Azurocidin (AZU)

[Edit]

AZAMP; AZU1; HBP; HUMAZUR; NAZC; CAP37; Cationic Antimicrobial Protein 37; Heparin-Binding Protein; Neutrophil Azurocidin

Azurocidin (AZU)

Azurophil granules, specialized lysosomes of the neutrophil, contain at least 10 proteins implicated in the killing of microorganisms. Azurocidin is an azurophil granule antibiotic protein, with monocyte chemotactic and antibacterial activity. It is also an important multifunctional inflammatory mediator.

Azurocidin 1 is a member of the serine protease gene family but it is not a serine proteinase, because the active site serine and histidine residues are replaced. The genes encoding this protein, neutrophil elastase 2, and proteinase 3 are in a cluster located at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB461Hu01 Recombinant Azurocidin (AZU) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB461Hu01 Polyclonal Antibody to Azurocidin (AZU) WB,IHC
MAB461Hu22 Monoclonal Antibody to Azurocidin (AZU) WB
LAB461Hu71 Biotin-Linked Polyclonal Antibody to Azurocidin (AZU) WB; IHC; ICC.
MAB461Hu21 Monoclonal Antibody to Azurocidin (AZU) IHC
MAB461Hu23 Monoclonal Antibody to Azurocidin (AZU) WB; IHC; ICC; IP.
MAB461Hu24 Monoclonal Antibody to Azurocidin (AZU) WB.
MAB461Hu25 Monoclonal Antibody to Azurocidin (AZU) WB; IHC; ICC; IP.
MAB461Hu27 Monoclonal Antibody to Azurocidin (AZU) WB; IHC; ICC; IP.
Assay Kits SEB461Hu ELISA Kit for Azurocidin (AZU) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Cloning of the cDNA for the serine protease homolog CAP37/azurocidin, a microbicidal and chemotactic protein from human granulocytes."J. Immunol. 147:3210-3214(1991) [PubMed] [Europe PMC] [Abstract]
  2. "Three human elastase-like genes coordinately expressed in the myelomonocyte lineage are organized as a single genetic locus on 19pter."Proc. Natl. Acad. Sci. U.S.A. 89:8215-8219(1992) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Complementary DNA sequence of human neutrophil azurocidin, an antibiotic with extensive homology to serine proteases."Biochem. Biophys. Res. Commun. 177:688-695(1991) [PubMed] [Europe PMC] [Abstract]
  6. "Amino acid sequence of CAP37, a human neutrophil granule-derived antibacterial and monocyte-specific chemotactic glycoprotein structurally similar to neutrophil elastase."FEBS Lett. 272:200-204(1990) [PubMed] [Europe PMC] [Abstract]
  7. "Covalent structure of two novel neutrophile leucocyte-derived proteins of porcine and human origin. Neutrophile elastase homologues with strong monocyte and fibroblast chemotactic activities."Eur. J. Biochem. 197:535-547(1991) [PubMed] [Europe PMC] [Abstract]
  8. "CAP37, a human neutrophil-derived chemotactic factor with monocyte specific activity."J. Clin. Invest. 85:1468-1476(1990) [PubMed] [Europe PMC] [Abstract]
  9. "CAP 37, a 37 kD human neutrophil granule cationic protein shares homology with inflammatory proteinases."Life Sci. 46:189-196(1990) [PubMed] [Europe PMC] [Abstract]
  10. "Comparison of granule proteins from human polymorphonuclear leukocytes which are bactericidal toward Pseudomonas aeruginosa."Infect. Immun. 59:4193-4200(1991) [PubMed] [Europe PMC] [Abstract]
  11. "PMN elastases: a comparison of the specificity of human isozymes and the enzyme from other species toward substrates and inhibitors."Arch. Biochem. Biophys. 286:284-292(1991) [PubMed] [Europe PMC] [Abstract]
  12. "Antibiotic proteins of human polymorphonuclear leukocytes."Proc. Natl. Acad. Sci. U.S.A. 86:5610-5614(1989) [PubMed] [Europe PMC] [Abstract]
  13. "Characterization of two azurphil granule proteases with active-site homology to neutrophil elastase."J. Biol. Chem. 265:2038-2041(1990) [PubMed] [Europe PMC] [Abstract]
  14. "Human neutrophil azurocidin synergizes with leukocyte elastase and cathepsin G in the killing of Capnocytophaga sputigena."Infect. Immun. 60:4973-4975(1992) [PubMed] [Europe PMC] [Abstract]
  15. "Human neutrophil granule cationic protein CAP37 is a specific macrophage chemotaxin that shares homology with inflammatory proteinases."Adv. Exp. Med. Biol. 305:89-96(1991) [PubMed] [Europe PMC] [Abstract]
  16. "Synthetic bactericidal peptide based on CAP37: a 37-kDa human neutrophil granule-associated cationic antimicrobial protein chemotactic for monocytes."Proc. Natl. Acad. Sci. U.S.A. 90:4733-4737(1993) [PubMed] [Europe PMC] [Abstract]
  17. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  18. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  19. "Structure of HBP, a multifunctional protein with a serine proteinase fold."Nat. Struct. Biol. 4:265-268(1997) [PubMed] [Europe PMC] [Abstract]
  20. "Atomic resolution structure of human HBP/CAP37/azurocidin."Acta Crystallogr. D 54:598-609(1998) [PubMed] [Europe PMC] [Abstract]