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Cholecystokinin B Receptor (CCKBR)

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CCK-B; CCK2; GASR; Gastrin Receptor; Cholecystokinin-2 receptor

Cholecystokinin B Receptor (CCKBR)
CCC B051
HGNC 1571
MGI 99479
PubMed 8222757
RGD 2290
UniProt P32239
Wiki CCKBR
The Cholecystokinin B receptor is also known as CCKBR or CCK2, with CCK2 now being the IUPHAR-recommended name. This gene encodes a G-protein coupled receptor for gastrin and cholecystokinin (CCK), regulatory peptides of the brain and gastrointestinal tract.
This protein is a type B gastrin receptor, which has a high affinity for both sulfated and nonsulfated CCK analogs and is found principally in the central nervous system and the gastrointestinal tract. A misspliced transcript variant including an intron has been observed in cells from colorectal and pancreatic tumors. Cholecystokinin B receptor has been shown to interact with Cholecystokinin.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB051Hu01 Recombinant Cholecystokinin B Receptor (CCKBR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB051Hu01 Polyclonal Antibody to Cholecystokinin B Receptor (CCKBR) WB; IHC; ICC; IP.
MAB051Hu22 Monoclonal Antibody to Cholecystokinin B Receptor (CCKBR) WB; IHC; ICC; IP.
Assay Kits SEB051Hu ELISA Kit for Cholecystokinin B Receptor (CCKBR) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cholecystokinin B Receptor (CCKBR) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cholecystokinin B Receptor (CCKBR) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cholecystokinin B Receptor (CCKBR) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cholecystokinin B Receptor (CCKBR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cholecystokinin B Receptor (CCKBR) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cholecystokinin B Receptor (CCKBR) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cholecystokinin B Receptor (CCKBR) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cholecystokinin B Receptor (CCKBR) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cholecystokinin B Receptor (CCKBR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cholecystokinin B Receptor (CCKBR) ELISA Kit Customized Service Offer
  1. "Molecular cloning of the human brain and gastric cholecystokinin receptor: structure, functional expression and chromosomal localization."Biochem. Biophys. Res. Commun. 189:296-303(1992) [PubMed] [Europe PMC] [Abstract]
  2. "The human brain cholecystokinin-B/gastrin receptor. Cloning and characterization."J. Biol. Chem. 268:8164-8169(1993) [PubMed] [Europe PMC] [Abstract]
  3. "Functional characterization of a human brain cholecystokinin-B receptor. A trophic effect of cholecystokinin and gastrin."J. Biol. Chem. 268:18300-18305(1993) [PubMed] [Europe PMC] [Abstract]
  4. "The human gastrin/cholecystokinin type B receptor gene: alternative splice donor site in exon 4 generates two variant mRNAs."Proc. Natl. Acad. Sci. U.S.A. 90:9085-9089(1993) [PubMed] [Europe PMC] [Abstract]
  5. "Cholecystokinin stimulates Ca2+ mobilization and clonal growth in small cell lung cancer through CCKA and CCKB/gastrin receptors."Ann. N. Y. Acad. Sci. 713:283-297(1994) [PubMed] [Europe PMC] [Abstract]
  6. "Functional characterization of two cholecystokinin-B/gastrin receptor isoforms: a preferential splice donor site in the human receptor gene."Cell Growth Differ. 5:1127-1135(1994) [PubMed] [Europe PMC] [Abstract]
  7. "A truncated isoform of human CCK-B/gastrin receptor generated by alternative usage of a novel exon."Biochem. Biophys. Res. Commun. 208:230-237(1995) [PubMed] [Europe PMC] [Abstract]
  8. "Human colorectal cancers express a constitutively active cholecystokinin-B/gastrin receptor that stimulates cell growth."J. Biol. Chem. 275:32122-32128(2000) [PubMed] [Europe PMC] [Abstract]
  9. "Identification of CCK-B/gastrin receptor splice variants in human peripheral blood mononuclear cells."Regul. Pept. 101:25-33(2001) [PubMed] [Europe PMC] [Abstract]
  10. "Characterization of the CCK-C (cancer) receptor in human pancreatic cancer."Int. J. Mol. Med. 10:689-694(2002) [PubMed] [Europe PMC] [Abstract]
  11. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  12. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  13. "An 84-kilobase physical map and repeat polymorphisms of the gastrin/cholecystokinin brain receptor region at the junction of chromosome segments 11p15.4 and 15.5."Chromosome Res. 6:415-418(1998) [PubMed] [Europe PMC] [Abstract]
  14. "CCKA and CCKB receptors are expressed in small cell lung cancer lines and mediate Ca2+ mobilization and clonal growth."Cancer Res. 53:5208-5213(1993) [PubMed] [Europe PMC] [Abstract]
  15. "Localization of the human cholecystokinin-B/gastrin receptor gene (CCKBR) to chromosome 11p15.5-->p15.4 by fluorescence in situ hybridization."Cytogenet. Cell Genet. 65:184-185(1994) [PubMed] [Europe PMC] [Abstract]
  16. "Intermolecular interactions between cholecystokinin-8 and the third extracellular loop of the cholecystokinin-2 receptor."Biochemistry 41:4560-4566(2002) [PubMed] [Europe PMC] [Abstract]