Fibroblast Growth Factor 23 (FGF23)

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ADHR; HYPF; HPDR2; PHPTC; Phosphatonin; Tumor-derived hypophosphatemia-inducing factor

Fibroblast Growth Factor 23 (FGF23)

FGF23 is located on chromosome 12 and is composed of three exons. Mutations in FGF23 that render the protein resistant to proteolytic cleavage leads to increased activity of FGF23 and the renal phosphate loss found in the human disease autosomal dominant hypophosphatemic rickets. FGF23 is also overproduced by some types of tumors, causing tumor-produced osteomalacia. Loss of FGF23 activity is thought to lead to increased phosphate levels and the clinical syndrome of familial tumor calcinosis. This gene was identified by its mutations associated with autosomal dominant hypophosphatemic rickets. Prior to discovery in 2000, it was hypothesized that a protein existed which performed the function of FGF23. This putative protein was known as phosphatonin.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA746Hu01 Recombinant Fibroblast Growth Factor 23 (FGF23) Positive Control; Immunogen; SDS-PAGE; WB.
RPA746Hu02 Recombinant Fibroblast Growth Factor 23 (FGF23) Positive Control; Immunogen; SDS-PAGE; WB.
RPA746Hu03 Recombinant Fibroblast Growth Factor 23 (FGF23) Positive Control; Immunogen; SDS-PAGE; WB.
APA746Hu01 Active Fibroblast Growth Factor 23 (FGF23) Cell culture; Activity Assays.
RPA746Hu04 Recombinant Fibroblast Growth Factor 23 (FGF23) Positive Control; Immunogen; SDS-PAGE; WB.
APA746Hu03 Active Fibroblast Growth Factor 23 (FGF23) Cell culture; Activity Assays.
Antibodies PAA746Hu01 Polyclonal Antibody to Fibroblast Growth Factor 23 (FGF23) WB; IHC; ICC; IP.
MAA746Hu22 Monoclonal Antibody to Fibroblast Growth Factor 23 (FGF23) WB; IHC; ICC; IP.
PAA746Hu02 Polyclonal Antibody to Fibroblast Growth Factor 23 (FGF23) WB; IHC; ICC; IP.
PAA746Hu03 Polyclonal Antibody to Fibroblast Growth Factor 23 (FGF23) WB; IHC; ICC; IP.
LAA746Hu71 Biotin-Linked Polyclonal Antibody to Fibroblast Growth Factor 23 (FGF23) WB; IHC; ICC.
LAA746Hu72 Biotin-Linked Monoclonal Antibody to Fibroblast Growth Factor 23 (FGF23) WB; IHC; ICC.
PAA746Hu04 Polyclonal Antibody to Fibroblast Growth Factor 23 (FGF23) WB; IHC; ICC; IP.
Assay Kits SEA746Hu ELISA Kit for Fibroblast Growth Factor 23 (FGF23) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA746Mu01 Recombinant Fibroblast Growth Factor 23 (FGF23) Positive Control; Immunogen; SDS-PAGE; WB.
RPA746Mu02 Recombinant Fibroblast Growth Factor 23 (FGF23) Positive Control; Immunogen; SDS-PAGE; WB.
APA746Mu01 Active Fibroblast Growth Factor 23 (FGF23) Cell culture; Activity Assays.
Antibodies PAA746Mu01 Polyclonal Antibody to Fibroblast Growth Factor 23 (FGF23) WB; IHC; ICC; IP.
PAA746Mu02 Polyclonal Antibody to Fibroblast Growth Factor 23 (FGF23) WB; IHC; ICC; IP.
Assay Kits SEA746Mu ELISA Kit for Fibroblast Growth Factor 23 (FGF23) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA746Ra01 Recombinant Fibroblast Growth Factor 23 (FGF23) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA746Ra01 Polyclonal Antibody to Fibroblast Growth Factor 23 (FGF23) WB; IHC; ICC; IP.
MAA746Ra21 Monoclonal Antibody to Fibroblast Growth Factor 23 (FGF23) WB; IHC; ICC; IP.
