Podocalyxin (PODXL)

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Gp200; PCLP; PC; PCX; Podocalyxin Like Protein 1; GCTM-2 antigen

Podocalyxin (PODXL)

Podocalyxin belongs to the CD34/Podocalyxin family of sialomucins that share structural similarity and sequence homology. Podocalyxin is a major sialoprotein in the podocytes of the kidney glomerulus and is also expressed by both endothelium and multipotent hematopoietic progenitors. It has been identified as a novel cell surface marker for hemangioblasts, the common precursors of hematopoietic and endothelial cells.The  protein was originally identified as an important component of glomerular podocytes. Other biological activities of the encoded protein include: binding in a membrane protein complex with Na+/H+ exchanger regulatory factor to intracellular cytoskeletal elements, playing a role in hematopoetic cell differentiation, and being expressed in vascular endothelium cells and binding to L-selectin.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA768Hu01 Recombinant Podocalyxin (PODXL) Positive Control; Immunogen; SDS-PAGE; WB.
RPA768Hu02 Recombinant Podocalyxin (PODXL) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA768Hu01 Polyclonal Antibody to Podocalyxin (PODXL) WB; IHC; ICC; IP.
MAA768Hu22 Monoclonal Antibody to Podocalyxin (PODXL) WB; IHC; ICC; IP.
LAA768Hu71 Biotin-Linked Polyclonal Antibody to Podocalyxin (PODXL) WB; IHC; ICC.
Assay Kits SEA768Hu ELISA Kit for Podocalyxin (PODXL) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA768Mu01 Recombinant Podocalyxin (PODXL) Positive Control; Immunogen; SDS-PAGE; WB.
RPA768Mu02 Recombinant Podocalyxin (PODXL) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA768Mu01 Polyclonal Antibody to Podocalyxin (PODXL) WB; IHC; ICC; IP.
PAA768Mu02 Polyclonal Antibody to Podocalyxin (PODXL) WB; IHC; ICC; IP.
Assay Kits SEA768Mu ELISA Kit for Podocalyxin (PODXL) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA768Ra01 Recombinant Podocalyxin (PODXL) Positive Control; Immunogen; SDS-PAGE; WB.
RPA768Ra02 Recombinant Podocalyxin (PODXL) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA768Ra01 Polyclonal Antibody to Podocalyxin (PODXL) WB; IHC; ICC; IP.
MAA768Ra21 Monoclonal Antibody to Podocalyxin (PODXL) WB; IHC; ICC; IP.
PAA768Ra02 Polyclonal Antibody to Podocalyxin (PODXL) WB; IHC; ICC; IP.
Assay Kits SEA768Ra ELISA Kit for Podocalyxin (PODXL) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Molecular cloning and characterization of human podocalyxin-like protein. Orthologous relationship to rabbit PCLP1 and rat podocalyxin."J. Biol. Chem. 272:15708-15714(1997) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
  3. "Human chromosome 7: DNA sequence and biology." Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Human embryonal carcinoma tumor antigen, Gp200/GCTM-2, is podocalyxin."Biochem. Biophys. Res. Commun. 300:285-290(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Podocalyxin increases the aggressive phenotype of breast and prostate cancer cells in vitro through its interaction with ezrin."Cancer Res. 67:6183-6191(2007) [PubMed] [Europe PMC] [Abstract]
  7. "Expression of podocalyxin enhances the adherence, migration, and intercellular communication of cells."Exp. Cell Res. 314:2004-2015(2008) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]