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Early Growth Response Protein 2 (EGR2)

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CMT1D; CMT4E; KROX20; Krox-20 Homolog,Drosophil; E3 SUMO-protein ligase EGR2; Zinc finger protein Krox-20

Early Growth Response Protein 2 (EGR2)
CCC B451
HGNC 3239
MGI 95296
PubMed 11394999
RGD 621608
UniProt P11161
Wiki EGR2

  • The early growth response protein 2 is a transcription factor with three tandem C2H2-type zinc fingers. Mutations in this gene are associated with the autosomal dominant Charcot-Marie-Tooth disease, type 1. Using microarray expression profiling, Nagarajan et al. identified 98 known genes that were induced by Egr2 in Schwann cells. The putative Egr2 target genes included myelin proteins and enzymes required for synthesis of normal myelin lipids. Using RT-PCR to monitor Schwann cell gene expression, Nagarajan et al. confirmed that Egr2 is sufficient for induction of target genes including MPZ , PMP22 , MBP , MAG , CX32 , and periaxin. Using EGR2 DNA-binding domain mutants, Nagarajan et al.  demonstrated a dominant-negative inhibition of wildtype Egr2-mediated induction of essential myelin genes.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB451Hu01 Recombinant Early Growth Response Protein 2 (EGR2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB451Hu01 Polyclonal Antibody to Early Growth Response Protein 2 (EGR2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Early Growth Response Protein 2 (EGR2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Early Growth Response Protein 2 (EGR2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB451Mu01 Recombinant Early Growth Response Protein 2 (EGR2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB451Mu01 Polyclonal Antibody to Early Growth Response Protein 2 (EGR2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Early Growth Response Protein 2 (EGR2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Early Growth Response Protein 2 (EGR2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Early Growth Response Protein 2 (EGR2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Early Growth Response Protein 2 (EGR2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Early Growth Response Protein 2 (EGR2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Early Growth Response Protein 2 (EGR2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Early Growth Response Protein 2 (EGR2) ELISA Kit Customized Service Offer
  1. "Molecular cloning, sequencing, and mapping of EGR2, a human early growth response gene encoding a protein with 'zinc-binding finger' structure."Proc. Natl. Acad. Sci. U.S.A. 85:7164-7168(1988) [PubMed] [Europe PMC] [Abstract]
  2. ErratumProc. Natl. Acad. Sci. U.S.A. 86:515-515(1989)
  3. "Mutations in the early growth response 2 (EGR2) gene are associated with hereditary myelinopathies."Nat. Genet. 18:382-384(1998) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  6. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "The serum and TPA responsive promoter and intron-exon structure of EGR2, a human early growth response gene encoding a zinc finger protein."Nucleic Acids Res. 18:2749-2757(1990) [PubMed] [Europe PMC] [Abstract]
  9. "HCF-1 functions as a coactivator for the zinc finger protein Krox20."J. Biol. Chem. 278:51116-51124(2003) [PubMed] [Europe PMC] [Abstract]
  10. "The HECT-type E3 ubiquitin ligase AIP2 inhibits activation-induced T-cell death by catalyzing EGR2 ubiquitination."Mol. Cell. Biol. 29:5348-5356(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  12. "The transcription factor Krox20 is an E3 ligase that sumoylates its Nab coregulators."EMBO Rep. 12:1018-1023(2011) [PubMed] [Europe PMC] [Abstract]
  13. "Homozygous deletion of an EGR2 enhancer in congenital amyelinating neuropathy."Ann. Neurol. 71:719-723(2012) [PubMed] [Europe PMC] [Abstract]
  14. "EGR2 gene mutation in a patient affected with Charcot-Marie-Tooth type 1."Eur. J. Hum. Genet. Suppl. 7:99-99(1999)
  15. "A novel mutation (D305V) in the early growth response 2 gene is associated with severe Charcot-Marie-Tooth type 1 disease."Hum. Mutat. 14:353-354(1999) [PubMed] [Europe PMC] [Abstract]
  16. "Novel missense mutation in the early growth response 2 gene associated with Dejerine-Sottas syndrome phenotype."Neurology 52:1827-1832(1999) [PubMed] [Europe PMC] [Abstract]
  17. "Cranial nerve involvement in CMT disease type 1 due to early growth response 2 gene mutation."Neurology 54:1696-1698(2000) [PubMed] [Europe PMC] [Abstract]
  18. "A novel missense mutation in the early growth response 2 gene associated with late-onset Charcot-Marie-Tooth disease type 1."J. Neurol. Sci. 184:149-153(2001) [PubMed] [Europe PMC] [Abstract]
  19. "Screening of the early growth response 2 gene in Japanese patients with Charcot-Marie-Tooth disease type 1."J. Neurol. Sci. 210:61-64(2003) [PubMed] [Europe PMC] [Abstract]
  20. "Mutational analysis of PMP22, MPZ, GJB1, EGR2 and NEFL in Korean Charcot-Marie-Tooth neuropathy patients."Hum. Mutat. 24:185-186(2004) [PubMed] [Europe PMC] [Abstract]
  21. "Two missense mutations of EGR2 R359W and GJB1 V136A in a Charcot-Marie-Tooth disease family."Neurogenetics 6:159-163(2005) [PubMed] [Europe PMC] [Abstract]