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Mitogen Activated Protein Kinase Kinase Kinase 1 (MAP3K1)

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MAP3-K1; MAPKKK1; MEKK; MEKK1

Mitogen Activated Protein Kinase Kinase Kinase 1 (MAP3K1)
CCC B145
HGNC 6848
MGI 1346872
PubMed 20128690
RGD 620966
UniProt Q13233
Wiki MAP3K1

MAP3K is a serine/threonine kinase that occupies a pivotal role in a network of phosphorylating enzymes integrating cellular responses to a number of mitogenic and metabolic stimuli, including insulin and many growth factors.Mouse genetics has revealed that the kinase is important in: correct embryogenesis, keratinocyte migration, T cell cytokine production and B cell antibody production.Vinik et al. identified DNA sequence and size polymorphisms in intronic and 3-prime untranslated regions of the mouse Map3k1 gene and the human MAP3K1 homolog. Using these allele-specific polymorphisms, they mapped the Map3k1 gene in an intersubspecific backcross to mouse chromosome 13. They mapped the human MAP3K1 gene to chromosome 5 by somatic cell hybrid analysis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB145Hu01 Recombinant Mitogen Activated Protein Kinase Kinase Kinase 1 (MAP3K1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB145Hu01 Polyclonal Antibody to Mitogen Activated Protein Kinase Kinase Kinase 1 (MAP3K1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Mitogen Activated Protein Kinase Kinase Kinase 1 (MAP3K1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mitogen Activated Protein Kinase Kinase Kinase 1 (MAP3K1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mitogen Activated Protein Kinase Kinase Kinase 1 (MAP3K1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mitogen Activated Protein Kinase Kinase Kinase 1 (MAP3K1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mitogen Activated Protein Kinase Kinase Kinase 1 (MAP3K1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mitogen Activated Protein Kinase Kinase Kinase 1 (MAP3K1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mitogen Activated Protein Kinase Kinase Kinase 1 (MAP3K1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mitogen Activated Protein Kinase Kinase Kinase 1 (MAP3K1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mitogen Activated Protein Kinase Kinase Kinase 1 (MAP3K1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mitogen Activated Protein Kinase Kinase Kinase 1 (MAP3K1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mitogen Activated Protein Kinase Kinase Kinase 1 (MAP3K1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mitogen Activated Protein Kinase Kinase Kinase 1 (MAP3K1) ELISA Kit Customized Service Offer
  1. "The DNA sequence and comparative analysis of human chromosome 5." Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
  2. "JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extension."Genes Dev. 12:3369-3381(1998) [PubMed] [Europe PMC] [Abstract]
  3. "Mapping of the MEK kinase gene (Mekk) to mouse chromosome 13 and human chromosome 5."Mamm. Genome 6:782-783(1995) [PubMed] [Europe PMC] [Abstract]
  4. "SUMO-1 modification of the C-terminal KVEKVD of Axin is required for JNK activation but has no effect on Wnt signaling."J. Biol. Chem. 277:42981-42986(2002) [PubMed] [Europe PMC] [Abstract]
  5. "The DIX domain protein coiled-coil-DIX1 inhibits c-Jun N-terminal kinase activation by Axin and dishevelled through distinct mechanisms."J. Biol. Chem. 279:39366-39373(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Negative regulation of MEKK1/2 signaling by serine-threonine kinase 38 (STK38)."Oncogene 27:1930-1938(2008) [PubMed] [Europe PMC] [Abstract]
  9. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
  13. "Mutations in MAP3K1 cause 46,XY disorders of sex development and implicate a common signal transduction pathway in human testis determination." Am. J. Hum. Genet. 87:898-904(2010) [PubMed] [Europe PMC] [Abstract]