≡

Ephrin Type A Receptor 1 (EPHA1)

[Edit]

EPH; EPHT; EPHT1; EPH Receptor A1; EPH tyrosine kinase 1; Erythropoietin-producing hepatoma receptor; Tyrosine-protein kinase receptor EPH

Ephrin Type A Receptor 1 (EPHA1)
CCC B368
HGNC 3385
MGI 107381
PubMed 18802966
RGD 1304680
UniProt P21709
Wiki EPHA1

Ephrin type-A receptor 1 is a protein  belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats.

The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene is expressed in some human cancer cell lines and has been implicated in carcinogenesis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB368Hu01 Recombinant Ephrin Type A Receptor 1 (EPHA1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB368Hu01 Polyclonal Antibody to Ephrin Type A Receptor 1 (EPHA1) WB; IHC; ICC/IF
MAB368Hu22 Monoclonal Antibody to Ephrin Type A Receptor 1 (EPHA1) WB; IHC; ICC; IP.
Assay Kits SEB368Hu ELISA Kit for Ephrin Type A Receptor 1 (EPHA1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB368Mu01 Recombinant Ephrin Type A Receptor 1 (EPHA1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB368Mu01 Polyclonal Antibody to Ephrin Type A Receptor 1 (EPHA1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Ephrin Type A Receptor 1 (EPHA1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ephrin Type A Receptor 1 (EPHA1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ephrin Type A Receptor 1 (EPHA1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ephrin Type A Receptor 1 (EPHA1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ephrin Type A Receptor 1 (EPHA1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ephrin Type A Receptor 1 (EPHA1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ephrin Type A Receptor 1 (EPHA1) ELISA Kit Customized Service Offer

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ephrin Type A Receptor 1 (EPHA1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ephrin Type A Receptor 1 (EPHA1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ephrin Type A Receptor 1 (EPHA1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ephrin Type A Receptor 1 (EPHA1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ephrin Type A Receptor 1 (EPHA1) ELISA Kit Customized Service Offer
  1. "A novel putative tyrosine kinase receptor encoded by the eph gene."Science 238:1717-1720(1987) [PubMed] [Europe PMC] [Abstract]
  2. "Genomic structure of the EPHA1 receptor tyrosine kinase gene."Mol. Cell. Probes 13:169-173(1999) [PubMed] [Europe PMC] [Abstract]
  3. "Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis."Arthritis Res. Ther. 10:R73-R73(2008) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
  5. "Human chromosome 7: DNA sequence and biology." Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Unified nomenclature for Eph family receptors and their ligands, the ephrins."Cell 90:403-404(1997) [PubMed] [Europe PMC] [Abstract]
  8. "Ephrin-A1 stimulates migration of CD8+CCR7+ T lymphocytes."Eur. J. Immunol. 37:2326-2336(2007) [PubMed] [Europe PMC] [Abstract]
  9. "EphA1 interacts with integrin-linked kinase and regulates cell morphology and motility."J. Cell Sci. 122:243-255(2009) [PubMed] [Europe PMC] [Abstract]
  10. "EphA1 receptor silencing by small interfering RNA has antiangiogenic and antitumor efficacy in hepatocellular carcinoma."Oncol. Rep. 23:563-570(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Development and validation of a method for profiling post-translational modification activities using protein microarrays."PLoS ONE 5:E11332-E11332(2010) [PubMed] [Europe PMC] [Abstract]
  12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  13. "Spatial structure and pH-dependent conformational diversity of dimeric transmembrane domain of the receptor tyrosine kinase EphA1."J. Biol. Chem. 283:29385-29395(2008) [PubMed] [Europe PMC] [Abstract]
  14. "Sam domain of human ephrin type-a receptor 1 (epha1)."Submitted (JUN-2009) to the PDB data bank
  15. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
  16. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]