≡

Glucose-6-phosphate Dehydrogenase (G6PD)

[Edit]

Glucose-6-phosphate 1-dehydrogenase

Glucose-6-phosphate Dehydrogenase (G6PD)
CCC A716
HGNC 4057
MGI 105979
PubMed 7949118
RGD 2645
UniProt P11413
Wiki G6PD

Glucose-6-phosphate dehydrogenase (G6PD) is a cytosolic enzyme in the pentose phosphate pathway, a metabolic pathway that supplies reducing energy to cells by maintaining the level of the co-enzyme nicotinamide adenine dinucleotide phosphate (NADPH). The NADPH in turn maintains the level of glutathione in these cells that helps protect the red blood cells against oxidative damage. Of greater quantitative importance is the production of NADPH for tissues actively engaged in biosynthesis of fatty acids and/or isoprenoids, such as the liver, mammary glands, adipose tissue, and the adrenal glands.G6PD is widely distributed in many species from bacteria to humans. In higher plants, several isoforms of G6PDH have been reported, which are localized in the cytosol, the plastidic stroma, and peroxisomes.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA716Hu01 Recombinant Glucose-6-phosphate Dehydrogenase (G6PD) Positive Control; Immunogen; SDS-PAGE; WB.
RPA716Hu02 Recombinant Glucose-6-phosphate Dehydrogenase (G6PD) Positive Control; Immunogen; SDS-PAGE; WB.
APA716Hu01 Active Glucose-6-phosphate Dehydrogenase (G6PD) Cell culture; Activity Assays.
Antibodies PAA716Hu01 Polyclonal Antibody to Glucose-6-phosphate Dehydrogenase (G6PD) WB,IHC
MAA716Hu22 Monoclonal Antibody to Glucose-6-phosphate Dehydrogenase (G6PD) WB; IHC; ICC; IP.
LAA716Hu71 Biotin-Linked Polyclonal Antibody to Glucose-6-phosphate Dehydrogenase (G6PD) WB; IHC; ICC.
PAA716Hu02 Polyclonal Antibody to Glucose-6-phosphate Dehydrogenase (G6PD) WB; IHC; ICC; IP.
Assay Kits SEA716Hu ELISA Kit for Glucose-6-phosphate Dehydrogenase (G6PD) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA716Mu01 Recombinant Glucose-6-phosphate Dehydrogenase (G6PD) Positive Control; Immunogen; SDS-PAGE; WB.
RPA716Mu02 Recombinant Glucose-6-phosphate Dehydrogenase (G6PD) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA716Mu01 Polyclonal Antibody to Glucose-6-phosphate Dehydrogenase (G6PD) WB; IHC; ICC; IP.
PAA716Mu02 Polyclonal Antibody to Glucose-6-phosphate Dehydrogenase (G6PD) WB; IHC; ICC; IP.
Assay Kits SEA716Mu ELISA Kit for Glucose-6-phosphate Dehydrogenase (G6PD) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA716Ra01 Recombinant Glucose-6-phosphate Dehydrogenase (G6PD) Positive Control; Immunogen; SDS-PAGE; WB.
CPA716Ra21 OVA Conjugated Glucose-6-phosphate Dehydrogenase (G6PD) Immunogen; SDS-PAGE; WB.
Antibodies PAA716Ra01 Polyclonal Antibody to Glucose-6-phosphate Dehydrogenase (G6PD) WB
LAA716Ra71 Biotin-Linked Polyclonal Antibody to Glucose-6-phosphate Dehydrogenase (G6PD) WB; IHC; ICC.
LAA716Ra81 FITC-Linked Polyclonal Antibody to Glucose-6-phosphate Dehydrogenase (G6PD) WB; IHC; ICC; IF.
MAA716Ra21 Monoclonal Antibody to Glucose-6-phosphate Dehydrogenase (G6PD) WB; IHC; ICC; IP.
Assay Kits SEA716Ra ELISA Kit for Glucose-6-phosphate Dehydrogenase (G6PD) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Glucose-6-phosphate Dehydrogenase (G6PD) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Glucose-6-phosphate Dehydrogenase (G6PD) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Glucose-6-phosphate Dehydrogenase (G6PD) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Glucose-6-phosphate Dehydrogenase (G6PD) CLIA Kit Customized Service Offer
n/a ELISA Kit for Glucose-6-phosphate Dehydrogenase (G6PD) ELISA Kit Customized Service Offer
  1. "Isolation of human glucose-6-phosphate dehydrogenase (G6PD) cDNA clones: primary structure of the protein and unusual 5' non-coding region."Nucleic Acids Res. 14:2511-2522(1986) [PubMed] [Europe PMC] [Abstract]
