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Podocin (PDCN)

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NPHS2; NPHS-2; Nephrosis 2; Idiopathic Steroid-Resistant

Podocin (PDCN)
CCC A938
HGNC 13394
MGI 2157018
PubMed 11733557
RGD 620461
UniProt Q9NP85
Wiki Podocin

Podocin is a protein which lines the podocytes and assists in maintaining the barrier at the glomerular basement membrane.NPHS2 encodes the glomerular protein podocin which plays a role in the regulation of glomerular permeability, and acts as a linker between the plasma membrane and the cytoskeleton. Defects in this gene are the cause of autosomal recessive steroid-resistant nephrotic syndrome (SRN).

SRN is characterized by onset between three months and five years, resistance to steroid therapy and rapid progression to end-stage renal disease. An alternative splice variant has been described but its full length sequence has not been determined.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA938Hu01 Recombinant Podocin (PDCN) Positive Control; Immunogen; SDS-PAGE; WB.
RPA938Hu02 Recombinant Podocin (PDCN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA938Hu01 Polyclonal Antibody to Podocin (PDCN) WB; IHC; ICC; IP.
MAA938Hu22 Monoclonal Antibody to Podocin (PDCN) WB
LAA938Hu81 FITC-Linked Polyclonal Antibody to Podocin (PDCN) WB; IHC; ICC; IF.
LAA938Hu71 Biotin-Linked Polyclonal Antibody to Podocin (PDCN) WB; IHC; ICC.
MAA938Hu21 Monoclonal Antibody to Podocin (PDCN) WB; IHC; ICC; IP.
MAA938Hu23 Monoclonal Antibody to Podocin (PDCN) WB
Assay Kits SEA938Hu ELISA Kit for Podocin (PDCN) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA938Mu01 Recombinant Podocin (PDCN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA938Mu01 Polyclonal Antibody to Podocin (PDCN) WB; IHC; ICC; IP.
LAA938Mu71 Biotin-Linked Polyclonal Antibody to Podocin (PDCN) WB; IHC; ICC.
Assay Kits SEA938Mu ELISA Kit for Podocin (PDCN) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA938Ra01 Recombinant Podocin (PDCN) Positive Control; Immunogen; SDS-PAGE; WB.
RPA938Ra02 Recombinant Podocin (PDCN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA938Ra01 Polyclonal Antibody to Podocin (PDCN) WB; IHC; ICC; IP.
PAA938Ra02 Polyclonal Antibody to Podocin (PDCN) WB; IHC; ICC; IP.
LAA938Ra71 Biotin-Linked Polyclonal Antibody to Podocin (PDCN) WB; IHC; ICC.
Assay Kits SEA938Ra ELISA Kit for Podocin (PDCN) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "NPHS2, encoding the glomerular protein podocin, is mutated in autosomal recessive steroid-resistant nephrotic syndrome."Nat. Genet. 24:349-354(2000) [PubMed] [Europe PMC] [Abstract]
  2. ErratumNat. Genet. 25:125-125(2000) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Interaction with podocin facilitates nephrin signaling."J. Biol. Chem. 276:41543-41546(2001) [PubMed] [Europe PMC] [Abstract]
  6. "Characterization of a short isoform of the kidney protein podocin in human kidney."BMC Nephrol. 14:102-102(2013) [PubMed] [Europe PMC] [Abstract]
  7. "NPHS2 mutations in late-onset focal segmental glomerulosclerosis: R229Q is a common disease-associated allele."J. Clin. Invest. 110:1659-1666(2002) [PubMed] [Europe PMC] [Abstract]
  8. "NPHS2 mutations in sporadic steroid-resistant nephrotic syndrome in Japanese children."Pediatr. Nephrol. 18:412-416(2003) [PubMed] [Europe PMC] [Abstract]
  9. "NPHS2 mutation analysis shows genetic heterogeneity of steroid-resistant nephrotic syndrome and low post-transplant recurrence."Kidney Int. 66:571-579(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Identification of podocin (NPHS2) gene mutations in African Americans with nondiabetic end-stage renal disease."Kidney Int. 68:256-262(2005) [PubMed] [Europe PMC] [Abstract]
  11. "NPHS2 (podicin) mutations in Turkish children with idiopathic nephrotic syndrome."Pediatr. Nephrol. 22:2031-2040(2007) [PubMed] [Europe PMC] [Abstract]
  12. "Disruption of PTPRO causes childhood-onset nephrotic syndrome."Am. J. Hum. Genet. 89:139-147(2011) [PubMed] [Europe PMC] [Abstract]
  13. "Clinical value of NPHS2 analysis in early- and adult-onset steroid-resistant nephrotic syndrome." Clin. J. Am. Soc. Nephrol. 6:344-354(2011) [PubMed] [Europe PMC] [Abstract]
  14. "Mutational analysis of the NPHS2 gene in Czech patients with idiopathic nephrotic syndrome."Folia Biol. (Praha) 58:64-68(2012) [PubMed] [Europe PMC] [Abstract]
  15. "A spectrum of novel NPHS1 and NPHS2 gene mutations in pediatric nephrotic syndrome patients from Pakistan."Gene 502:133-137(2012) [PubMed] [Europe PMC] [Abstract]
  16. "Mutations in NPHS2 (podocin) in Mexican children with nephrotic syndrome who respond to standard steroid treatment."Genet. Mol. Res. 12:2102-2107(2013) [PubMed] [Europe PMC] [Abstract]
  17. "NPHS2 gene in steroid-resistant nephrotic syndrome: prevalence, clinical course, and mutational spectrum in South-West Iranian children."Iran. J. Kidney Dis. 7:357-362(2013) [PubMed] [Europe PMC] [Abstract]
  18. "NPHS2 p.V290M mutation in late-onset steroid-resistant nephrotic syndrome."Pediatr. Nephrol. 28:751-757(2013) [PubMed] [Europe PMC] [Abstract]
  19. "NPHS2 homozygous p.R229Q variant: potential modifier instead of causal effect in focal segmental glomerulosclerosis."Pediatr. Nephrol. 28:2061-2064(2013) [PubMed] [Europe PMC] [Abstract]
  20. "NPHS2 mutations in steroid-resistant nephrotic syndrome: a mutation update and the associated phenotypic spectrum." Hum. Mutat. 35:178-186(2014) [PubMed] [Europe PMC] [Abstract]
  21. "Mutation-dependent recessive inheritance of NPHS2-associated steroid-resistant nephrotic syndrome."Nat. Genet. 46:299-304(2014) [PubMed] [Europe PMC] [Abstract]