping to 18q11.2."Genomics 22:172-179(1994) [PubMed] [Europe PMC] [Abstract]
  8. "Adhesion signaling by a novel mitotic substrate of src kinases."Oncogene 24:5333-5343(2005) [PubMed] [Europe PMC] [Abstract]
  9. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]