  2. "Structural analysis of the X-linked gene encoding human glucose 6-phosphate dehydrogenase."EMBO J. 5:1849-1855(1986) [PubMed] [Europe PMC] [Abstract]
  3. "Molecular cloning and nucleotide sequence of cDNA for human glucose-6-phosphate dehydrogenase variant A(-)."Proc. Natl. Acad. Sci. U.S.A. 85:3951-3954(1988) [PubMed] [Europe PMC] [Abstract]
  4. "Sequence of human glucose-6-phosphate dehydrogenase cloned in plasmids and a yeast artificial chromosome."Genomics 10:792-800(1991) [PubMed] [Europe PMC] [Abstract]
  5. "Long-range sequence analysis in Xq28: thirteen known and six candidate genes in 219.4 kb of high GC DNA between the RCP/GCP and G6PD loci."Hum. Mol. Genet. 5:659-668(1996) [PubMed] [Europe PMC] [Abstract]
  6. "The DNA sequence of the human X chromosome." Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Two structural genes on different chromosomes are required for encoding the major subunit of human red cell glucose-6-phosphate dehydrogenase."Cell 58:595-606(1989) [PubMed] [Europe PMC] [Abstract]
  9. "5' structure and expression of human glucose-6-phosphate dehydrogenase mRNA."DNA Cell Biol. 12:209-215(1993) [PubMed] [Europe PMC] [Abstract]
  10. "The CpG island in the 5' region of the G6PD gene of man and mouse."Gene 102:197-203(1991) [PubMed] [Europe PMC] [Abstract]
  11. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
  12. "A to G substitution identified in exon 2 of the G6PD gene among G6PD deficient Chinese."Nucleic Acids Res. 19:6056-6056(1991) [PubMed] [Europe PMC] [Abstract]
  13. "Nucleotide variability at G6pd and the signature of malarial selection in humans."Genetics 162:1849-1861(2002) [PubMed] [Europe PMC] [Abstract]
  14. "Human glucose-6-phosphate dehydrogenase: primary structure and cDNA cloning."Proc. Natl. Acad. Sci. U.S.A. 83:4157-4161(1986) [PubMed] [Europe PMC] [Abstract]
  15. "Human erythrocyte glucose-6-phosphate dehydrogenase. Identification of a reactive lysyl residue labelled with pyridoxal 5'-phosphate."Eur. J. Biochem. 171:485-489(1988) [PubMed] [Europe PMC] [Abstract]
  16. "Amino acid sequence of the carboxy-terminal end of human erythrocyte glucose-6-phosphate dehydrogenase."Biochem. Biophys. Res. Commun. 118:332-338(1984) [PubMed] [Europe PMC] [Abstract]
  17. "Alternative splicing of human glucose-6-phosphate dehydrogenase messenger RNA in different tissues."J. Clin. Invest. 83:343-346(1989) [PubMed] [Europe PMC] [Abstract]
  18. "Glucose 6-phosphate dehydrogenase from human erythrocytes: identification of N-acetyl-alanine at the N-terminus of the mature protein."Biochem. Biophys. Res. Commun. 207:331-338(1995) [PubMed] [Europe PMC] [Abstract]
  19. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  20. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  21. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  22. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  23. "Glucose-6-phosphate dehydrogenase, NADPH, and cell survival."IUBMB Life 64:362-369(2012) [PubMed] [Europe PMC] [Abstract]
  24. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  25. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  26. "Regulation of G6PD acetylation by KAT9/SIRT2 modulates NADPH homeostasis and cell survival during oxidative stress."EMBO J. 33:1304-1320(2014) [PubMed] [Europe PMC] [Abstract]
  27. "Human glucose-6-phosphate dehydrogenase: the crystal structure reveals a structural NADP(+) molecule and provides insights into enzyme deficiency."Structure 8:293-303(2000) [PubMed] [Europe PMC] [Abstract]
