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15-Lipoxygenase-2 (15-LO-2)

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ALOX15B; LOX15B; 15-LOX-2; Arachidonate 15-lipoxygenase type II; Lipoxygenase 15, Type B; 15-lipoxygenase 2; Linoleate 13-lipoxygenase 15-LOb Arachidonate-15-Lipoxygenase, Type B

15-Lipoxygenase-2 (15-LO-2)
CCC B356
HGNC 434
MGI 1098228
PubMed 24373925
RGD 628809
UniProt O15296
Wiki ALOX15B

Arachidonate 15-lipoxygenase type II is a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. The encoded protein converts arachidonic acid exclusively to 15S-hydroperoxyeicosatetraenoic acid, while metabolizing linoleic acid less effectively.

When expressed in mammalian cells, ALOX15B converted arachidonic acid exclusively to 15S-hydroperoxide, while linoleic acid was a relatively poor substrate. Northern blot analysis detected expression of a 2.5- to 3-kb ALOX15B mRNA in lung, cornea, and prostate. The previously characterized ALOX15 has distinct catalytic activities and is strongly expressed in specific blood cell types.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB356Hu01 Recombinant 15-Lipoxygenase-2 (15-LO-2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAB356Hu21 Monoclonal Antibody to 15-Lipoxygenase-2 (15-LO-2) WB; IHC; ICC; IP.
PAB356Hu01 Polyclonal Antibody to 15-Lipoxygenase-2 (15-LO-2) WB; IHC; ICC; IP.
Assay Kits SEB356Hu ELISA Kit for 15-Lipoxygenase-2 (15-LO-2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant 15-Lipoxygenase-2 (15-LO-2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to 15-Lipoxygenase-2 (15-LO-2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to 15-Lipoxygenase-2 (15-LO-2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for 15-Lipoxygenase-2 (15-LO-2) CLIA Kit Customized Service Offer
n/a ELISA Kit for 15-Lipoxygenase-2 (15-LO-2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB356Ra01 Recombinant 15-Lipoxygenase-2 (15-LO-2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB356Ra01 Polyclonal Antibody to 15-Lipoxygenase-2 (15-LO-2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for 15-Lipoxygenase-2 (15-LO-2) CLIA Kit Customized Service Offer
n/a ELISA Kit for 15-Lipoxygenase-2 (15-LO-2) ELISA Kit Customized Service Offer
  1. "Discovery of a second 15S-lipoxygenase in humans."Proc. Natl. Acad. Sci. U.S.A. 94:6148-6152(1997) [PubMed] [Europe PMC] [Abstract]
  2. "A gene cluster encoding human epidermis-type lipoxygenases at chromosome 17p13.1: cloning, physical mapping, and expression."Genomics 73:323-330(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Evidence that arachidonate 15-lipoxygenase 2 is a negative cell cycle regulator in normal prostate epithelial cells."J. Biol. Chem. 277:16189-16201(2002) [PubMed] [Europe PMC] [Abstract]
  4. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Differential characteristics of human 15-lipoxygenase isozymes and a novel splice variant of 15S-lipoxygenase."Eur. J. Biochem. 266:83-93(1999) [PubMed] [Europe PMC] [Abstract]
  7. "Identification of amino acid determinants of the positional specificity of mouse 8S-lipoxygenase and human 15S-lipoxygenase-2."J. Biol. Chem. 275:1287-1293(2000) [PubMed] [Europe PMC] [Abstract]
  8. "Subcellular localization and tumor-suppressive functions of 15-lipoxygenase 2 (15-LOX2) and its splice variants."J. Biol. Chem. 278:25091-25100(2003) [PubMed] [Europe PMC] [Abstract]
  9. "Double dioxygenation by mouse 8S-lipoxygenase: specific formation of a potent peroxisome proliferator-activated receptor alpha agonist."Biochem. Biophys. Res. Commun. 338:136-143(2005) [PubMed] [Europe PMC] [Abstract]
  10. "15-Lipoxygenase-2 expression in human macrophages induces chemokine secretion and T cell migration."Atherosclerosis 199:34-40(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Reciprocal regulation of 12- and 15-lipoxygenases by UV-irradiation in human keratinocytes."FEBS Lett. 582:3249-3253(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Arachidonate 15-lipoxygenase type B knockdown leads to reduced lipid accumulation and inflammation in atherosclerosis."PLoS ONE 7:E43142-E43142(2012) [PubMed] [Europe PMC] [Abstract]
  13. "The structure of human 15-lipoxygenase-2 with a substrate mimic."J. Biol. Chem. 289:8562-8569(2014) [PubMed] [Europe PMC] [Abstract]