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Glucokinase Regulatory Protein (GKRP)

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GCKR; Glucokinase(hexokinase 4)regulator

Glucokinase Regulatory Protein (GKRP)
CCC B365
HGNC 4196
MGI 1096345
PubMed 23733961
RGD 2671
UniProt Q14397
Wiki GKRP

The glucokinase regulatory protein (GKRP) is a protein produced in hepatocytes (liver cells). GKRP binds and moves glucokinase (GK), thereby controlling both activity and intracellular location of this key enzyme of glucose metabolism.GKRP is a 68 kD protein of 626 amino acids.

It is coded for by a 19 exon gene, GCKR, on the short arm of chromosome 2 (2p23). GKRP was discovered by Emile van Schaftingen and reported in 1989 Glucokinase (GK) in liver cells phosphorylates glucose, preparing it for incorporation into glycogen. During periods of ample glucose supply, most GK activity can be found in the peripheral cytoplasm where glycogen synthesis is occurring.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB365Hu01 Recombinant Glucokinase Regulatory Protein (GKRP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB365Hu01 Polyclonal Antibody to Glucokinase Regulatory Protein (GKRP) WB; IHC; ICC; IP.
LAB365Hu71 Biotin-Linked Polyclonal Antibody to Glucokinase Regulatory Protein (GKRP) WB; IHC; ICC.
LAB365Hu81 FITC-Linked Polyclonal Antibody to Glucokinase Regulatory Protein (GKRP) WB; IHC; ICC; IF.
Assay Kits n/a CLIA Kit for Glucokinase Regulatory Protein (GKRP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Glucokinase Regulatory Protein (GKRP) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB365Mu01 Recombinant Glucokinase Regulatory Protein (GKRP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB365Mu01 Polyclonal Antibody to Glucokinase Regulatory Protein (GKRP) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Glucokinase Regulatory Protein (GKRP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Glucokinase Regulatory Protein (GKRP) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB365Ra01 Recombinant Glucokinase Regulatory Protein (GKRP) Positive Control; Immunogen; SDS-PAGE; WB.
RPB365Ra02 Recombinant Glucokinase Regulatory Protein (GKRP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB365Ra02 Polyclonal Antibody to Glucokinase Regulatory Protein (GKRP) WB; IHC; ICC; IP.
MAB365Ra22 Monoclonal Antibody to Glucokinase Regulatory Protein (GKRP) WB; IHC; ICC; IP.
PAB365Ra01 Polyclonal Antibody to Glucokinase Regulatory Protein (GKRP) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Glucokinase Regulatory Protein (GKRP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Glucokinase Regulatory Protein (GKRP) ELISA Kit Customized Service Offer
  1. "Human glucokinase regulatory protein (GCKR): cDNA and genomic cloning, complete primary structure, and chromosomal localization."Mamm. Genome 6:532-536(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Organization of the human glucokinase regulator gene GCKR."Genomics 49:137-142(1998) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Glucokinase regulatory protein is essential for the proper subcellular localisation of liver glucokinase."FEBS Lett. 456:332-338(1999) [PubMed] [Europe PMC] [Abstract]
  7. "The common P446L polymorphism in GCKR inversely modulates fasting glucose and triglyceride levels and reduces type 2 diabetes risk in the DESIR prospective general French population."Diabetes 57:2253-2257(2008) [PubMed] [Europe PMC] [Abstract]
  8. "The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver."Hum. Mol. Genet. 18:4081-4088(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Molecular basis for the role of glucokinase regulatory protein as the allosteric switch for glucokinase."Proc. Natl. Acad. Sci. U.S.A. 110:10171-10176(2013) [PubMed] [Europe PMC] [Abstract]
  10. "Crystal structure of glucokinase regulatory protein."Biochemistry 52:3523-3531(2013) [PubMed] [Europe PMC] [Abstract]
  11. "Common missense variant in the glucokinase regulatory protein gene is associated with increased plasma triglyceride and C-reactive protein but lower fasting glucose concentrations." Diabetes 57:3112-3121(2008) [PubMed] [Europe PMC] [Abstract]