Mitogen Activated Protein Kinase 14 (MAPK14)

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CSBP1; CSBP2; CSPB1; EXIP; Mxi2; PRKM14; PRKM15; RK; SAPK2A; P38; Mitogen-activated protein kinase p38 alpha; Cytokine suppressive anti-inflammatory drug-binding protein

Mitogen Activated Protein Kinase 14 (MAPK14)

Mitogen-activated protein kinase 14 is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB206Hu01 Recombinant Mitogen Activated Protein Kinase 14 (MAPK14) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB206Hu01 Polyclonal Antibody to Mitogen Activated Protein Kinase 14 (MAPK14) WB; IHC; ICC; IP.
MAB206Hu22 Monoclonal Antibody to Mitogen Activated Protein Kinase 14 (MAPK14) WB; IHC; ICC; IP.
Assay Kits SEB206Hu ELISA Kit for Mitogen Activated Protein Kinase 14 (MAPK14) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mitogen Activated Protein Kinase 14 (MAPK14) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mitogen Activated Protein Kinase 14 (MAPK14) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mitogen Activated Protein Kinase 14 (MAPK14) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mitogen Activated Protein Kinase 14 (MAPK14) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mitogen Activated Protein Kinase 14 (MAPK14) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB206Ra01 Recombinant Mitogen Activated Protein Kinase 14 (MAPK14) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB206Ra01 Polyclonal Antibody to Mitogen Activated Protein Kinase 14 (MAPK14) WB; IHC; ICC; IP.
MAB206Ra21 Monoclonal Antibody to Mitogen Activated Protein Kinase 14 (MAPK14) WB; IHC; ICC; IP.
Assay Kits SEB206Ra ELISA Kit for Mitogen Activated Protein Kinase 14 (MAPK14) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "A protein kinase involved in the regulation of inflammatory cytokine biosynthesis."Nature 372:739-746(1994) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular cloning of human p38 MAP kinase."Biochim. Biophys. Acta 1265:224-227(1995) [PubMed] [Europe PMC] [Abstract]
  3. "Mxi2, a mitogen-activated protein kinase that recognizes and phosphorylates Max protein."Proc. Natl. Acad. Sci. U.S.A. 92:10531-10534(1995) [PubMed] [Europe PMC] [Abstract]
  4. "Structure and polymorphism of two stress-activated protein kinase genes centromeric of the MHC: SAPK2a and SAPK4."DNA Seq. 10:229-243(1999) [PubMed] [Europe PMC] [Abstract]
  5. "Exip, a new alternative splicing variant of p38 alpha, can induce an earlier onset of apoptosis in HeLa cells."Biochem. Biophys. Res. Commun. 291:838-843(2002) [PubMed] [Europe PMC] [Abstract]
  6. "Discovery of novel human transcript variants by analysis of intronic single-block EST with polyadenylation site."BMC Genomics 10:518-518(2009) [PubMed] [Europe PMC] [Abstract]
  7. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  8. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
  11. "Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of Hsp27."Cell 78:1039-1049(1994) [PubMed] [Europe PMC] [Abstract]
  12. "Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine."J. Biol. Chem. 270:7420-7426(1995) [PubMed] [Europe PMC] [Abstract]
  13. "Human mitogen-activated protein kinase CSBP1, but not CSBP2, complements a hog1 deletion in yeast."J. Biol. Chem. 270:29043-29046(1995) [PubMed] [Europe PMC] [Abstract]
  14. "MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway."Mol. Cell. Biol. 16:1247-1255(1996) [PubMed] [Europe PMC] [Abstract]
  15. "Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB."EMBO J. 17:4426-4441(1998) [PubMed] [Europe PMC] [Abstract]
  16. "Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6."J. Biol. Chem. 273:1741-1748(1998) [PubMed] [Europe PMC] [Abstract]
