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Protein Tyrosine Phosphatase Receptor Type N (PTPRN)

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ICA3; PTPR-N; IA-2/PTP; IA2; ICA512; R-PTP-N; Islet cell antigen 512; Islet cell autoantigen 3; PTP IA-2

Protein Tyrosine Phosphatase Receptor Type N (PTPRN)
CCC A954
HGNC 9676
MGI 102765
PubMed 9828138
RGD 620777
UniProt Q16849
Wiki PTPRN

Receptor-type tyrosine-protein phosphatase-like N is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation.

This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA954Hu01 Recombinant Protein Tyrosine Phosphatase Receptor Type N (PTPRN) Positive Control; Immunogen; SDS-PAGE; WB.
RPA954Hu02 Recombinant Protein Tyrosine Phosphatase Receptor Type N (PTPRN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA954Hu01 Polyclonal Antibody to Protein Tyrosine Phosphatase Receptor Type N (PTPRN) WB; ICC; IHC-P; IHC-F; ELISA.
PAA954Hu02 Polyclonal Antibody to Protein Tyrosine Phosphatase Receptor Type N (PTPRN) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Protein Tyrosine Phosphatase Receptor Type N (PTPRN) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Tyrosine Phosphatase Receptor Type N (PTPRN) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Tyrosine Phosphatase Receptor Type N (PTPRN) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Tyrosine Phosphatase Receptor Type N (PTPRN) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Tyrosine Phosphatase Receptor Type N (PTPRN) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Tyrosine Phosphatase Receptor Type N (PTPRN) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Tyrosine Phosphatase Receptor Type N (PTPRN) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Tyrosine Phosphatase Receptor Type N (PTPRN) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Tyrosine Phosphatase Receptor Type N (PTPRN) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Tyrosine Phosphatase Receptor Type N (PTPRN) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Tyrosine Phosphatase Receptor Type N (PTPRN) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Tyrosine Phosphatase Receptor Type N (PTPRN) ELISA Kit Customized Service Offer
  1. "Molecular cloning and identification of a receptor-type protein tyrosine phosphatase, IA-2, from human insulinoma."DNA Cell Biol. 13:505-514(1994) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Islet cell antigen 512 is a diabetes-specific islet autoantigen related to protein tyrosine phosphatases."J. Immunol. 152:3183-3188(1994) [PubMed] [Europe PMC] [Abstract]
  6. "ICA 512, an autoantigen of type I diabetes, is an intrinsic membrane protein of neurosecretory granules."EMBO J. 15:2102-2114(1996) [PubMed] [Europe PMC] [Abstract]
  7. "Dephosphorylation of beta2-syntrophin and Ca2+/mu-calpain-mediated cleavage of ICA512 upon stimulation of insulin secretion."EMBO J. 20:4013-4023(2001) [PubMed] [Europe PMC] [Abstract]
  8. "Human urinary glycoproteomics; attachment site specific analysis of N-and O-linked glycosylations by CID and ECD."Mol. Cell. Proteomics 0:0-0(2011) [PubMed] [Europe PMC] [Abstract]
  9. "LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins."J. Proteome Res. 12:573-584(2013) [PubMed] [Europe PMC] [Abstract]
  10. "Structure of the mature ectodomain of the human receptor-type protein-tyrosine phosphatase IA-2."J. Biol. Chem. 283:4674-4681(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Structural genomics of protein phosphatases." J. Struct. Funct. Genomics 8:121-140(2007) [PubMed] [Europe PMC] [Abstract]