Renin (REN)

Renin is a member of the aspartyl proteinase family produced largely in part by the juxtaglomerular cells in the kidney.Renin differs from the other members of this class by having a pH optimum near neutral pH region with native substrates instead of 2.0 to 3.4 This more neutral pH optimum allows it to be functional in the plasma.

Renin also has very high selectivity for substrate due to quite long peptide recognition on either side of the peptide bond undergoing cleavage. An octapeptide substrate was the minimum length to be cleaved by renin. Renin plays a crucial role in the regulation of blood pressure and salt balance through the cleavage of angiotensinogen, which is the only known physiological substrate of renin.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA889Hu01 Recombinant Renin (REN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA889Hu01 Polyclonal Antibody to Renin (REN) WB; IHC; ICC; IP.
MAA889Hu22 Monoclonal Antibody to Renin (REN) WB; IHC; ICC; IP.
Assay Kits SEA889Hu ELISA Kit for Renin (REN) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA889Hu CLIA Kit for Renin (REN) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA889Mu01 Recombinant Renin (REN) Positive Control; Immunogen; SDS-PAGE; WB.
RPA889Mu02 Recombinant Renin (REN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA889Mu01 Polyclonal Antibody to Renin (REN) WB; IHC; ICC; IP.
PAA889Mu02 Polyclonal Antibody to Renin (REN) WB; IHC; ICC; IP.
LAA889Mu71 Biotin-Linked Polyclonal Antibody to Renin (REN) WB; IHC; ICC.
Assay Kits SEA889Mu ELISA Kit for Renin (REN) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA889Ra01 Recombinant Renin (REN) Positive Control; Immunogen; SDS-PAGE; WB.
RPA889Ra02 Recombinant Renin (REN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA889Ra01 Polyclonal Antibody to Renin (REN) WB; IHC; ICC; IP.
PAA889Ra02 Polyclonal Antibody to Renin (REN) WB; IHC; ICC; IP.
LAA889Ra71 Biotin-Linked Polyclonal Antibody to Renin (REN) WB; IHC; ICC.
MAA889Ra21 Monoclonal Antibody to Renin (REN) WB; IHC; ICC; IP.
Assay Kits SEA889Ra ELISA Kit for Renin (REN) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA889Rb01 Recombinant Renin (REN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA889Rb51 Polyclonal Antibody to Renin (REN) WB; IHC; ICC; IP.
MAA889Rb21 Monoclonal Antibody to Renin (REN) WB; IHC; ICC; IP.
Assay Kits SEA889Rb ELISA Kit for Renin (REN) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Canis familiaris; Canine (Dog)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA889Ca01 Recombinant Renin (REN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA889Ca01 Polyclonal Antibody to Renin (REN) WB; IHC; ICC; IP.
MAA889Ca21 Monoclonal Antibody to Renin (REN) WB; IHC; ICC; IP.
Assay Kits SEA889Ca ELISA Kit for Renin (REN) Enzyme-linked immunosorbent assay for Antigen Detection.
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  9. "Segmental homology between the promoter region of the human renin gene and the mouse ren1 and ren2 promoter regions."Gene 41:85-92(1986) [PubMed] [Europe PMC] [Abstract]
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  13. "X-ray analyses of peptide-inhibitor complexes define the structural basis of specificity for human and mouse renins."Nature 357:466-472(1992) [PubMed] [Europe PMC] [Abstract]
  14. "A redox switch in angiotensinogen modulates angiotensin release."Nature 468:108-111(2010) [PubMed] [Europe PMC] [Abstract]
  15. "Mutations in genes in the renin-angiotensin system are associated with autosomal recessive renal tubular dysgenesis."Nat. Genet. 37:964-968(2005) [PubMed] [Europe PMC] [Abstract]
  16. "Dominant renin gene mutations associated with early-onset hyperuricemia, anemia, and chronic kidney failure." Am. J. Hum. Genet. 85:204-213(2009) [PubMed] [Europe PMC] [Abstract]