Caspase 13 (CASP13)


ERICE; Cysteinyl Aspartate Specific Proteinases 13; Evolutionarily Related Interleukin-1β Converting Enzyme; Apoptosis-Related Cysteine Peptidase

Caspase 13 (CASP13)
Caspase 13 is an enzyme known as a cysteine protease that was identified in cattle that is also called "Evolutionarily Related Interleukin-1β Converting Enzyme" (ERICE). It belongs to a family of enzymes called caspases that cleave their substrates at C-terminal aspartic acid residues. Although this enzyme was originally reported as a human caspase that could be activated by caspase 8, later studies confirmed the gene identified for caspase 13 came from bovine origin, and is the likely orthologue of human caspase 4. Caspases are are expressed as latent zymogens and are activated by an autoproteolytic mechanism or by processing by other proteases (frequently other caspases). Human caspases can be subdivided into three functional groups: cytokine activation (caspase-1, -4, -5, and -13), apoptosis initiation (caspase-2, -8, -9, -and -10), and apoptosis execution (caspase-3, -6, and -7).

Organism species: Bos taurus; Bovine (Cattle)

Proteins n/a Recombinant Caspase 13 (CASP13) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Caspase 13 (CASP13) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Caspase 13 (CASP13) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Caspase 13 (CASP13) CLIA Kit Customized Service Offer
n/a ELISA Kit for Caspase 13 (CASP13) ELISA Kit Customized Service Offer
  1. "ERICE, a novel FLICE-activatable caspase."J. Biol. Chem. 273:15702-15707(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Evidence that caspase-13 is not a human but a bovine gene."Biochem. Biophys. Res. Commun. 285:1150-1154(2001) [PubMed] [Europe PMC] [Abstract]