Glucose Transporter 1 (GLUT1)

[Edit]

SLC2A1; SLC2-A1; GLUT; Solute Carrier Family 2 Member 1,Facilitated Glucose Transporter; Glucose transporter type 1, erythrocyte/brain; HepG2 glucose transporter

Glucose Transporter 1 (GLUT1)

GLUT1 facilitates the transport of glucose across the plasma membranes of mammalian cells.GLUT1 is responsible for the low-level of basal glucose uptake required to sustain respiration in all cells. Expression levels of GLUT1 in cell membranes are increased by reduced glucose levels and decreased by increased glucose levels. GLUT1 is also a major receptor for take-up of Vitamin C as well as glucose, especially in non vitamin C producing mammals as part of an adaptation to compensate by participating in a Vitamin C recycling process. In mammals that do produce Vitamin C, GLUT4 is often expressed instead of GLUT1.GLUT1 behaves as a Michaelis-Menten enzyme and contains 12 membrane-spanning alpha helices, each containing 20 amino acid residues.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB185Hu01 Recombinant Glucose Transporter 1 (GLUT1) Positive Control; Immunogen; SDS-PAGE; WB.
RPB185Hu02 Recombinant Glucose Transporter 1 (GLUT1) Positive Control; Immunogen; SDS-PAGE; WB.
CPB185Hu21 OVA Conjugated Glucose Transporter 1 (GLUT1) Immunogen; SDS-PAGE; WB.
Antibodies PAB185Hu01 Polyclonal Antibody to Glucose Transporter 1 (GLUT1) WB
MAB185Hu22 Monoclonal Antibody to Glucose Transporter 1 (GLUT1) WB,IHC
PAB185Hu02 Polyclonal Antibody to Glucose Transporter 1 (GLUT1) WB; IHC; ICC; IP.
LAB185Hu71 Biotin-Linked Polyclonal Antibody to Glucose Transporter 1 (GLUT1) WB; IHC; ICC.
MAB185Hu21 Monoclonal Antibody to Glucose Transporter 1 (GLUT1) WB
MAB185Hu23 Monoclonal Antibody to Glucose Transporter 1 (GLUT1) WB
Assay Kits SEB185Hu ELISA Kit for Glucose Transporter 1 (GLUT1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB185Mu01 Recombinant Glucose Transporter 1 (GLUT1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Glucose Transporter 1 (GLUT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Glucose Transporter 1 (GLUT1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Glucose Transporter 1 (GLUT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Glucose Transporter 1 (GLUT1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB185Ra01 Recombinant Glucose Transporter 1 (GLUT1) Positive Control; Immunogen; SDS-PAGE; WB.
RPB185Ra02 Recombinant Glucose Transporter 1 (GLUT1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB185Ra01 Polyclonal Antibody to Glucose Transporter 1 (GLUT1) WB; IHC; ICC; IP.
MAB185Ra21 Monoclonal Antibody to Glucose Transporter 1 (GLUT1) WB; IHC; ICC; IP.
Assay Kits SEB185Ra ELISA Kit for Glucose Transporter 1 (GLUT1) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Sequence and structure of a human glucose transporter."Science 229:941-945(1985) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Characterization and expression of human HepG2/erythrocyte glucose-transporter gene."Diabetes 37:657-661(1988) [PubMed] [Europe PMC] [Abstract]
  5. "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes."J. Proteome Res. 5:3135-3144(2006) [PubMed] [Europe PMC] [Abstract]
  6. "Transmembrane segment 6 of the Glut1 glucose transporter is an outer helix and contains amino acid side chains essential for transport activity."J. Biol. Chem. 283:11550-11555(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Dematin and adducin provide a novel link between the spectrin cytoskeleton and human erythrocyte membrane by directly interacting with glucose transporter-1."J. Biol. Chem. 283:14600-14609(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Model of the exofacial substrate-binding site and helical folding of the human Glut1 glucose transporter based on scanning mutagenesis."Biochemistry 48:5934-5942(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  14. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  15. "Stomatin interacts with GLUT1/SLC2A1, band 3/SLC4A1, and aquaporin-1 in human erythrocyte membrane domains."Biochim. Biophys. Acta 1828:956-966(2013) [PubMed] [Europe PMC] [Abstract]
