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Glypican 1 (GPC1)

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Glypican Proteoglycan 1; Secreted glypican-1

Glypican 1 (GPC1)
CCC B032
HGNC 4449
MGI 1194891
PubMed 18064304
RGD 61853
UniProt P35052
Wiki Glypican_1

Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation.

Moreover, athymic mice lacking Gpc1 exhibited decreased tumor angiogenesis and metastases following intrapancreatic implantation with human pancreatic cancer cells and fewer pulmonary metastases following intravenous injection of mouse melanoma cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB032Hu01 Recombinant Glypican 1 (GPC1) Positive Control; Immunogen; SDS-PAGE; WB.
APB032Hu01 Active Glypican 1 (GPC1) Cell culture; Activity Assays.
Antibodies PAB032Hu01 Polyclonal Antibody to Glypican 1 (GPC1) WB; IHC; ICC; IP.
MAB032Hu22 Monoclonal Antibody to Glypican 1 (GPC1) WB; IHC; ICC; IP.
LAB032Hu71 Biotin-Linked Polyclonal Antibody to Glypican 1 (GPC1) WB; IHC; ICC.
LAB032Hu81 FITC-Linked Polyclonal Antibody to Glypican 1 (GPC1) WB; IHC; ICC; IF.
Assay Kits SEB032Hu ELISA Kit for Glypican 1 (GPC1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB032Mu01 Recombinant Glypican 1 (GPC1) Positive Control; Immunogen; SDS-PAGE; WB.
RPB032Mu02 Recombinant Glypican 1 (GPC1) Positive Control; Immunogen; SDS-PAGE; WB.
APB032Mu01 Active Glypican 1 (GPC1) Cell culture; Activity Assays.
APB032Mu02 Active Glypican 1 (GPC1) Cell culture; Activity Assays.
Antibodies PAB032Mu01 Polyclonal Antibody to Glypican 1 (GPC1) WB; IHC; ICC; IP.
PAB032Mu02 Polyclonal Antibody to Glypican 1 (GPC1) WB; IHC; ICC; IP.
LAB032Mu71 Biotin-Linked Polyclonal Antibody to Glypican 1 (GPC1) WB; IHC; ICC.
Assay Kits SEB032Mu ELISA Kit for Glypican 1 (GPC1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Glypican 1 (GPC1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Glypican 1 (GPC1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Glypican 1 (GPC1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Glypican 1 (GPC1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Glypican 1 (GPC1) ELISA Kit Customized Service Offer
  1. "Molecular cloning of a phosphatidylinositol-anchored membrane heparan sulfate proteoglycan from human lung fibroblasts."J. Cell Biol. 111:3165-3176(1990) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Prion, amyloid beta-derived Cu(II) ions, or free Zn(II) ions support S-nitroso-dependent autocleavage of glypican-1 heparan sulfate."J. Biol. Chem. 278:38956-38965(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Glypican-1 as an Abeta binding HSPG in the human brain: its localization in DIG domains and possible roles in the pathogenesis of Alzheimer's disease."FASEB J. 18:1013-1015(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Defective nitric oxide-dependent, deaminative cleavage of glypican-1 heparan sulfate in Niemann-Pick C1 fibroblasts."Glycobiology 16:711-718(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Constitutive and vitamin C-induced, NO-catalyzed release of heparan sulfate from recycling glypican-1 in late endosomes."Glycobiology 16:1251-1261(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Chemical and thermal unfolding of glypican-1: protective effect of heparan sulfate against heat-induced irreversible aggregation."Biochemistry 48:9994-10004(2009) [PubMed] [Europe PMC] [Abstract]
  10. "S-Nitrosylation of secreted recombinant human glypican-1."Glycoconj. J. 26:1247-1257(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Glypican-1 mediates both prion protein lipid raft association and disease isoform formation."PLoS Pathog. 5:E1000666-E1000666(2009) [PubMed] [Europe PMC] [Abstract]
  12. "The structural role of N-linked glycans on human glypican-1."Biochemistry 50:9377-9387(2011) [PubMed] [Europe PMC] [Abstract]
  13. "Suppression of amyloid beta A11 antibody immunoreactivity by vitamin C: possible role of heparan sulfate oligosaccharides derived from glypican-1 by ascorbate-induced, nitric oxide (NO)-catalyzed degradation."J. Biol. Chem. 286:27559-27572(2011) [PubMed] [Europe PMC] [Abstract]
  14. "Crystal structure of N-glycosylated human glypican-1 core protein: Structure of two loops evolutionarily conserved in vertebrate glypican-1."J. Biol. Chem. 287:14040-14051(2012) [PubMed] [Europe PMC] [Abstract]
  15. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]