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Arachidonate-15-Lipoxygenase (ALOX15)

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LOX15; 15-LOX2; 15-LOX1; 15-LOX; 12-LOX; ALOX15; 15-LO; 15-LPG; LOG15; Lipoxygenase 15; Arachidonate 12-lipoxygenase, leukocyte-type; Arachidonate omega-6 lipoxygenase

Arachidonate-15-Lipoxygenase (ALOX15)
CCC A891
HGNC 433
MGI 87997
PubMed 14716014
RGD 70493
UniProt P16050
Wiki ALOX15

Yoshimoto et al. (1990) found that the amino acid sequence of human reticulocyte 15-lipoxygenase (Sigal et al., 1988) showed 86% identity with that of porcine leukocyte 12-lipoxygenase. Sigal et al. (1988) found 61% sequence similarity between 15-lipoxygenase and 5-lipoxygenase. This suggests that in the human 12-lipoxygenase is more closely related evolutionarily to 15-lipoxygenase than to 5-lipoxygenase, even though the comparisons are made between human and porcine enzymes. By PCR analysis of a human-hamster somatic hybrid DNA panel, Funk et al. (1992) demonstrated that genes for 12-lipoxygenase and 15-lipoxygenase are located on human chromosome 17, whereas the most unrelated lipoxygenase (5-lipoxygenase) was mapped to chromosome 10.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA891Hu01 Recombinant Arachidonate-15-Lipoxygenase (ALOX15) Positive Control; Immunogen; SDS-PAGE; WB.
RPA891Hu02 Recombinant Arachidonate-15-Lipoxygenase (ALOX15) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA891Hu01 Polyclonal Antibody to Arachidonate-15-Lipoxygenase (ALOX15) WB; IHC; ICC; IP.
LAA891Hu71 Biotin-Linked Polyclonal Antibody to Arachidonate-15-Lipoxygenase (ALOX15) WB; IHC; ICC.
LAA891Hu81 FITC-Linked Polyclonal Antibody to Arachidonate-15-Lipoxygenase (ALOX15) WB; IHC; ICC; IF.
MAA891Hu21 Monoclonal Antibody to Arachidonate-15-Lipoxygenase (ALOX15) WB
PAA891Hu02 Polyclonal Antibody to Arachidonate-15-Lipoxygenase (ALOX15) WB; IHC; ICC; IP.
MAA891Hu22 Monoclonal Antibody to Arachidonate-15-Lipoxygenase (ALOX15) WB; IHC; ICC; IP.
MAA891Hu23 Monoclonal Antibody to Arachidonate-15-Lipoxygenase (ALOX15) WB; IHC; ICC; IP.
Assay Kits SEA891Hu ELISA Kit for Arachidonate-15-Lipoxygenase (ALOX15) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Arachidonate-15-Lipoxygenase (ALOX15) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Arachidonate-15-Lipoxygenase (ALOX15) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Arachidonate-15-Lipoxygenase (ALOX15) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Arachidonate-15-Lipoxygenase (ALOX15) CLIA Kit Customized Service Offer
n/a ELISA Kit for Arachidonate-15-Lipoxygenase (ALOX15) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Arachidonate-15-Lipoxygenase (ALOX15) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Arachidonate-15-Lipoxygenase (ALOX15) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Arachidonate-15-Lipoxygenase (ALOX15) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Arachidonate-15-Lipoxygenase (ALOX15) CLIA Kit Customized Service Offer
n/a ELISA Kit for Arachidonate-15-Lipoxygenase (ALOX15) ELISA Kit Customized Service Offer
  1. "Molecular cloning and primary structure of human 15-lipoxygenase."Biochem. Biophys. Res. Commun. 157:457-464(1988) [PubMed] [Europe PMC] [Abstract]
  2. "Characterization and sequence of an additional 15-lipoxygenase transcript and of the human gene."Biochim. Biophys. Acta 1352:267-281(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Human 15-lipoxygenase gene promoter: analysis and identification of DNA binding sites for IL-13-induced regulatory factors in monocytes."Mol. Biol. Rep. 25:173-182(1998) [PubMed] [Europe PMC] [Abstract]
  7. "Arachidonate 15-lipoxygenase (omega-6 lipoxygenase) from human leukocytes. Purification and structural homology to other mammalian lipoxygenases."J. Biol. Chem. 263:5328-5332(1988) [PubMed] [Europe PMC] [Abstract]
  8. "Purification of two forms of arachidonate 15-lipoxygenase from human leukocytes."Eur. J. Biochem. 202:1231-1238(1991) [PubMed] [Europe PMC] [Abstract]
  9. "A primary determinant for lipoxygenase positional specificity."Nature 354:149-152(1991) [PubMed] [Europe PMC] [Abstract]
  10. "Membrane translocation of 15-lipoxygenase in hematopoietic cells is calcium-dependent and activates the oxygenase activity of the enzyme."Blood 91:64-74(1998) [PubMed] [Europe PMC] [Abstract]
  11. "Evaluation of the activity and localization of 15-lipoxygenase-1 after introduction into human colorectal carcinoma Caco-2 cells."Prostaglandins Leukot. Essent. Fatty Acids 64:217-225(2001) [PubMed] [Europe PMC] [Abstract]
  12. "Interaction of human 15-lipoxygenase-1 with phosphatidylinositol bisphosphates results in increased enzyme activity."Biochim. Biophys. Acta 1761:1498-1505(2006) [PubMed] [Europe PMC] [Abstract]
  13. "Reciprocal regulation of 12- and 15-lipoxygenases by UV-irradiation in human keratinocytes."FEBS Lett. 582:3249-3253(2008) [PubMed] [Europe PMC] [Abstract]
  14. "15(S)-Lipoxygenase-1 associates with neutral lipid droplets in macrophage foam cells: evidence of lipid droplet metabolism."J. Lipid Res. 50:2371-2376(2009) [PubMed] [Europe PMC] [Abstract]
  15. "15-Lipoxygenase 1 interacts with phosphatidylethanolamine-binding protein to regulate MAPK signaling in human airway epithelial cells."Proc. Natl. Acad. Sci. U.S.A. 108:14246-14251(2011) [PubMed] [Europe PMC] [Abstract]
  16. "A near null variant of 12/15-LOX encoded by a novel SNP in ALOX15 and the risk of coronary artery disease."Atherosclerosis 198:136-144(2008) [PubMed] [Europe PMC] [Abstract]