  16. "A global analysis of SNX27-retromer assembly and cargo specificity reveals a function in glucose and metal ion transport."Nat. Cell Biol. 15:461-471(2013) [PubMed] [Europe PMC] [Abstract]
  17. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  18. "Crystal structure of the human glucose transporter GLUT1."Nature 510:121-125(2014) [PubMed] [Europe PMC] [Abstract]
  19. "Defective glucose transport across brain tissue barriers: a newly recognized neurological syndrome."Neurochem. Res. 24:587-594(1999) [PubMed] [Europe PMC] [Abstract]
  20. "Mutational analysis of GLUT1 (SLC2A1) in Glut-1 deficiency syndrome."Hum. Mutat. 16:224-231(2000) [PubMed] [Europe PMC] [Abstract]
  21. ErratumHum. Mutat. 16:527-527(2000)
  22. "Autosomal dominant Glut-1 deficiency syndrome and familial epilepsy."Ann. Neurol. 50:476-485(2001) [PubMed] [Europe PMC] [Abstract]
  23. "Autosomal dominant transmission of GLUT1 deficiency."Hum. Mol. Genet. 10:63-68(2001) [PubMed] [Europe PMC] [Abstract]
  24. "Imaging the metabolic footprint of Glut1 deficiency on the brain."Ann. Neurol. 52:458-464(2002) [PubMed] [Europe PMC] [Abstract]
  25. "GLUT-1 deficiency without epilepsy -- an exceptional case."J. Inherit. Metab. Dis. 26:559-563(2003) [PubMed] [Europe PMC] [Abstract]
  26. "Glut-1 deficiency syndrome: clinical, genetic, and therapeutic aspects."Ann. Neurol. 57:111-118(2005) [PubMed] [Europe PMC] [Abstract]
  27. "GLUT1 mutations are a cause of paroxysmal exertion-induced dyskinesias and induce hemolytic anemia by a cation leak." J. Clin. Invest. 118:2157-2168(2008) [PubMed] [Europe PMC] [Abstract]
  28. "Early-onset absence epilepsy caused by mutations in the glucose transporter GLUT1."Ann. Neurol. 66:415-419(2009) [PubMed] [Europe PMC] [Abstract]
  29. "Childhood chorea with cerebral hypotrophy: a treatable GLUT1 energy failure syndrome."Arch. Neurol. 66:1410-1414(2009) [PubMed] [Europe PMC] [Abstract]
  30. "GLUT1 gene mutations cause sporadic paroxysmal exercise-induced dyskinesias."Mov. Disord. 24:1684-1688(2009) [PubMed] [Europe PMC] [Abstract]
  31. "Autosomal recessive inheritance of GLUT1 deficiency syndrome."Neuropediatrics 40:207-210(2009) [PubMed] [Europe PMC] [Abstract]
  32. "Glucose transporter-1 deficiency syndrome: the expanding clinical and genetic spectrum of a treatable disorder." Brain 133:655-670(2010) [PubMed] [Europe PMC] [Abstract]
  33. "Mild adolescent/adult onset epilepsy and paroxysmal exercise-induced dyskinesia due to GLUT1 deficiency."Epilepsia 51:2466-2469(2010) [PubMed] [Europe PMC] [Abstract]
  34. "Paroxysmal exercise-induced dyskinesia, writer's cramp, migraine with aura and absence epilepsy in twin brothers with a novel SLC2A1 missense mutation."J. Neurol. Sci. 295:110-113(2010) [PubMed] [Europe PMC] [Abstract]
  35. "Absence epilepsies with widely variable onset are a key feature of familial GLUT1 deficiency."Neurology 75:432-440(2010) [PubMed] [Europe PMC] [Abstract]
  36. "Excellent response to acetazolamide in a case of paroxysmal dyskinesias due to GLUT1-deficiency."J. Neurol. 258:316-317(2011) [PubMed] [Europe PMC] [Abstract]
  37. "Paroxysmal choreoathetosis/spasticity (DYT9) is caused by a GLUT1 defect."Neurology 77:959-964(2011) [PubMed] [Europe PMC] [Abstract]
  38. "GLUT1 mutations are a rare cause of familial idiopathic generalized epilepsy."Neurology 78:557-562(2012) [PubMed] [Europe PMC] [Abstract]