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Motility Related Protein (MRP1)

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CD9; TSPAN29; 5H9; BA2; BTCC-1; DRAP-27; GIG2; MIC3; P24; Tetraspanin 29; Cell growth-inhibiting gene 2 protein; Leukocyte antigen MIC3

Motility Related Protein (MRP1)
CCC B097
HGNC 1709
MGI 88348
PubMed 12966509
RGD 2318
UniProt P21926
Wiki CD9

Motility related protein is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility.

This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It can modulate cell adhesion and migration and also trigger platelet activation and aggregation. In addition, the protein appears to promote muscle cell fusion and support myotube maintenance.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB097Hu01 Recombinant Motility Related Protein (MRP1) Positive Control; Immunogen; SDS-PAGE; WB.
EPB097Hu61 Eukaryotic Motility Related Protein (MRP1) Positive Control; Immunogen; SDS-PAGE; WB.
APB097Hu61 Active Motility Related Protein (MRP1) Cell culture; Activity Assays.
APB097Hu01 Active Motility Related Protein (MRP1) Cell culture; Activity Assays.
Antibodies PAB097Hu01 Polyclonal Antibody to Motility Related Protein (MRP1) WB; IHC; ICC; IP.
MAB097Hu22 Monoclonal Antibody to Motility Related Protein (MRP1) WB; IHC; ICC; IP.
MAB097Hu21 Monoclonal Antibody to Motility Related Protein (MRP1) WB; IHC; ICC; IP.
Assay Kits SEB097Hu ELISA Kit for Motility Related Protein (MRP1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Motility Related Protein (MRP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Motility Related Protein (MRP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Motility Related Protein (MRP1) Polyclonal Antibody Customized Service Offer
Assay Kits SEB097Mu ELISA Kit for Motility Related Protein (MRP1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Motility Related Protein (MRP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Motility Related Protein (MRP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Motility Related Protein (MRP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Motility Related Protein (MRP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Motility Related Protein (MRP1) ELISA Kit Customized Service Offer
  1. "Molecular cloning of the CD9 antigen. A new family of cell surface proteins."J. Biol. Chem. 266:117-122(1991) [PubMed] [Europe PMC] [Abstract]
  2. "cDNA cloning and expression of platelet p24/CD9. Evidence for a new family of multiple membrane-spanning proteins."J. Biol. Chem. 266:10638-10645(1991) [PubMed] [Europe PMC] [Abstract]
  3. "Identification of the motility-related protein (MRP-1), recognized by monoclonal antibody M31-15, which inhibits cell motility."J. Exp. Med. 174:1347-1354(1991) [PubMed] [Europe PMC] [Abstract]
  4. "Organization of the human CD9 gene."Genomics 16:132-138(1993) [PubMed] [Europe PMC] [Abstract]
  5. "The tetraspanin CD9 is preferentially expressed on the human CD4(+)CD45RA+ naive T cell population and is involved in T cell activation."Clin. Exp. Immunol. 137:101-108(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Purification and partial characterization of CD9 antigen of human platelets."FEBS Lett. 264:270-274(1990) [PubMed] [Europe PMC] [Abstract]
  8. "Suppression of cell motility and metastasis by transfection with human motility-related protein (MRP-1/CD9) DNA."J. Exp. Med. 177:1231-1237(1993) [PubMed] [Europe PMC] [Abstract]
  9. "CD9-regulated adhesion. Anti-CD9 monoclonal antibody induce pre-B cell adhesion to bone marrow fibroblasts through de novo recognition of fibronectin."J. Immunol. 152:2768-2777(1994) [PubMed] [Europe PMC] [Abstract]
  10. "Structural requirements for the inhibitory action of the CD9 large extracellular domain in sperm/oocyte binding and fusion."Biochem. Biophys. Res. Commun. 311:208-214(2003) [PubMed] [Europe PMC] [Abstract]
  11. "Evidence for specific tetraspanin homodimers: inhibition of palmitoylation makes cysteine residues available for cross-linking."Biochem. J. 377:407-417(2004) [PubMed] [Europe PMC] [Abstract]
  12. "Differential stability of tetraspanin/tetraspanin interactions: role of palmitoylation."FEBS Lett. 516:139-144(2002) [PubMed] [Europe PMC] [Abstract]
  13. "The major CD9 and CD81 molecular partner. Identification and characterization of the complexes."J. Biol. Chem. 276:14329-14337(2001) [PubMed] [Europe PMC] [Abstract]
  14. "EWI-2 is a major CD9 and CD81 partner and member of a novel Ig protein subfamily."J. Biol. Chem. 276:40545-40554(2001) [PubMed] [Europe PMC] [Abstract]
  15. "Palmitoylation supports the association of tetraspanin CD63 with CD9 and integrin alphaIIbbeta3 in activated platelets."Thromb. Res. 125:152-158(2010) [PubMed] [Europe PMC] [Abstract]
  16. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]