Mucin 5 Subtype B (MUC5B)

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MUC5-B; MUC9; MG1; Oligomeric Mucus/Gel-Forming; Mucin 5,Subtype B,Tracheobronchial; Cervical mucin; High molecular weight salivary mucin MG1; Sublingual gland mucin

Mucin 5 Subtype B (MUC5B)

Mucins are high molecular mass, highly glycosylated macromolecules that are the major components of mucus secretions. MUC5B is a salivary mucin that is thought to contribute to the lubricating and viscoelastic properties of whole saliva. It is composed of 14.9% protein, 78.1% carbohydrate, and 7% sulfate.Desseyn et al. isolated MUC5B genomic sequence. They found that the central exon encodes a predicted 3,570-amino acid peptide containing 19 subdomains that can be grouped into 4 larger composite units referred to as 'superrepeats'. Since MUC5B and the related proteins MUC2 and MUC5AC are clustered within chromosome 11p15.5, suggesting that they are members of a multigene family.Desseyn et al. reported that the region 3-prime of the large central exon of MUC5B is composed of 18 exons and spans about 10.7 kb.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA684Hu01 Recombinant Mucin 5 Subtype B (MUC5B) Positive Control; Immunogen; SDS-PAGE; WB.
CPA684Hu21 OVA Conjugated Mucin 5 Subtype B (MUC5B) Immunogen; SDS-PAGE; WB.
RPA684Hu02 Recombinant Mucin 5 Subtype B (MUC5B) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA684Hu01 Polyclonal Antibody to Mucin 5 Subtype B (MUC5B) WB; IHC; ICC; IP.
MAA684Hu22 Monoclonal Antibody to Mucin 5 Subtype B (MUC5B) WB; IHC; ICC; IP.
LAA684Hu71 Biotin-Linked Polyclonal Antibody to Mucin 5 Subtype B (MUC5B) WB; IHC; ICC.
LAA684Hu81 FITC-Linked Polyclonal Antibody to Mucin 5 Subtype B (MUC5B) WB; IHC; ICC; IF.
Assay Kits SEA684Hu ELISA Kit for Mucin 5 Subtype B (MUC5B) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA684Hu CLIA Kit for Mucin 5 Subtype B (MUC5B) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA684Mu01 Recombinant Mucin 5 Subtype B (MUC5B) Positive Control; Immunogen; SDS-PAGE; WB.
RPA684Mu02 Recombinant Mucin 5 Subtype B (MUC5B) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA684Mu01 Polyclonal Antibody to Mucin 5 Subtype B (MUC5B) WB; IHC; ICC; IP.
LAA684Mu71 Biotin-Linked Polyclonal Antibody to Mucin 5 Subtype B (MUC5B) WB; IHC; ICC.
LAA684Mu81 FITC-Linked Polyclonal Antibody to Mucin 5 Subtype B (MUC5B) Applications: WB; IHC; ICC; IP.
PAA684Mu02 Polyclonal Antibody to Mucin 5 Subtype B (MUC5B) WB; IHC; ICC; IP.
Assay Kits SEA684Mu ELISA Kit for Mucin 5 Subtype B (MUC5B) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA684Ra01 Recombinant Mucin 5 Subtype B (MUC5B) Positive Control; Immunogen; SDS-PAGE; WB.
RPA684Ra02 Recombinant Mucin 5 Subtype B (MUC5B) Positive Control; Immunogen; SDS-PAGE; WB.
RPA684Ra03 Recombinant Mucin 5 Subtype B (MUC5B) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA684Ra01 Polyclonal Antibody to Mucin 5 Subtype B (MUC5B) WB; IHC; ICC; IP.
PAA684Ra02 Polyclonal Antibody to Mucin 5 Subtype B (MUC5B) WB; IHC; ICC; IP.
PAA684Ra03 Polyclonal Antibody to Mucin 5 Subtype B (MUC5B) WB; IHC; ICC; IP.
Assay Kits SEA684Ra ELISA Kit for Mucin 5 Subtype B (MUC5B) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA684Bo01 Recombinant Mucin 5 Subtype B (MUC5B) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA684Bo01 Polyclonal Antibody to Mucin 5 Subtype B (MUC5B) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Mucin 5 Subtype B (MUC5B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mucin 5 Subtype B (MUC5B) ELISA Kit Customized Service Offer
  1. "Characterization of human mucin 5B gene expression in airway epithelium and the genomic clone of the amino-terminal and 5'-flanking region."Am. J. Respir. Cell Mol. Biol. 25:542-553(2001) [PubMed] [Europe PMC] [Abstract]
  2. "The amino-terminal sequence of MUC5B contains conserved multifunctional D domains: implications for tissue-specific mucin functions."Biochem. Biophys. Res. Commun. 251:350-355(1998) [PubMed] [Europe PMC] [Abstract]
  3. "Genomic organization of the human mucin gene MUC5B: cDNA and genomic sequences upstream of the large central exon."J. Biol. Chem. 273:30157-30164(1998) [PubMed] [Europe PMC] [Abstract]
  4. "Human mucin gene MUC5B, the 10.7 kb large central exon encodes various alternate subdomains resulting in a super-repeat. Structural evidence for a 11p15.5 gene family."J. Biol. Chem. 272:3168-3178(1997) [PubMed] [Europe PMC] [Abstract]
  5. "Proteolytic fragmentation and peptide mapping of human carboxyamidomethylated tracheobronchial mucin."J. Biol. Chem. 264:8193-8199(1989) [PubMed] [Europe PMC] [Abstract]
  6. "Identification of a major human high molecular weight salivary mucin (MG1) as tracheobronchial mucin MUC5B."Glycobiology 7:413-419(1997) [PubMed] [Europe PMC] [Abstract]
  7. "Molecular cloning of a major human gall bladder mucin: complete C-terminal sequence and genomic organization of MUC5B."Biochem. J. 324:295-303(1997) [PubMed] [Europe PMC] [Abstract]
  8. "Molecular cloning of a novel high molecular weight mucin (MG1) from human sublingual gland."Biochem. Biophys. Res. Commun. 217:1112-1119(1995) [PubMed] [Europe PMC] [Abstract]
  9. "Genomic organization of the 3 region of the human MUC5B mucin."J. Biol. Chem. 272:16873-16883(1997) [PubMed] [Europe PMC] [Abstract]
  10. "In vivo glycosylation of mucin tandem repeats."Glycobiology 11:459-471(2001) [PubMed] [Europe PMC] [Abstract]
  11. "C-Mannosylation of MUC5AC and MUC5B Cys subdomains."Glycobiology 14:325-337(2004) [PubMed] [Europe PMC] [Abstract]
  12. "Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry."J. Proteome Res. 5:1493-1503(2006) [PubMed] [Europe PMC] [Abstract]
  13. "A common MUC5B promoter polymorphism and pulmonary fibrosis." N. Engl. J. Med. 364:1503-1512(2011) [PubMed] [Europe PMC] [Abstract]
  14. "A variant in the promoter of MUC5B and idiopathic pulmonary fibrosis."N. Engl. J. Med. 364:1576-1577(2011) [PubMed] [Europe PMC] [Abstract]