  17. "RSK-B, a novel ribosomal S6 kinase family member, is a CREB kinase under dominant control of p38alpha mitogen-activated protein kinase (p38alphaMAPK)."J. Biol. Chem. 273:29661-29671(1998) [PubMed] [Europe PMC] [Abstract]
  18. "Molecular cloning and characterization of a novel dual specificity phosphatase, MKP-5."J. Biol. Chem. 274:19949-19956(1999) [PubMed] [Europe PMC] [Abstract]
  19. "Regulation of the MEF2 family of transcription factors by p38."Mol. Cell. Biol. 19:21-30(1999) [PubMed] [Europe PMC] [Abstract]
  20. "Targeting of p38 mitogen-activated protein kinases to MEF2 transcription factors."Mol. Cell. Biol. 19:4028-4038(1999) [PubMed] [Europe PMC] [Abstract]
  21. "Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis."Cell 102:221-231(2000) [PubMed] [Europe PMC] [Abstract]
  22. "Distinct carboxy-termini confer divergent characteristics to the mitogen-activated protein kinase p38alpha and its splice isoform Mxi2."FEBS Lett. 474:169-174(2000) [PubMed] [Europe PMC] [Abstract]
  23. "Stress-induced activation of protein kinase CK2 by direct interaction with p38 mitogen-activated protein kinase."J. Biol. Chem. 275:16569-16573(2000) [PubMed] [Europe PMC] [Abstract]
  24. "Differential activation of p38 mitogen-activated protein kinase isoforms depending on signal strength."J. Biol. Chem. 275:40641-40648(2000) [PubMed] [Europe PMC] [Abstract]
  25. "Distinct binding determinants for ERK2/p38alpha and JNK map kinases mediate catalytic activation and substrate selectivity of map kinase phosphatase-1."J. Biol. Chem. 276:16491-16500(2001) [PubMed] [Europe PMC] [Abstract]
  26. "A Novel MAPK phosphatase MKP-7 acts preferentially on JNK/SAPK and p38 alpha and beta MAPKs."J. Biol. Chem. 276:26629-26639(2001) [PubMed] [Europe PMC] [Abstract]
  27. "The mitogen-activated protein kinase signal-integrating kinase Mnk2 is a eukaryotic initiation factor 4E kinase with high levels of basal activity in mammalian cells."Mol. Cell. Biol. 21:743-754(2001) [PubMed] [Europe PMC] [Abstract]
  28. "Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase."Nature 411:102-107(2001) [PubMed] [Europe PMC] [Abstract]
  29. "MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha."Science 295:1291-1294(2002) [PubMed] [Europe PMC] [Abstract]
  30. "Active mutants of the human p38alpha mitogen-activated protein kinase."J. Biol. Chem. 279:47040-47049(2004) [PubMed] [Europe PMC] [Abstract]
  31. "Myeloid-related protein-14 is a p38 MAPK substrate in human neutrophils."J. Immunol. 174:7257-7267(2005) [PubMed] [Europe PMC] [Abstract]
  32. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
  33. "Alternative p38 activation pathway mediated by T cell receptor-proximal tyrosine kinases."Nat. Immunol. 6:390-395(2005) [PubMed] [Europe PMC] [Abstract]
  34. "The autoimmune suppressor Gadd45alpha inhibits the T cell alternative p38 activation pathway."Nat. Immunol. 6:396-402(2005) [PubMed] [Europe PMC] [Abstract]
  35. "p38 and a p38-interacting protein are critical for downregulation of E-cadherin during mouse gastrulation."Cell 125:957-969(2006) [PubMed] [Europe PMC] [Abstract]
  36. "p38 MAP kinase mediates stress-induced internalization of EGFR: implications for cancer chemotherapy."EMBO J. 25:4195-4206(2006) [PubMed] [Europe PMC] [Abstract]
  37. "Regulation of the ring finger E3 ligase Siah2 by p38 MAPK."J. Biol. Chem. 281:35316-35326(2006) [PubMed] [Europe PMC] [Abstract]
  38. "Nuclear protein NP60 regulates p38 MAPK activity."J. Cell Sci. 119:115-123(2006) [PubMed] [Europe PMC] [Abstract]
  39. "p38alpha antagonizes p38gamma activity through c-Jun-dependent ubiquitin-proteasome pathways in regulating Ras transformation and stress response."J. Biol. Chem. 282:31398-31408(2007) [PubMed] [Europe PMC] [Abstract]
  40. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  41. "Phosphoproteome of resting human platelets."J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]
