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Kruppel Like Factor 4, Gut (KLF4)

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EZF; GKLF; Gut-Enriched Krüppel-Like Factor; Epithelial zinc finger protein EZF

Kruppel Like Factor 4, Gut (KLF4)
CCC B241
HGNC 6348
MGI 1342287
PubMed 16244670
RGD 621445
UniProt O43474
Wiki KLF4

Krueppel-like factor 4  acts as a transcriptional activator or repressor depending on the promoter context and/or cooperation with other transcription factors. For example, Klf4 transactivates the iNOS promoter in cooperation with p65 (RelA), and the p21Cip1/Waf1 promoter in cooperation with p53, but it directly suppresses the p53 promoter and inhibits ornithine decarboxylase promoter activity by competing with specificity protein-1 (Sp-1). Klf4 also interacts with the p300/CBP transcription co-activators.KLF4 also contains a potential nuclear localization signal. The human KLF4 protein shares 91% sequence identity with mouse Ezf. Northern blot analysis detected a 3.5-kb KLF4 transcript in RNA from both human umbilical vein endothelial cells and human aortic endothelial cells.

 

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB241Hu01 Recombinant Kruppel Like Factor 4, Gut (KLF4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB241Hu01 Polyclonal Antibody to Kruppel Like Factor 4, Gut (KLF4) WB; IHC; ICC; IP.
MAB241Hu22 Monoclonal Antibody to Kruppel Like Factor 4, Gut (KLF4) WB; IHC; ICC; IP.
Assay Kits SEB241Hu ELISA Kit for Kruppel Like Factor 4, Gut (KLF4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB241Mu01 Recombinant Kruppel Like Factor 4, Gut (KLF4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB241Mu01 Polyclonal Antibody to Kruppel Like Factor 4, Gut (KLF4) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Kruppel Like Factor 4, Gut (KLF4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Kruppel Like Factor 4, Gut (KLF4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB241Ra01 Recombinant Kruppel Like Factor 4, Gut (KLF4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB241Ra01 Polyclonal Antibody to Kruppel Like Factor 4, Gut (KLF4) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Kruppel Like Factor 4, Gut (KLF4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Kruppel Like Factor 4, Gut (KLF4) ELISA Kit Customized Service Offer
  1. "Human EZF, a Kruppel-like zinc finger protein, is expressed in vascular endothelial cells and contains transcriptional activation and repression domains."J. Biol. Chem. 273:1026-1031(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Oncogene expression cloning by retroviral transduction of adenovirus E1A-immortalized rat kidney RK3E cells: transformation of a host with epithelial features by c-MYC and the zinc finger protein GKLF."Cell Growth Differ. 10:423-434(1999) [PubMed] [Europe PMC] [Abstract]
  3. "Shaking the family tree: Identification of novel and biologically active alternatively spliced isoforms across the KLF family of transcription factors."FASEB J. 27:432-436(2013) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Human mucin 1 oncoprotein represses transcription of the p53 tumor suppressor gene."Cancer Res. 67:1853-1858(2007) [PubMed] [Europe PMC] [Abstract]
  8. "Induction of pluripotent stem cells from adult human fibroblasts by defined factors."Cell 131:861-872(2007) [PubMed] [Europe PMC] [Abstract]
  9. "Nine-amino-acid transactivation domain: establishment and prediction utilities."Genomics 89:756-768(2007) [PubMed] [Europe PMC] [Abstract]
  10. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Proteomic analysis of ubiquitinated proteins in normal hepatocyte cell line Chang liver cells."Proteomics 8:2885-2896(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Kruppel-like factor 4 (Klf4) prevents embryonic stem (ES) cell differentiation by regulating Nanog gene expression."J. Biol. Chem. 285:9180-9189(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  14. "Cooperative transcriptional activation by Klf4, Meis2, and Pbx1."Mol. Cell. Biol. 31:3723-3733(2011) [PubMed] [Europe PMC] [Abstract]
  15. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]