12-Hydroxyeicosatetraenoic Acid (12-HETE)[Edit]
12-Hydroxyeicosatetraenoic acid (12-HETE) is an eicosanoid. It is a metabolite of arachidonic acid produced by the action of the enzyme arachidonate 12-lipoxygenase. 12-HETE is a highly selective ligand used to label mu opioid receptors. 12-HETE can activate Cdc42, Rac1 and PI-3K, which then participate as upstream signalling molecules for PAK1 and JNK1 activation. 12-Hydroxyeicosatetraenoic acid (12-HETE) is a chemotactic stimulus for epidermal cells. 12-hydroxyeicosatetraenoic acid (12-HETE), the main eicosanoid in skin, is assumed to have both pathophysiologic effects in inflammatory skin diseases such as psoriasis and atopic eczema and a physiologic role in the biology of cutaneous reparative processes. The modulation of epidermal 12-HETE receptors by UV-B may partly explain the therapeutic effects of UV-B, but possibly also contribute to photodamage to skin.
Organism species: Pan-species (General)
|CATALOG NO.||PRODUCT NAME||APPLICATIONS|
|Proteins||n/a||Complete Antigen of 12-Hydroxyeicosatetraenoic Acid (12-HETE)||Antigenic Transformation Customized Service Offer|
|Antibodies||n/a||Monoclonal Antibody to 12-Hydroxyeicosatetraenoic Acid (12-HETE)||Monoclonal Antibody Customized Service Offer|
|n/a||Polyclonal Antibody to 12-Hydroxyeicosatetraenoic Acid (12-HETE)||Polyclonal Antibody Customized Service Offer|
|Assay Kits||CEB002Ge||ELISA Kit for 12-Hydroxyeicosatetraenoic Acid (12-HETE)||Enzyme-linked immunosorbent assay for Antigen Detection.|