Assay Kits CEA746Ra ELISA Kit for Fibroblast Growth Factor 23 (FGF23) Enzyme-linked immunosorbent assay for Antigen Detection.
SEA746Ra ELISA Kit for Fibroblast Growth Factor 23 (FGF23) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Identification of a novel fibroblast growth factor, FGF-23, preferentially expressed in the ventrolateral thalamic nucleus of the brain."Biochem. Biophys. Res. Commun. 277:494-498(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23."Nat. Genet. 26:345-348(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Cloning and characterization of FGF23 as a causative factor of tumor-induced osteomalacia."Proc. Natl. Acad. Sci. U.S.A. 98:6500-6505(2001) [PubMed] [Europe PMC] [Abstract]
  4. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
  7. "FGF-23 inhibits renal tubular phosphate transport and is a PHEX substrate."Biochem. Biophys. Res. Commun. 284:977-981(2001) [PubMed] [Europe PMC] [Abstract]
  8. "The autosomal dominant hypophosphatemic rickets (ADHR) gene is a secreted polypeptide overexpressed by tumors that cause phosphate wasting."J. Clin. Endocrinol. Metab. 86:497-500(2001) [PubMed] [Europe PMC] [Abstract]
  9. "Mutant FGF-23 responsible for autosomal dominant hypophosphatemic rickets is resistant to proteolytic cleavage and causes hypophosphatemia in vivo."Endocrinology 143:3179-3182(2002) [PubMed] [Europe PMC] [Abstract]
  10. "FGF-23 in fibrous dysplasia of bone and its relationship to renal phosphate wasting."J. Clin. Invest. 112:683-692(2003) [PubMed] [Europe PMC] [Abstract]
  11. "FGF23 is processed by proprotein convertases but not by PHEX."Bone 35:455-462(2004) [PubMed] [Europe PMC] [Abstract]
  12. "FGF-23 is a potent regulator of vitamin D metabolism and phosphate homeostasis."J. Bone Miner. Res. 19:429-435(2004) [PubMed] [Europe PMC] [Abstract]
  13. "Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family."J. Biol. Chem. 281:15694-15700(2006) [PubMed] [Europe PMC] [Abstract]
  14. "Polypeptide GalNAc-transferase T3 and familial tumoral calcinosis. Secretion of fibroblast growth factor 23 requires O-glycosylation."J. Biol. Chem. 281:18370-18377(2006) [PubMed] [Europe PMC] [Abstract]
  15. "Overexpression of fibroblast growth factor 23 suppresses osteoblast differentiation and matrix mineralization in vitro."J. Bone Miner. Res. 23:939-948(2008) [PubMed] [Europe PMC] [Abstract]
  16. "Fibroblast growth factor signalling: from development to cancer."Nat. Rev. Cancer 10:116-129(2010) [PubMed] [Europe PMC] [Abstract]
  17. "Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members." Mol. Cell. Biol. 27:3417-3428(2007) [PubMed] [Europe PMC] [Abstract]
  18. "A novel homozygous missense mutation in FGF23 causes Familial Tumoral Calcinosis associated with disseminated visceral calcification."Hum. Genet. 118:261-266(2005) [PubMed] [Europe PMC] [Abstract]
  19. "An FGF23 missense mutation causes familial tumoral calcinosis with hyperphosphatemia."Hum. Mol. Genet. 14:385-390(2005) [PubMed] [Europe PMC] [Abstract]
  20. "A novel mutation in fibroblast growth factor 23 gene as a cause of tumoral calcinosis."J. Clin. Endocrinol. Metab. 90:5523-5527(2005) [PubMed] [Europe PMC] [Abstract]
  21. "A new missense mutation in FGF23 gene in a male with hyperostosis-hyperphosphatemia syndrome (HHS)."Gene 542:269-271(2014) [PubMed] [Europe PMC] [Abstract]