  28. "Variants of glucose-6-phosphate dehydrogenase are due to missense mutations spread throughout the coding region of the gene."Hum. Mutat. 2:159-167(1993) [PubMed] [Europe PMC] [Abstract]
  29. "G6PDdb, an integrated database of glucose-6-phosphate dehydrogenase (G6PD) mutations."Hum. Mutat. 19:217-224(2002) [PubMed] [Europe PMC] [Abstract]
  30. "Structural studies of glucose-6-phosphate and NADP+ binding to human glucose-6-phosphate dehydrogenase."Acta Crystallogr. D 61:495-504(2005) [PubMed] [Europe PMC] [Abstract]
  31. "A single nucleotide base transition is the basis of the common human glucose-6-phosphate dehydrogenase variant A (+)."Genomics 1:228-231(1987) [PubMed] [Europe PMC] [Abstract]
  32. "Diverse point mutations in the human glucose-6-phosphate dehydrogenase gene cause enzyme deficiency and mild or severe hemolytic anemia."Proc. Natl. Acad. Sci. U.S.A. 85:5171-5175(1988) [PubMed] [Europe PMC] [Abstract]
  33. "Two point mutations are responsible for G6PD polymorphism in Sardinia."Am. J. Hum. Genet. 44:233-240(1989) [PubMed] [Europe PMC] [Abstract]
  34. "New glucose-6-phosphate dehydrogenase mutations from various ethnic groups."Blood 80:255-256(1992) [PubMed] [Europe PMC] [Abstract]
  35. "Molecular basis of chronic non-spherocytic haemolytic anaemia: a new G6PD variant (393arg-to-his) with abnormal K(m) G6P and marked in vivo instability."Br. J. Haematol. 80:111-116(1992) [PubMed] [Europe PMC] [Abstract]
  36. "A novel C to T substitution at nucleotide 1360 of cDNA which abolishes a natural Hha I site accounts for a new G6PD deficiency gene in Chinese."Hum. Mol. Genet. 1:205-205(1992) [PubMed] [Europe PMC] [Abstract]
  37. "G6PD Kalyan and G6PD Kerala; two deficient variants in India caused by the same 317 Glu-->Lys mutation."Hum. Mol. Genet. 1:209-210(1992) [PubMed] [Europe PMC] [Abstract]
  38. "G6PD Aures: a new mutation (48 Ile-->Thr) causing mild G6PD deficiency is associated with favism."Hum. Mol. Genet. 2:81-82(1993) [PubMed] [Europe PMC] [Abstract]
  39. "Molecular study of eight Japanese cases of glucose-6-phosphate dehydrogenase deficiency by nonradioisotopic single-strand conformation polymorphism analysis."Blood 83:3363-3368(1994) [PubMed] [Europe PMC] [Abstract]
  40. "A novel single-base mutation in the glucose 6-phosphate dehydrogenase gene is associated with chronic non-spherocytic haemolytic anaemia."Hum. Genet. 94:560-562(1994) [PubMed] [Europe PMC] [Abstract]
  41. "Multiple glucose 6-phosphate dehydrogenase-deficient variants correlate with malaria endemicity in the Vanuatu archipelago (southwestern Pacific)."Am. J. Hum. Genet. 56:294-301(1995) [PubMed] [Europe PMC] [Abstract]
  42. "A new glucose-6-phosphate dehydrogenase variant, G6PD Orissa (44 Ala-->Gly), is the major polymorphic variant in tribal populations in India."Am. J. Hum. Genet. 57:1335-1341(1995) [PubMed] [Europe PMC] [Abstract]
  43. "New glucose-6-phosphate dehydrogenase mutations associated with chronic anemia."Blood 85:1377-1380(1995) [PubMed] [Europe PMC] [Abstract]
  44. "G6PD Mount Sinai: a new severe hemolytic variant characterized by dual mutations at nucleotides 376G and 1159T (N126D)."Hum. Mutat. Suppl. 1:S154-S155(1998) [PubMed] [Europe PMC] [Abstract]
  45. "A new glucose 6 phosphate dehydrogenase variant, G6PD Sinnai (34 G->T)."Hum. Mutat. 12:72-73(1998) [PubMed] [Europe PMC] [Abstract]
  46. "A new exon 9 glucose-6-phosphate dehydrogenase mutation (G6PD 'Rehovot') in a Jewish Ethiopian family with variable phenotypes."Blood Cells Mol. Dis. 26:567-571(2000) [PubMed] [Europe PMC] [Abstract]
  47. "Positively selected G6PD-Mahidol mutation reduces Plasmodium vivax density in Southeast Asians."Science 326:1546-1549(2009) [PubMed] [Europe PMC] [Abstract]