Acid Phosphatase 1 (ACP1)

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HAAP; Low Molecular Weight Phosphotyrosine Protein Phosphatase; Adipocyte acid phosphatase; Red cell acid phosphatase 1; LMW-PTPase

Acid Phosphatase 1 (ACP1)

Low molecular weight phosphotyrosine protein phosphatase  belongs to the phosphotyrosine protein phosphatase family of proteins. It functions as an acid phosphatase and a protein tyrosine phosphatase by hydrolyzing protein tyrosine phosphate to protein tyrosine and orthophosphate. This enzyme also hydrolyzes orthophosphoric monoesters to alcohol and orthophosphate.

This gene is genetically polymorphic, and three common alleles segregating at the corresponding locus give rise to six phenotypes. Each allele appears to encode at least two electrophoretically different isozymes, Bf and Bs, which are produced in allele-specific ratios. Three transcript variants encoding distinct isoforms have been identified for this gene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA994Hu01 Recombinant Acid Phosphatase 1 (ACP1) Positive Control; Immunogen; SDS-PAGE; WB.
RPA994Hu02 Recombinant Acid Phosphatase 1 (ACP1) Positive Control; Immunogen; SDS-PAGE; WB.
APA994Hu01 Active Acid Phosphatase 1 (ACP1) Cell culture; Activity Assays.
Antibodies PAA994Hu01 Polyclonal Antibody to Acid Phosphatase 1 (ACP1) WB; IHC; ICC; IP.
PAA994Hu02 Polyclonal Antibody to Acid Phosphatase 1 (ACP1) WB; IHC; ICC; IP.
LAA994Hu71 Biotin-Linked Polyclonal Antibody to Acid Phosphatase 1 (ACP1) WB; IHC; ICC.
LAA994Hu81 FITC-Linked Polyclonal Antibody to Acid Phosphatase 1 (ACP1) WB; IHC; ICC; IF.
MAA994Hu21 Monoclonal Antibody to Acid Phosphatase 1 (ACP1) WB
MAA994Hu22 Monoclonal Antibody to Acid Phosphatase 1 (ACP1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Acid Phosphatase 1 (ACP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Acid Phosphatase 1 (ACP1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA994Mu01 Recombinant Acid Phosphatase 1 (ACP1) Positive Control; Immunogen; SDS-PAGE; WB.
RPA994Mu02 Recombinant Acid Phosphatase 1 (ACP1) Positive Control; Immunogen; SDS-PAGE; WB.
APA994Mu02 Active Acid Phosphatase 1 (ACP1) Cell culture; Activity Assays.
Antibodies n/a Monoclonal Antibody to Acid Phosphatase 1 (ACP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Acid Phosphatase 1 (ACP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Acid Phosphatase 1 (ACP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Acid Phosphatase 1 (ACP1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA994Ra01 Recombinant Acid Phosphatase 1 (ACP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA994Ra01 Polyclonal Antibody to Acid Phosphatase 1 (ACP1) WB,IHC,ICC/IF
LAA994Ra71 Biotin-Linked Polyclonal Antibody to Acid Phosphatase 1 (ACP1) WB; IHC; ICC.
LAA994Ra81 FITC-Linked Polyclonal Antibody to Acid Phosphatase 1 (ACP1) WB; IHC; ICC; IF.
Assay Kits n/a CLIA Kit for Acid Phosphatase 1 (ACP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Acid Phosphatase 1 (ACP1) ELISA Kit Customized Service Offer
  1. "Human red cell acid phosphatase (ACP1). The amino acid sequence of the two isozymes Bf and Bs encoded by the ACP1*B allele."J. Biol. Chem. 266:20619-20625(1991) [PubMed] [Europe PMC] [Abstract]
  2. "Human red cell acid phosphatase (ACP1): the primary structure of the two pairs of isozymes encoded by the ACP1*A and ACP1*C alleles."Biochim. Biophys. Acta 1121:261-268(1992) [PubMed] [Europe PMC] [Abstract]
  3. "Sequencing, cloning, and expression of human red cell-type acid phosphatase, a cytoplasmic phosphotyrosyl protein phosphatase."J. Biol. Chem. 267:10856-10865(1992) [PubMed] [Europe PMC] [Abstract]
  4. "Gene structure, sequence, and chromosomal localization of the human red cell-type low-molecular-weight acid phosphotyrosyl phosphatase gene, ACP1."Genomics 30:133-140(1995) [PubMed] [Europe PMC] [Abstract]
  5. "Identification of the adipocyte acid phosphatase as a PAO-sensitive tyrosyl phosphatase."Protein Sci. 1:710-721(1992) [PubMed] [Europe PMC] [Abstract]
  6. "Regulation of the low molecular weight phosphotyrosine phosphatase by phosphorylation at tyrosines 131 and 132."J. Biol. Chem. 272:5371-5374(1997) [PubMed] [Europe PMC] [Abstract]
  7. "A novel isoform of the low molecular weight phosphotyrosine phosphatase, LMPTP-C, arising from alternative mRNA splicing."Eur. J. Biochem. 262:277-282(1999) [PubMed] [Europe PMC] [Abstract]
  8. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes." Genome Res. 16:55-65(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  11. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  12. , Submitted (MAR-2007) to UniProtKB
  13. "A TaqI site identifies the *A allele at the ACP1 locus."Hum. Mol. Genet. 2:1079-1079(1993) [PubMed] [Europe PMC] [Abstract]
  14. "Eph receptors discriminate specific ligand oligomers to determine alternative signaling complexes, attachment, and assembly responses."Genes Dev. 12:667-678(1998) [PubMed] [Europe PMC] [Abstract]
  15. "Regulation of the EphA2 kinase by the low molecular weight tyrosine phosphatase induces transformation."J. Biol. Chem. 277:39274-39279(2002) [PubMed] [Europe PMC] [Abstract]
  16. "Tyrosine phosphorylation regulates alpha II spectrin cleavage by calpain."Mol. Cell. Biol. 22:3527-3536(2002) [PubMed] [Europe PMC] [Abstract]
  17. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  18. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  19. "Crystal structure of a human low molecular weight phosphotyrosyl phosphatase. Implications for substrate specificity."J. Biol. Chem. 273:21714-21720(1998) [PubMed] [Europe PMC] [Abstract]