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Immunoglobulin Superfamily, Member 2 (IGSF2)

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CD101; V7; EWI-101; Cell surface glycoprotein V7; Glu-Trp-Ile EWI motif-containing protein 101

Immunoglobulin Superfamily, Member 2 (IGSF2)
CCC B432
HGNC 5949
MGI 2685862
PubMed 9389317
UniProt Q93033
Wiki IGSF2

Sequence analysis predicted that the 1,021-amino acid IGSF2 is a type I integral transmembrane protein that has a 20-amino acid hydrophobic signal sequence, a 934-amino acid extracellular domain, a 25-amino acid transmembrane domain, and a short, highly charged 42-amino acid cytoplasmic domain.

The extracellular portion contains 7 pairs of regularly spaced cysteine residues suggestive of a variable type Ig-like protein. Northern blot analysis revealed strong expression of a 3.6-kb transcript in monocytes, peripheral blood lymphocytes, and lung, and weaker expression in spleen, thymus, and small intestine. An additional minor transcript of 6.4 kb, which may represent an incompletely spliced transcript, was also seen.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB432Hu01 Recombinant Immunoglobulin Superfamily, Member 2 (IGSF2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB432Hu01 Polyclonal Antibody to Immunoglobulin Superfamily, Member 2 (IGSF2) WB; IHC
Assay Kits n/a CLIA Kit for Immunoglobulin Superfamily, Member 2 (IGSF2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Immunoglobulin Superfamily, Member 2 (IGSF2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB432Mu01 Recombinant Immunoglobulin Superfamily, Member 2 (IGSF2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB432Mu01 Polyclonal Antibody to Immunoglobulin Superfamily, Member 2 (IGSF2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Immunoglobulin Superfamily, Member 2 (IGSF2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Immunoglobulin Superfamily, Member 2 (IGSF2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB432Ra01 Recombinant Immunoglobulin Superfamily, Member 2 (IGSF2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB432Ra01 Polyclonal Antibody to Immunoglobulin Superfamily, Member 2 (IGSF2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Immunoglobulin Superfamily, Member 2 (IGSF2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Immunoglobulin Superfamily, Member 2 (IGSF2) ELISA Kit Customized Service Offer
  1. "V7, a novel leukocyte surface protein that participates in T cell activation. II. Molecular cloning and characterization of the V7 gene."J. Immunol. 154:4434-4443(1995) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  3. "V7, a novel leukocyte surface protein that participates in T cell activation. I. Tissue distribution and functional studies."J. Immunol. 154:4423-4433(1995) [PubMed] [Europe PMC] [Abstract]
  4. "Ligation of the V7 molecule on T cells blocks anergy induction through a CD28-independent mechanism."J. Immunol. 159:1115-1124(1997) [PubMed] [Europe PMC] [Abstract]
  5. "CD101 is expressed by skin dendritic cells. Role in T-lymphocyte activation."Tissue Antigens 50:439-448(1997) [PubMed] [Europe PMC] [Abstract]
  6. "V7 (CD101) ligation inhibits TCR/CD3-induced IL-2 production by blocking Ca2+ flux and nuclear factor of activated T cell nuclear translocation."J. Immunol. 161:209-217(1998) [PubMed] [Europe PMC] [Abstract]
  7. "Triggering CD101 molecule on human cutaneous dendritic cells inhibits T cell proliferation via IL-10 production."Eur. J. Immunol. 30:3132-3139(2000) [PubMed] [Europe PMC] [Abstract]
  8. "CD101 expression by Langerhans cell histiocytosis cells."Histopathology 36:229-232(2000) [PubMed] [Europe PMC] [Abstract]
  9. "EWI-2 is a major CD9 and CD81 partner and member of a novel Ig protein subfamily."J. Biol. Chem. 276:40545-40554(2001) [PubMed] [Europe PMC] [Abstract]
  10. "CD4+ CD56+ blastic tumor cells express CD101 molecules."J. Invest. Dermatol. 124:668-669(2005) [PubMed] [Europe PMC] [Abstract]