  42. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  43. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  44. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  45. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  46. "Coordinated regulation of autophagy by p38alpha MAPK through mAtg9 and p38IP."EMBO J. 29:27-40(2010) [PubMed] [Europe PMC] [Abstract]
  47. "DNA damage activates a spatially distinct late cytoplasmic cell-cycle checkpoint network controlled by MK2-mediated RNA stabilization."Mol. Cell 40:34-49(2010) [PubMed] [Europe PMC] [Abstract]
  48. "Direct activation of TACE-mediated ectodomain shedding by p38 MAP kinase regulates EGF receptor-dependent cell proliferation."Mol. Cell 37:551-566(2010) [PubMed] [Europe PMC] [Abstract]
  49. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  50. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  51. "Acetylation of a conserved lysine residue in the ATP binding pocket of p38 augments its kinase activity during hypertrophy of cardiomyocytes."Mol. Cell. Biol. 31:2349-2363(2011) [PubMed] [Europe PMC] [Abstract]
  52. "In the cellular garden of forking paths: how p38 MAPKs signal for downstream assistance."Biol. Chem. 383:1519-1536(2002) [PubMed] [Europe PMC] [Abstract]
  53. "Mechanisms and functions of p38 MAPK signalling."Biochem. J. 429:403-417(2010) [PubMed] [Europe PMC] [Abstract]
  54. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  55. "Crystal structure of p38 mitogen-activated protein kinase."J. Biol. Chem. 271:27696-27700(1996) [PubMed] [Europe PMC] [Abstract]
  56. "A highly specific inhibitor of human p38 MAP kinase binds in the ATP pocket."Nat. Struct. Biol. 4:311-316(1997) [PubMed] [Europe PMC] [Abstract]
  57. "Structural basis of inhibitor selectivity in MAP kinases."Structure 6:1117-1128(1998) [PubMed] [Europe PMC] [Abstract]
  58. "Binding mode of the 4-anilinoquinazoline class of protein kinase inhibitor: X-ray crystallographic studies of 4-anilinoquinazolines bound to cyclin-dependent kinase 2 and p38 kinase."J. Med. Chem. 43:133-138(2000) [PubMed] [Europe PMC] [Abstract]
  59. "Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site."Nat. Struct. Biol. 9:268-272(2002) [PubMed] [Europe PMC] [Abstract]
  60. "Design and synthesis of potent, orally bioavailable dihydroquinazolinone inhibitors of p38 MAP kinase."Bioorg. Med. Chem. Lett. 13:277-280(2003) [PubMed] [Europe PMC] [Abstract]
  61. "Design and synthesis of 4-azaindoles as inhibitors of p38 MAP kinase." J. Med. Chem. 46:4702-4713(2003) [PubMed] [Europe PMC] [Abstract]
  62. "Structural basis for p38alpha MAP kinase quinazolinone and pyridol-pyrimidine inhibitor specificity."Nat. Struct. Biol. 10:764-769(2003) [PubMed] [Europe PMC] [Abstract]
  63. "Lattice stabilization and enhanced diffraction in human p38 alpha crystals by protein engineering."Biochim. Biophys. Acta 1696:67-73(2004) [PubMed] [Europe PMC] [Abstract]
  64. "Prevention of MKK6-dependent activation by binding to p38alpha MAP kinase."Biochemistry 44:16475-16490(2005) [PubMed] [Europe PMC] [Abstract]
  65. "Design and synthesis of potent pyridazine inhibitors of p38 MAP kinase."Bioorg. Med. Chem. Lett. 15:2409-2413(2005) [PubMed] [Europe PMC] [Abstract]
  66. "Two classes of p38alpha MAP kinase inhibitors having a common diphenylether core but exhibiting divergent binding modes."Bioorg. Med. Chem. Lett. 15:5274-5279(2005) [PubMed] [Europe PMC] [Abstract]
  67. "Fragment-based lead discovery using X-ray crystallography."J. Med. Chem. 48:403-413(2005) [PubMed] [Europe PMC] [Abstract]
  68. "Crystal structure of the p38 alpha-MAPKAP kinase 2 heterodimer."J. Biol. Chem. 282:9733-9739(2007) [PubMed] [Europe PMC] [Abstract]
  69. ErratumJ. Biol. Chem. 282:14684-14684(2007)
  70. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]